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Aperçu des produits pour anti-Aurora A (AURKA) Anticorps

Full name:
anti-Aurora Kinase A Anticorps (AURKA)
Chez www.anticorps-enligne.fr sont 287 Aurora Kinase A (AURKA) Anticorps de 28 de différents fournisseurs disponibles. De plus, nous expédions Aurora A Protéines (25) et Aurora A Kits (1) et beaucoup plus de produits pour cette protéine. Un total de 333 Aurora A produits sont actuellement listés.
Synonymes:
87A7-9/2, AIK, AIRK1, ARK-1, Ark1, AU019385, aur-a, AURA, aurka, aurka-a, Aurora-A, AURORA2, AW539821, Ayk1, BTAK, CG3068, ck10, ck[10], Dmel\\CG3068, Eg2, IAK, IAK1, l(3)87Ac, l(3)ck10, pEg2, PPP1R47, Stk6, STK7, STK15, wu:fb37c10, wu:fc02c02, zgc:100912
afficher tous les anticorps Gène GeneID UniProt
AURKA 6790 O14965
AURKA 20878 P97477
AURKA 261730  

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anti-Human Aurora A Anticorps:

anti-Mouse (Murine) Aurora A Anticorps:

anti-Rat (Rattus) Aurora A Anticorps:

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anti-Aurora A Anticorps mieux référencés

  1. Human Monoclonal Aurora A Primary Antibody pour IF, WB - ABIN393835 : Molli, Li, Bagheri-Yarmand, Pakala, Katayama, Sen, Iyer, Chernoff, Tsai, Nair, Kumar: Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. dans The Journal of cell biology 2010 (PubMed)
    Show all 5 references for ABIN393835

  2. Human Polyclonal Aurora A Primary Antibody pour ICC, IF - ABIN151735 : Hontz, Li, Lingle, Negron, Bruzek, Salisbury, Li: Aurora a and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: implications for chromosomal instability, aneuploidy, and neoplasia. dans Cancer research 2007 (PubMed)
    Show all 5 references for ABIN151735

  3. Cow (Bovine) Monoclonal Aurora A Primary Antibody pour ICC, IF - ABIN151177 : Cremet, Descamps, Vérite, Martin, Prigent: Preparation and characterization of a human aurora-A kinase monoclonal antibody. dans Molecular and cellular biochemistry 2003 (PubMed)
    Show all 2 references for ABIN151177

  4. Human Polyclonal Aurora A Primary Antibody pour ELISA, WB - ABIN184572 : Zhou, Kuang, Zhong, Kuo, Gray, Sahin, Brinkley, Sen: Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. dans Nature genetics 1998 (PubMed)

  5. Human Polyclonal Aurora A Primary Antibody pour IHC (p), WB - ABIN392389 : Kimura, Kotani, Hattori, Sumi, Yoshioka, Todokoro, Okano: Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1. dans The Journal of biological chemistry 1997 (PubMed)

  6. Cow (Bovine) Polyclonal Aurora A Primary Antibody pour IHC, WB - ABIN2777171 : Ye, Yang, Grossman, Dinney, Wu, Gu: Genetic variants in cell cycle control pathway confer susceptibility to bladder cancer. dans Cancer 2008 (PubMed)

Plus d’anticorps contre Aurora A partenaires d’interaction

Fruit Fly (Drosophila melanogaster) Aurora Kinase A (AURKA) interaction partners

  1. Disrupting the spindle assembly checkpoint in the aurA mutant does not prevent neuroblast amplification, tumor formation or chromosome segregation.

  2. Aurora A kinase activity contributes to phosphorylation of kinetochore substrates near poles and its inhibition results in chromosome misalignment and an increased incidence of erroneous kinetochore-MT attachments.

  3. AurA and aPKC exert the spatiotemporal control of Lgl distribution to achieve unique cell polarity roles in distinct cell types.

  4. Aurora A and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.

  5. Drosophila melanogaster aurora A phosphorylates the dynactin (Montrer DCTN1 Anticorps) subunit p150(glued (Montrer DCTN1 Anticorps)) on sites required for its association with the mitotic spindle.

  6. One of the functions of Aurora A kinase is to direct centrosomal organization such that D-TACC complexed to the MSPS/XMAP215 (Montrer CKAP5 Anticorps) microtubule-associated protein (Montrer FAM82A2 Anticorps) may be recruited, and thus modulate the behavior of astral microtubules.

  7. Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis.

  8. Deletion mapping identifies a central domain of Aurora-A as essential for its centrosomal localization that is augmented by both the amino and the carboxyl terminal ends of the protein.

  9. Results suggest that Aurora-A regulates centrosome assembly by controlling centrosomin's (CNN) ability to target and/or anchor gamma-tubulin (Montrer TUBG1 Anticorps) to the centrosome and to organize microtubule-nucleating sites via interaction with CNN.

