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anti-Human FOXO3 Anticorps:
anti-Rat (Rattus) FOXO3 Anticorps:
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Human FOXO3 Primary Antibody pour IHC - ABIN966150
Smith, Norton, Gorospe, Jiang, Nemoto, Holbrook, Finkel, Kusiak: Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. dans The Journal of cell biology 2005
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Human Polyclonal FOXO3 Primary Antibody pour IHC - ABIN966151
Essafi, Fernández de Mattos, Hassen, Soeiro, Mufti, Thomas, Medema, Lam: Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. dans Oncogene 2005
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Human Polyclonal FOXO3 Primary Antibody pour ChIP, ICC - ABIN4312377
Sinanoglu, Yener, Ekici, Midi, Aksungar: The protective effects of spirulina in cyclophosphamide induced nephrotoxicity and urotoxicity in rats. dans Urology 2012
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Human Polyclonal FOXO3 Primary Antibody pour IF, IHC - ABIN1355835
Lehtinen, Yuan, Boag, Yang, Villén, Becker, DiBacco, de la Iglesia, Gygi, Blackwell, Bonni: A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. dans Cell 2006
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Human Polyclonal FOXO3 Primary Antibody pour ICC, IF - ABIN152044
Yuan, Luo, Liu, Lou: Regulation of SIRT1 activity by genotoxic stress. dans Genes & development 2012
Dog (Canine) Polyclonal FOXO3 Primary Antibody pour ELISA, WB - ABIN2473689
Dijkers, Birkenkamp, Lam, Thomas, Lammers, Koenderman, Coffer: FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. dans The Journal of cell biology 2002
Human Polyclonal FOXO3 Primary Antibody pour IF (p), IHC (p) - ABIN731168
Morales, Abrigo, Acuña, Santos, Bader, Brandan, Simon, Olguin, Cabrera, Cabello-Verrugio: Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas. dans Disease models & mechanisms 2016
Human Polyclonal FOXO3 Primary Antibody pour ELISA, WB - ABIN250244
Brunet, Bonni, Zigmond, Lin, Juo, Hu, Anderson, Arden, Blenis, Greenberg: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. dans Cell 1999
Human Polyclonal FOXO3 Primary Antibody pour ICC, IF - ABIN152045
Lin, Jan, Kuo: Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine. dans Molecular pharmaceutics 2015
by modulating hypoxia-inducible factor activity via up-regulation of VHL (Montrer VHL Anticorps), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
NOTCH1 (Montrer NOTCH1 Anticorps) inhibits activation of ATM (Montrer ATM Anticorps) by impairing the formation of an ATM (Montrer ATM Anticorps)-FOXO3a-KAT5 (Montrer KAT5 Anticorps) complex.
FOXO3 is required to induce autophagy and thereby reduce elevated reactive oxygen species levels.
A total of 41 differentially expressed genes, such as SOCS3 (Montrer SOCS3 Anticorps), VAPA (Montrer VAPA Anticorps), and COL5A2 (Montrer COL5A2 Anticorps), are speculated to have roles in the pathogenesis of acute myocardial infarction; 2 transcription factors FOXO3 and MYBL2 (Montrer MYBL2 Anticorps), and 2 miRNAs hsa (Montrer CD24 Anticorps)-miR (Montrer MLXIP Anticorps)-21-5p and hsa (Montrer CD24 Anticorps)-miR (Montrer MLXIP Anticorps)-30c-5p may be involved in the regulation of the expression of these differentially expressed genes.
Downregulation of PKC (Montrer PRRT2 Anticorps) induces senescence through the AKT (Montrer AKT1 Anticorps)-FoxO3a-ROS (Montrer ROS1 Anticorps)-p53 (Montrer TP53 Anticorps)-p21(Cip1/WAF1 (Montrer CDKN1A Anticorps)) pathway in HCT116 and HEK293 cells.
we demonstrated that REP1 blocked the nuclear trans-localization of FOXO3 through physically interacting with FOXO3, thereby suppressing FOXO3-mediated apoptosis. Importantly, the inhibition of REP1 combined with 5-FU treatment could lead to significant retarded tumor growth in a xenograft tumor model of human cancer cells
TLR4 (Montrer TLR4 Anticorps) and C5aR (Montrer C5AR1 Anticorps) crosstalk in dendritic cells induces a core regulatory network of RSK2 (Montrer RPS6KA3 Anticorps), PI3Kbeta, SGK1 (Montrer SGK1 Anticorps), and FOXO transcription factors.
