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anti-Human HIPK2 Anticorps:
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Cow (Bovine) Polyclonal HIPK2 Primary Antibody pour IHC, WB - ABIN2779735
Steinmann, Schulte, Beck, Chachra, Bujnicki, Klempnauer: v-Myc inhibits C/EBPbeta activity by preventing C/EBPbeta-induced phosphorylation of the co-activator p300. dans Oncogene 2009
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Human Polyclonal HIPK2 Primary Antibody pour EIA - ABIN358542
Guha, Chaerkady, Marimuthu, Patterson, Kashyap, Harsha, Sato, Bader, Lash, Minna, Pandey, Varmus: Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS. dans Proceedings of the National Academy of Sciences of the United States of America 2008
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Human Monoclonal HIPK2 Primary Antibody pour ELISA, WB - ABIN565400
Esposito, Tornincasa, Chieffi, De Martino, Pierantoni, Fusco: High-mobility group A1 proteins regulate p53-mediated transcription of Bcl-2 gene. dans Cancer research 2010
Human Monoclonal HIPK2 Primary Antibody pour ICC, IF - ABIN2668288
Isono, Nemoto, Li, Takada, Suzuki, Katsuki, Nakagawara, Koseki: Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. dans Molecular and cellular biology 2006
Hipk2 promotes PP1c-mediated Dvl (Montrer DVL2 Anticorps) dephosphorylation via its C-terminal domain and is essential Dvl (Montrer DVL2 Anticorps) stability.
Cytoplasmic relocalization of HIPK2 induced by HMGA1 (Montrer HMGA1 Anticorps) overexpression is a mechanism of inactivation of p53 (Montrer TP53 Anticorps) apoptotic function.
Furthermore, our results suggest that modulation of either HIPK2 levels or activity could be exploited to impair NRF2 (Montrer GABPA Anticorps)-mediated signalling in cancer cells, and thus sensitise them to chemotherapeutic drugs.
PARP1 (Montrer PARP1 Anticorps) can modulate the tumor-suppressing function of HIPK2 by regulating the protein stability of HIPK2.
Data show that HIPK2-T566 phosphorylation contributes to UV-induced HIPK2 activity but it is dispensable for doxorubicin response.
In this study, we report that the kinase HIPK2 is responsible for facilitating the Fbw7 (Montrer FBXW7 Anticorps)-dependent proteasomal degradation of Notch1 (Montrer NOTCH1 Anticorps) by phosphorylating its intracellular domain (Notch1 (Montrer NOTCH1 Anticorps)-IC) within the Cdc4 (Montrer FBXW7 Anticorps) phosphodegron motif.
the migration and invasion of hepatocellular carcinoma cells were impaired by knockdown of histone deacetylase 5 (Montrer HDAC5 Anticorps) or hypoxia-inducible factor-1alpha but rescued when eliminating homeodomain-interacting protein kinase-2 in hepatocellular carcinoma cells, which suggested the critical role of histone deacetylase 5 (Montrer HDAC5 Anticorps)-homeodomain-interacting protein kinase-2-hypoxia-inducible factor-1alpha pathway in hypoxia-induced metastasis.
These results suggest that the HIPK2-phospho-Ser271 CREB (Montrer CREB1 Anticorps) axis is a new arsenic-responsive CREB (Montrer CREB1 Anticorps) activation mechanism in parallel with the PKA-phospho-Ser133 CREB (Montrer CREB1 Anticorps) axis.
Results demonstrated that HIPK2 may function as a novel regulator to modulate hepatic stellate cells activation, potentially by inhibiting the TGF-beta1 (Montrer TGFB1 Anticorps)/Smad3 (Montrer SMAD3 Anticorps) signaling pathway.
Data show strong reduction of cell viability was induced in vitro and in vivo by the homeodomain interacting protein kinase 2 exon 8 spliced isoform (Hipk2-Deltae8)-specific siRNA, supporting a potential therapeutic application.
Results indicate that Hipk2 exerts a relevant role in the survival of cerebellar Purkinje cells and that Hipk2 genetic ablation generates cerebellar dysfunction compatible with an ataxic-like phenotype.
reveal a previously unrecognized role of HIPK2 activation in ER-stress-mediated neurodegeneration and its potential role as a biomarker and therapeutic target for amyotrophic lateral sclerosis
HIPK2 is ubiquitinated upon heat shock.
Phosphorylation of KLF3 (Montrer KLF3 Anticorps) and CtBP2 (Montrer CTBP2 Anticorps) by HIPK2 strengthens the interaction between these two factors and increases transcriptional repression by KLF3 (Montrer KLF3 Anticorps).
Homeodomain-interacting protein kinase 2, a novel autoimmune regulator (Montrer AIRE Anticorps) interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.
Hipk2 has an essential role in mouse white fat development
data identify Hipk2 as a novel regulator of C/EBPbeta (Montrer CEBPB Anticorps) and implicate different protein kinases in the cooperation of p300 (Montrer NOTCH1 Anticorps) with C/EBPbeta (Montrer CEBPB Anticorps) and C/EBPalpha (Montrer CEBPA Anticorps)
Data indicate a critical kinase HIPK2 function in cytokinesis and in the prevention of tetraploidization.
Hipk2 is a haploinsufficient tumor suppressor gene for mouse lymphoma development.
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene.
homeodomain interacting protein kinase 2
, serine/threonine protein kinase
, homeodomain-interacting protein kinase 2-like
, homeodomain-interacting protein kinase 2
, homeodomain-interacting protein kinase-2
, nuclear body-associated kinase 1
, sialophorin tail-associated nuclear serine/threonine-protein kinase
, Mx-interacting protein kinase PKM