  10. Aurora-A is essential for many crucial events during mitosis and phosphorylation of a series of substrates by Aurora-A at different stages of mitosis may promote diverse critical events in mitosis to maintain chromosome integrity in cells

Zebrafish Aurora Kinase A (AURKA) interaction partners

  1. Zebrafish Aurora-A is critically required for embryonic proliferation during development.

Human Aurora Kinase A (AURKA) interaction partners

  1. This study concludes that the helical region of TPX2 (Montrer TPX2 Anticorps) folds upon binding Aurora-A, and that stabilization of this helix does not compromise Aurora-A activation.

  2. AURKA may induce EMT (Montrer ITK Anticorps) to promote metastasis via activation of the FAK (Montrer PTK2 Anticorps)/PI3K (Montrer PIK3CA Anticorps) pathway in LSCC.

  3. a resorcinol derivative, 5-methyl-4-(2-thiazolylazo) resorcinol (PTK66), a dual inhibitor of Aurora A and Aurora B (Montrer AURKB Anticorps) kinases. PTK66 is a surface binding non-ATP analogue inhibitor that shows a mixed pattern of inhibition against both of Aurora A and B kinases

  4. Aurora-A overexpression upregulates MMP-2 (Montrer MMP2 Anticorps) expression through activating AKT (Montrer AKT1 Anticorps)/NF-kappaB (Montrer NFKB1 Anticorps) signaling pathway in esophageal squamous cell carcinoma cells. The level of Aurora-A expression was also positively correlated with the invasion capability of the cells.

  5. several hits in 3-5 nm range of activity against Aurora A kinase with rather good selectivity and ADME properties were obtained.

  6. overexpression of PAK1 (Montrer PAK1 Anticorps), NEK6 (Montrer NEK6 Anticorps), AURKA, and AURKB (Montrer AURKB Anticorps) genes in patients with Colorectal adenomatous polyp and colorectal cancer in the Turkish population.

  7. The reported findings suggest AURKA as a new tool to predict the clinical behavior of HGSOC. Particularly, these results suggest that AURKA may have a role both as predictor of platinum-resistance and prognostic factor.

  8. Upregulation of STK15 is associated with esophageal squamous cell carcinomas.

  9. Single nucleotide polymorphism in STK15 gene is Associated with Breast Cancer.

  10. The aurora kinase A inhibited by MLN (Montrer MLN Anticorps) 8054 are both implicated in cell cycle progression and, thus, in cellular proliferation.Epigenetic regulators were targeted by SAHA inhibiting HDACs and by DZNep inhibiting the histone methyltransferase EZH2 (Montrer EZH2 Anticorps), which silences genes by trimethylating histone H3K27.Combinations of small molecular inhibitors act synergistically in rhabdoid tumor

Mouse (Murine) Aurora Kinase A (AURKA) interaction partners

  1. observations revealed that the alteration of PKB-GSK-3beta axis, Plk-1, and Aurora kinase-A expressions in HSPC compartment due to DNA damage response was associated with the proliferative impairment and apoptosis during aplastic anemia.

  2. Augmented expression of Aurora kinase-A and Polo-like kinase-1 (Montrer PLK1 Anticorps) at the lactogenic switch likely mediates the formation of binucleated cells.

  3. Aurora A inhibition causes delocalized clustering of Lck (Montrer LCK Anticorps) at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A is required for maintaining Lck (Montrer LCK Anticorps) active during T-cell activation.

  4. Ndel1 (Montrer NDEL1 Anticorps) acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly.

  5. The Aurora kinase A and c-Myc (Montrer MYC Anticorps) expression and histone H3 (Montrer HIST3H3 Anticorps) phosphorylation level were comparatively higher in the cranial tumor than the caudal (Montrer CAD Anticorps).

  6. aurora kinase A (AURKA) represents a new therapeutic target in primary myelofibrosis.

  7. A novel function was identified for Aurora-A in controlling the polarization of macrophages and inflammation.

  8. Wdr62 (Montrer WDR62 Anticorps) interacts with Aurora A to control mitotic progression, and loss of these interactions leads to mitotic delay and cell death of NPCs, which could be a potential cause of human microcephaly.

  9. Reduced levels of Aurora A protein immediately post-thaw may be associated with the impaired oocyte maturation manifested by the delayed progression through meiosis

  10. Aurka is required for hematopoiesis, but is dispensable for megakaryocyte endomitosis.

Cow (Bovine) Aurora Kinase A (AURKA) interaction partners

  1. Aurora A was the most abundant form in oocytes, both at mRNA and protein levels, in bovine oocytes during meiotic maturation.

Pig (Porcine) Aurora Kinase A (AURKA) interaction partners

  1. Aurora kinase A is unlikely to be involved in CPEB1 (Montrer CPEB1 Anticorps) activating phosphorylation and cyclin B1 (Montrer CCNB1 Anticorps) mRNA polyadenylation during meiotic maturation of porcine oocytes.

  2. Aurora-A may be a multifunctional kinase that plays pivotal regulatory roles in microtubule assembly during porcine oocyte meiotic maturation, fertilization and early embryonic mitosis

  3. Aurora A stimulates the protein synthesis and promotes the meiotic resumption.

Xenopus laevis Aurora Kinase A (AURKA) interaction partners

  1. These results suggest a novel relationship between AurA and protein phosphatases during progression throughout the early embryonic cell cycle and shed new light on potential defects caused by AurA overexpression.