FoxO3a is an early stress response protein to glucose toxicity in diabetic conditions.
In cigarette smoke extract stimulated bronchial epithelial cells, carbocysteine increased cell proliferation, and SIRT1 (Montrer SIRT1 Anticorps) and FoxO3 nuclear expression, and reduced beta galactosidase (Montrer GLB1 Anticorps) and survivin (Montrer BIRC5 Anticorps) expression.
geminin (Montrer GMNN Anticorps) selectively couples the transcription factor forkhead box O3 (FoxO3) to HDAC3 (Montrer HDAC3 Anticorps), thereby specifically facilitating FoxO3 deacetylation.
Data suggest that forkhead box O3A protein (FoxO3a) might be a prognostic biomarker or a potential therapeutic target in glioblastoma.
MiR (Montrer MLXIP Anticorps)-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a.
Our results show for the first time that DC FOXO3 expression and function is altered in females. In vitro results indicate that these differences may be the result of exposure to estrogen. These differences may be critical considerations for the enhancement of immunotherapy for cancer.
Data, including data from studies using transgenic/knockout mice, suggest that FoxO3 activation via post-translational phosphorylation can both induce and maintain autophagic activities in renal tubule epithelium in response to injury from unilateral ureteral obstruction; under these conditions, nuclear expression of FoxO3 is up-regulated in hypoxic proximal tubules exhibiting high levels of autophagy.
The Foxo3-Eomes (Montrer EOMES Anticorps) pathway is central to achieve the complete specialized gene program required for pathogenic Th1 (Montrer HAND1 Anticorps) cell differentiation.
these results show that Cdk5 (Montrer CDK5 Anticorps)-mediated phospho-regulation of Foxo3 can activate several genes that promote neuronal death and aberrant Abeta (Montrer APP Anticorps) processing, thereby contributing to the progression of neurodegenerative pathologies.
the transcription factor Forkhead box O3 (FoxO3) was found to be an essential regulator of the maintenance of pluripotency in dormant embryonic stem cells.
Loss of Foxo3 function resulted in more severe arthritis in vivo (both clinically and histologically) and was associated with higher titers of anticollagen antibodies and interleukin-6 (Montrer IL6 Anticorps) in the blood.
results indicate that DNA damage accrued as a result of elevated ROS in Foxo3(-/-) mutant HSPC is at least partially reversible
Foxo1 (Montrer FOXO1 Anticorps), Foxo3a, and Foxo4 (Montrer FOXO4 Anticorps) in chondrocytes regulate endochondral bone formation.
Data show that resveratrol reduced mitochondrial reactive oxygen species (mROS) generation by promoting Sirt3 (Montrer SIRT3 Anticorps) enrichment within the mitochondria and subsequent upregulation of FoxO3a-mediated mitochondria gene expression of PGC-1alpha (Montrer PPARGC1A Anticorps) and SOD2 (Montrer SOD2 Anticorps).
These results indicate that myostatin (Montrer MSTN Anticorps) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (Montrer NR3C1 Anticorps) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN (Montrer PTEN Anticorps), FOXO3A and PKB (Montrer AKT1 Anticorps) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
NO/protein kinase (Montrer CDK7 Anticorps) G (PKG (Montrer PRKG1 Anticorps))-dependent downregulation of PGC-1 alpha (Montrer PPARGC1A Anticorps) and the ROS (Montrer ROS1 Anticorps) detoxification system in endothelial cells are mediated by the PI3K/Akt (Montrer AKT1 Anticorps) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (Montrer ROS1 Anticorps)-induced apoptosis in mammalian cells.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like