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anti-Human CDC25C Anticorps:
anti-Mouse (Murine) CDC25C Anticorps:
anti-Rat (Rattus) CDC25C Anticorps:
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Human Monoclonal CDC25C Primary Antibody pour BI, WB - ABIN967552
Peng, Graves, Thoma, Wu, Shaw, Piwnica-Worms: Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. dans Science (New York, N.Y.) 1997
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Human Polyclonal CDC25C Primary Antibody pour IF (p), IHC (p) - ABIN746993
Yin, Jiang, Peng, Cui, Zhou, He, Zuo, Ouyang, Fan, Fang: The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum. dans Oncotarget 2016
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Human Polyclonal CDC25C Primary Antibody pour IF (p), IHC (p) - ABIN1387108
Ghate, Chaudhuri, Sarkar, Sajem, Panja, Rout, Mandal: An antioxidant extract of tropical lichen, Parmotrema reticulatum, induces cell cycle arrest and apoptosis in breast carcinoma cell line MCF-7. dans PLoS ONE 2013
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Human Monoclonal CDC25C Primary Antibody pour IHC, ELISA - ABIN1724739
Busch, Barton, Morgenstern, Götz, Günther, Noll, Montenarh: The G2/M checkpoint phosphatase cdc25C is located within centrosomes. dans The international journal of biochemistry & cell biology 2007
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Human Polyclonal CDC25C Primary Antibody pour IHC - ABIN965834
Chen, Zhang, Bower, Lu, Leonard, Ding, Castranova, Piwnica-Worms, Shi: Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway. dans Proceedings of the National Academy of Sciences of the United States of America 2002
Mdm2 (Montrer MDM2 Anticorps) overexpression and Cdc25C downregulation delay cell cycle progression through the G2/M phase.
Xanthatin functions as a DNA-damaging agent in non-small cell lung carcinomas by activating Chk1 (Montrer CHEK1 Anticorps)-mediated DDR (Montrer DDR1 Anticorps) and lysosome-mediated degradation of Cdc25C.
Myelodysplastic syndrome -related P95 (Montrer NBN Anticorps) point mutants of SRSF2 (Montrer SRSF2 Anticorps) lead to alternative splicing of CDC25C in a manner that is not dependent on the DNA damage response.
The aim of this review is to shed light on the role of four different phosphatases (PTEN (Montrer PTEN Anticorps), PP2A (Montrer PPP2R4 Anticorps), CDC25 (Montrer RASGRF1 Anticorps) and DUSP1 (Montrer DUSP1 Anticorps)) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.
Data show that TRIB2 (Montrer TRIB2 Anticorps)-mediated degradation of CDC25C is associated with lysine-48-linked CDC25C polyubiquitination driven by the TRIB2 (Montrer TRIB2 Anticorps) kinase-like domain.
the biology of the activation/deactivation of CDC25 (Montrer RASGRF1 Anticorps) by kinases/phosphatases to maintain the level of CDK (Montrer CDK4 Anticorps)-cyclin (Montrer PCNA Anticorps) activities and thus the genomic stability
the knockdown of CDC25C can reduce both the radiotherapy sensitivity and the proliferation activity of EC9706 cells.
results identify CDC25C as a downstream target of the mutated tyrosine kinase (Montrer TXK Anticorps) FLT3 (Montrer FLT3 Anticorps)-ITD affecting cell-cycle regulation in a model of AML (Montrer RUNX1 Anticorps)
Suggest that the p53 (Montrer TP53 Anticorps)-p21 (Montrer CDKN1A Anticorps)-DREAM-CDE/CHR pathway regulates p53 (Montrer TP53 Anticorps)-dependent repression of Survivin (Montrer BIRC5 Anticorps), CDC25C, and PLK1 (Montrer PLK1 Anticorps) in HCT116 cells.
Data indicate that nine compounds were identified with Ki values for CDC25A, -B and -C ranging from 0.01 to 4.4 muM.
oxidative stress-induced (Montrer SQSTM1 Anticorps) DNA damage of mouse zygotes triggers the cell cycle checkpoint, which results in G2/M cell cycle arrest, and that phospho-Cdc25B (Montrer CDC25B Anticorps) (Ser323), phospho-Cdc25C (Ser216), and phospho-Cdc2 (Montrer CDK1 Anticorps) (Tyr15) participate in activating the G2/M checkpoint.
The role of Cdc25c and Cdc25b (Montrer CDC25B Anticorps) in activating G2/M cell cycle checkpoint in zygote.
an asymmetrical distribution pattern for Cdc25c transcripts in 2-cell embryos.
CDC25A (Montrer CDC25A Anticorps) and CDC25B (Montrer CDC25B Anticorps) but not CDC25C compensate for each other to maintain the proliferative capacity of intestinal epithelial stem and progenitor cells
A single cell cycle genes homology region controls transcription of the cdc25C gene and is able to cooperate with E2F (Montrer E2F1 Anticorps) or Sp1 (Montrer SP1 Anticorps)/3 sites
Cdc25A (Montrer CDC25A Anticorps), or possibly other phosphatases, is able to functionally compensate for the loss of Cdc25B (Montrer CDC25B Anticorps) and Cdc25C in mice
The present study was aimed to investigate the possibility that selenium (Se)-induced oxidative stress mediated alterations in Cdc25c and p21 (Montrer D4S234E Anticorps) may cause modulations in the CDC2 (Montrer CDK1 Anticorps)/Cyclin B1 (Montrer CCNB1 Anticorps) complex responsible for G2/M phase checkpoint in spermatogenesis.
In Lzts1 (Montrer LZTS1 Anticorps)(-/-) mouse embryo fibroblasts (MEFs), Cdc25C degradation was increased during M phase, resulting in decreased Cdk1 (Montrer CDK1 Anticorps) activity.
PP2A:B56delta as a key upstream regulator of Cdk1 (Montrer CDK1 Anticorps) activity upon exit from mitosis
Blocking mitotic entry by adding the catalytic subunit of protein kinase A results in increased wee1 Ser549 phosphorylation and maintenance of cdc25C.
These observations identify PP2A (Montrer PPP2R2B Anticorps)/B56delta as a central checkpoint effector and suggest a mechanism for controlling 14-3-3 (Montrer YWHAQ Anticorps) interactions to promote mitosis.
In Xenopus oocytes, p42 MAPK (Montrer MAPK1 Anticorps) interacts with hypophosphorylated Cdc25 before meiotic induction. During meiotic induction, p42 MAPK (Montrer MAPK1 Anticorps) phosphorylates Cdc25 at three sites, increasing Cdc25's phosphatase activity.
This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.
cell division cycle 25 homolog C (S. pombe)
, m-phase inducer phosphatase 3-like
, cell division cycle 25 homolog C
, cell division cycle 25C
, Dual specificity phosphatase Cdc25C
, M-phase inducer phosphatase 3
, dual specificity phosphatase Cdc25C
, dual specificity phosphatase CDC25C
, mitosis inducer CDC25
, phosphotyrosine phosphatase
, protein phosphatase 1, regulatory subunit 60
, cell cycle phosphatase CDC25C
, cell division cycle control protein 25C