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CDK8-CycC may serve as transcriptional cofactors for EcR-dependent transcription.
observed biochemical association between Integrator proteins and cyclin C/Cdk8 (Montrer CDK8 Protéines), and that overexpression of a kinase-dead Cdk8 (Montrer CDK8 Protéines) causes snRNA misprocessing
our results suggest that mTORC1 activation in NAFLD and insulin (Montrer INS Protéines) resistance results in down-regulation of the CDK8 (Montrer CDK8 Protéines)-CycC complex and elevation of lipogenic protein expression.
results suggest that CCNC temporarily protects SRC-2 (Montrer NCOA2 Protéines) against degradation and this event is involved in the transcriptional regulation of SRC-2 (Montrer NCOA2 Protéines) cell cycle target genes.
Cancer-mediated CDK8 (Montrer CDK8 Protéines) point mutations (D173A and D189N) change the binding pattern of cdk8 (Montrer CDK8 Protéines) to its partner, CycC.
cyclin-C-CDK (Montrer CDK4 Protéines) complexes phosphorylate the Notch1 (Montrer NOTCH1 Protéines) intracellular domain (ICN1) and promote ICN1 degradation
analysis of the structure-kinetic relationship of the cyclin-dependent kinase 8 (CDK8 (Montrer CDK8 Protéines))/cyclin C (CycC) complex
Silencing beta-catenin gene may induce changes of cell cycle and in cyclin B1 and cyclin C protein expression.
2.2-A crystal structure of CDK8 (Montrer CDK8 Protéines)/CycC in complex with sorafenib; CDK8 (Montrer CDK8 Protéines) structure reveals a unique CycC recognition helix that explains the specificity of the CDK8 (Montrer CDK8 Protéines)/CycC pair and discrimination among the highly promiscuous binding in the CDK (Montrer CDK4 Protéines)/cyclin (Montrer PCNA Protéines) family
Studies establish cyclin C as a critical regulator of the G(0)/G(1) transition of human HSPCs and suggest that modulating cyclin C levels may be useful for HSC (Montrer FUT1 Protéines) expansion and more efficient engraftment.
The present observations suggest different cellular functions of cyclin C in neurons and astrocytes in alzheimer's disease.
A cellular pool of cyclin C combines with cdk3 (Montrer CDK3 Protéines) to stimulate pRb (Montrer RB1 Protéines) phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently.
these data indicate that CycC activates adipogenesis in part by stimulating the transcriptional activity of C/EBPalpha (Montrer CEBPA Protéines).
cyclin C connects stress-induced mitochondrial hyperfission and programmed cell death in mammalian cells.
Data show that the isolated 3.6-KB promoter fragment alone is not sufficient for the complete physiological modulation of cyclin C RNA.
Results identify LSF (Montrer TFCP2 Protéines) as only the second known target (in addition to pRb (Montrer PGR Protéines)) of cyclin C/CDK2 (Montrer CDK2 Protéines) activity during progression from quiescence to early G(1).
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.
, SRB11 homolog
, dJ199J3.4 (cyclin C)