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This study describes the identification and characterization of cyclin D3 as a novel interactor of influenza A virus M2 protein.
MicroRNA-138 interacts with cyclin D3 and negatively regulates non-small cell lung cancer cells
Combined urinary FGFR3 (Montrer FGFR3 Kits ELISA)/Cyclin D3 expression shows improved detection rates for bladder cancer recurrence with high specificity and sensitivity.
cyclin-D1 (Montrer CCND1 Kits ELISA) and cyclin-D3 within human islet cells varies according to the status of the pancreas donor
The CDK6 (Montrer CDK6 Kits ELISA)-cyclin D3 pair play a fundamental role in controlling CDK2 (Montrer CDK2 Kits ELISA)-dependent SAMHD1 (Montrer SAMHD1 Kits ELISA) phosphorylation and the dNTP pool in primary macrophages.
Two recurrent fusion genes associated with the 12q locus, LRP1 (Montrer LRP1 Kits ELISA)-SNRNP25 (Montrer SNRNP25 Kits ELISA) and KCNMB4 (Montrer KCNMB4 Kits ELISA)-CCND3, were by RT-PCR, Sanger sequencing and FISH, and were found to be osteosarcoma specific in a validation cohort of 240 other sarcomas.
G1 arrest induced by SB265610 occurred at concentrations lacking CXCR2 (Montrer CXCR2 Kits ELISA) selectivity and revealed cyclin-dependent kinase 2 (CDK2 (Montrer CDK2 Kits ELISA)) (Thr160) hypophosphorylation, cyclin D3 gene down-regulation, and p21 (Montrer CDKN1A Kits ELISA) post-translational induction
sLZIP regulates the transcription of cyclin D3 by binding directly to the AP-1 (Montrer FOSB Kits ELISA) region in the cyclin D3 promoter.
combined expression of miR (Montrer MLXIP Kits ELISA)-138 and its direct target CCND3 may be correlated with significant characteristics of hepatocellular carcinoma
Namely the amplification of the expression of the PLCB1a (Montrer PLCB1 Kits ELISA), but not of PLCB1b (Montrer PLCB1 Kits ELISA), is able to maintain high levels of expression of cyclin D3 even after treatment with kinamycin F
The swine UCHL3 (Montrer Uchl3 Kits ELISA), RIT1 (Montrer RIT1 Kits ELISA) and CCND3 genes were found to be differentially expressed in tissues including small intestine, large intestine, liver, muscle, fat, lung, spleen and kidney.
immature B and T cells use lymphocyte lineage- and developmental stage-specific mechanisms to inhibit Cyclin D3 protein levels.
we suggest that proper regional decidualization and polyploidy development requires FoxM1 (Montrer FOXM1 Kits ELISA) signaling downstream of Hoxa10 (Montrer HOXA10 Kits ELISA) and cyclin D3.
Cyclin D3 protein that drives immature T cell proliferation is essential for transformation of Atm (Montrer ATM Kits ELISA)-deficient thymocytes
DYRK1A (Montrer DYRK1A Kits ELISA) has a role in lymphopoiesis; Cyclin D3 protein stability is negatively regulated during exit from the proliferative phases of B and T cell development
inactivation of Ccnd3 leads to increased frequencies of lymphocytes with biallelic expression of IgH or TCRbeta genes.
FGF2 signaling results in the phosphorylation of Erk1/2, and activation of c-Fos and c-Jun that lead to elevated cyclin D mRNA levels.
Results indicate that cyclin D3 plays a cell-autonomous and nonredundant function in regulating the dynamic balance between proliferation, differentiation, and self-renewal that normally establishes an appropriate pool size of adult satellite cells.
Investigated the expression of GABA and GABPR in the early-pregnancy mouse uterus. Cyclin D3 was measured in cultured stromal cells artificially induced to undergo decidualization, by GABA and a GABA A-type receptor agonist or antagonist.
Subnuclear compartmentalization enables cyclin D3 to drive cell cycle progression and repress V gene accessibility, thereby ensuring coordination of proliferation with immunoglobulin recombination.
cyclin D3 expression influences a host of genes involved in decidualization and can improve decidualization in Hoxa-10 (Montrer HOXA10 Kits ELISA)(-/-) mice.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.
, G1/S-specific cyclin-D3
, D3-type cyclin
, G1/S-specific cyclin D3