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This report documents a novel lncRNA, GClnc1, which may act as a scaffold to recruit the WDR5 (Montrer WDR5 Kits ELISA) and KAT2A complex and modify the transcription of target genes. This study reveals that GClnc1 is an oncogenic lncRNA in human gastric cancer.
To understand how Gcn5 discriminates between different acyl-CoA molecules, structures of the catalytic domain of human Gcn5L2 bound to propionyl-CoA and butyryl-CoA were determined.
Data suggest that expression of GCN5 (histone acetyltransferase GCN5) is induced in skeletal muscle during a 48-hour fast; in contrast, expression of SIRT1 (sirtuin 1 (Montrer SIRT1 Kits ELISA)) remains unchanged.
Orc5 associates with the H3 histone acetyl transferase GCN5 (also known as KAT2A), and this association enhances the chromatin-opening function of Orc5.
Methionine was the only essential amino acid that rapidly induced PGC-1alpha acetylation through activating the GCN5 acetyltransferase.
these results may point to the GCN5-NF-kappaB (Montrer NFKB1 Kits ELISA) pathway as a novel potential molecular target for stem cell mediated regenerative medicine and the treatment of metabolic bone diseases such as osteoporosis.
Acetyltransferase p300 (Montrer EP300 Kits ELISA) collaborates with chromodomain helicase DNA-binding protein 4 (CHD4 (Montrer CHD4 Kits ELISA)) to facilitate DNA double-strand break repair
Suggest lysine acetyltransfer as a potential regulator of platelet actin dynamics, and potential roles for lysine acetylation in the molecular coordination of platelet activation and function.
Data uncover GCN5 as a negative regulator of C/EBPalpha (Montrer CEBPA Kits ELISA) and demonstrate the importance of C/EBPalpha (Montrer CEBPA Kits ELISA) acetylation in myeloid differentiation.
GCN5 Potentiates Glioma Proliferation and Invasion via STAT3 (Montrer STAT3 Kits ELISA) and AKT (Montrer AKT1 Kits ELISA) Signaling Pathways
recovering GCN5 expression in vivo by lentiviral expression vector significantly attenuated the loss of angiogenesis in ovariectomized mouse femurs
study reveals previously unknown physiological functions for Gcn5 and a molecular mechanism underlying these functions in regulating T cell immunity; Gcn5 may be an important new target for autoimmune disease therapy
Together, our experiments identify a novel nonhistone substrate of GCN5, highlight an essential role for both GCN5 and RA signaling in early diencephalic development, and elucidate a novel molecular regulatory mechanism for RA signaling that is specific to the developing forebrain.
In addition to reducing atrogene expression, surprisingly inhibiting NF-kappaB (Montrer NFKB1 Kits ELISA) with IkappaBalpha (Montrer NFKBIA Kits ELISA)-SR or by GCN5 knockdown in these muscles also enhanced AKT (Montrer AKT1 Kits ELISA) and mechanistic target of rapamycin (mTOR (Montrer FRAP1 Kits ELISA)) activities, which also contributed to the reduction in atrophy.
Gcn5 and PCAF (Montrer KAT2B Kits ELISA) repress IFN-beta (Montrer IFNB1 Kits ELISA) production in an enzymatic activity-independent and non-transcriptional manner: by inhibiting the innate immune signaling kinase TBK1 (Montrer TBK1 Kits ELISA) in the cytoplasm.
GCN5 and HDAC1 (Montrer HDAC1 Kits ELISA) are the crucial enzymes that regulating epigenetic reprogramming; we observed dynamic changes in the expression levels of GCN5 and HDAC1 (Montrer HDAC1 Kits ELISA) during embryo development
In conclusion, these data establish Kat2a as a novel and essential regulator of hippocampal memory consolidation.
Study reveals that Gcn5/PCAF (Montrer KAT2B Kits ELISA) facilitate adipogenesis through regulation of PPARgamma (Montrer PPARG Kits ELISA) expression and regulate brown adipogenesis by influencing Prdm16 (Montrer PRDM16 Kits ELISA) expression.
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009
histone acetyltransferase KAT2A
, general control of amino acid synthesis 5-like 2
, GCN5 general control of amino-acid synthesis 5-like 2
, general control of amino acid synthesis protein 5-like 2
, K(lysine) acetyltransferase 2A
, GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2
, General control of amino acid synthesis, yeast, homolog-like 2
, histone acetyltransferase GCN5
, lysine acetyltransferase 2A
, GCN5 general control of amino acid synthesis-like 2
, general control of amino acid synthesis, yeast homolog-like 2
, general control of amino acid synthesis-like 2