  2. MCAK (Montrer KIF2C Anticorps) colocalized with NuMA (Montrer NUMA1 Anticorps) and XMAP215 (Montrer CKAP5 Anticorps) at the center of Ran asters where its activity is regulated by Aurora A-dependent phosphorylation of S196, which contributes to proper pole focusing

  3. Plx1 (Montrer PLK1 Anticorps) promotes activation of Aurora A, most likely through TPX2.

  4. Aurora-A kinase is required for astral microtubule polymerization and spindle microtubule flux during chromosome segregation.

  5. Data show that Aurora A is a key regulator of microtubule assembly during M phase and therefore of bipolar spindle formation.

  6. binding and elution properties of both the phosphopeptides and unphosphorylated peptides of His6-Aurora A

  7. Results suggest that phosphorylation of maskin (Montrer TACC3 Anticorps) by Aurora-A prevents meiosis II proteins from being produced during meiosis I.

  8. The N-terminal non-catalytic domain of Aurora-A can localize to the centrosome in Xenopus egg extracts, while GFP fusions of either the N-terminal or catalytic domains are targeted to the centrosome in Xenopus XL2 cells.

  9. Here we identify G205 in Xenopus Aurora A as a key determinant of both intrinsic activity and regulation by TPX2

  10. The catalytic domain alone of Aurora-A is sufficient to restore spindle bipolarity; additional N-terminal sequences function in mitotic timing.

Aurora A (AURKA) profil antigène

Antigen Summary

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with Aurora A (AURKA)

  • aurora (aur) anticorps
  • aurora kinase A (aurka) anticorps
  • hypothetical protein (Aurora-A) anticorps
  • aurora kinase A (AURKA) anticorps
  • aurora kinase A (Aurka) anticorps
  • 87A7-9/2 anticorps
  • AIK anticorps
  • AIRK1 anticorps
  • ARK-1 anticorps
  • Ark1 anticorps
  • AU019385 anticorps
  • aur-a anticorps
  • AURA anticorps
  • aurka anticorps
  • aurka-a anticorps
  • Aurora-A anticorps
  • AURORA2 anticorps
  • AW539821 anticorps
  • Ayk1 anticorps
  • BTAK anticorps
  • CG3068 anticorps
  • ck10 anticorps
  • ck[10] anticorps
  • Dmel\\CG3068 anticorps
  • Eg2 anticorps
  • IAK anticorps
  • IAK1 anticorps
  • l(3)87Ac anticorps
  • l(3)ck10 anticorps
  • pEg2 anticorps
  • PPP1R47 anticorps
  • Stk6 anticorps
  • STK7 anticorps
  • STK15 anticorps
  • wu:fb37c10 anticorps
  • wu:fc02c02 anticorps
  • zgc:100912 anticorps

Protein level used designations for anti-Aurora Kinase A (AURKA) Anticorps

A-type aurora kinase , AuroraA , CG3068-PA , aur-PA , aurora A , aurora A kinase , aurora kinase , aurora-A , early-A , fruhe2 , Aurora A , hypothetical protein , aurora kinase A , fb37c10 , fc02c02 , serine/threonine-protein kinase 6 , serine/threonine protein kinase 6 , aurora A kinase protein , serine/threonine-protein kinase 6-like , ARK-1 , Aurora-A kinase , IPL1-related kinase , aurora 2 , aurora-related kinase 1 , aurora/IPL1-like kinase , aurora/IPL1-related kinase 1 , breast tumor-amplified kinase , breast-tumor-amplified kinase , hARK1 , protein phosphatase 1, regulatory subunit 47 , serine/threonine kinase 6 , serine/threonine protein kinase 15 , serine/threonine-protein kinase 15 , serine/threonine-protein kinase aurora-A , aurora family kinase 1 , ipl1- and aurora-related kinase 1 , serine/threonine-protein kinase Ayk1 , ratAurA , Aurora-A , Serine/threonine-protein kinase 6 , aurora kinase A-A , p46Eg265 , pEg2 , serine/threonine-protein kinase 6-A , serine/threonine-protein kinase Eg2 , serine/threonine-protein kinase Eg2-A

GENE ID SPECIES
41446 Drosophila melanogaster
549324 Xenopus (Silurana) tropicalis
7200473 Phaeodactylum tricornutum CCAP 1055/1
428167 Gallus gallus
445246 Danio rerio
469980 Pan troglodytes
698190 Macaca mulatta
100216431 Ovis aries
100303586 Saccoglossus kowalevskii
100398107 Callithrix jacchus
100459866 Pongo abelii
100469600 Ailuropoda melanoleuca
6790 Homo sapiens
20878 Mus musculus
261730 Rattus norvegicus
504437 Bos taurus
485940 Canis lupus familiaris
574063 Sus scrofa
397925 Xenopus laevis
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