Aperçu des produits pour anti-SMAD2 (SMAD2) Anticorps

Full name:
anti-SMAD, Mothers Against DPP Homolog 2 Anticorps (SMAD2)
Chez www.anticorps-enligne.fr sont 424 SMAD, Mothers Against DPP Homolog 2 (SMAD2) Anticorps de 30 de différents fournisseurs disponibles. De plus, nous expédions SMAD2 Kits (43) et SMAD2 Protéines (29) et beaucoup plus de produits pour cette protéine. Un total de 516 SMAD2 produits sont actuellement listés.
Synonymes:
7120426M23Rik, fj43c06, hMAD-2, hSMAD2, JV18, JV18-1, Madh2, Madr2, mMad2, Smad-2, wu:fj43c06, Xmad2, XSmad2

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anti-SMAD2 Anticorps mieux référencés

  1. Human Polyclonal SMAD2 Primary Antibody pour IF, IHC - ABIN1532651 : Zhang, Feng, We, Derynck: Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. dans Nature 1996 (PubMed)
    Show all 2 references for 1532651

  2. Human Polyclonal SMAD2 Primary Antibody pour ELISA, WB - ABIN1532650 : Eppert, Scherer, Ozcelik, Pirone, Hoodless, Kim, Tsui, Bapat, Gallinger, Andrulis, Thomsen, Wrana, Attisano: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. dans Cell 1996 (PubMed)
    Show all 2 references for 1532650

  3. Human Polyclonal SMAD2 Primary Antibody pour IHC (p), IHC - ABIN316295 : Lee, Lee, Bae, Jung: Abnormal liver differentiation and excessive angiogenesis in mice lacking Runx3. dans Histochemistry and cell biology 2013 (PubMed)

  4. Cow (Bovine) Polyclonal SMAD2 Primary Antibody pour WB - ABIN2780721 : Zheng, Zugates, Lu, Shi, Bai, Lee: Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons. dans The EMBO journal 2006 (PubMed)

  5. Human Polyclonal SMAD2 Primary Antibody pour IF, WB - ABIN391546 : Funaba, Zimmerman, Mathews: Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase. dans The Journal of biological chemistry 2002 (PubMed)

  6. Cow (Bovine) Polyclonal SMAD2 Primary Antibody pour IHC, WB - ABIN2779412 : Antonson, Jakobsson, Almlöf, Guldevall, Steffensen, Gustafsson: RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3. dans The Journal of biological chemistry 2008 (PubMed)

Plus d’anticorps contre SMAD2 partenaires d’interaction

Zebrafish SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. The results of this study found that Bptf (Montrer BPTF Anticorps) and TGF-beta (Montrer TGFB1 Anticorps)/Smad2 mediate nucleosome remodeling to regulate wnt8a (Montrer WNT8A Anticorps) expression and hence neural posteriorization.

  2. Smad2 and Eomesodermin (Montrer EOMES Anticorps) a (Eomesa (Montrer EOMES Anticorps)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (Montrer EOMES Anticorps) forms a general component of the Smad2 signalling complex in zebrafish.

  3. These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.

  4. study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription

  5. Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.

  6. Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Human SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. selective inhibition of SMAD3 (Montrer SMAD3 Anticorps) or CCT6A (Montrer CCT6A Anticorps) efficiently suppresses TGF-beta (Montrer TGFB1 Anticorps)-mediated metastasis. Findings provide a mechanism that directs TGF-beta (Montrer TGFB1 Anticorps) signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta (Montrer TGFB1 Anticorps) for non-small-cell lung carcinoma.

  2. In response to TGF-beta (Montrer TGFB1 Anticorps), RASSF1A (Montrer RASSF1 Anticorps) is recruited to TGF-beta (Montrer TGFB1 Anticorps) receptor I and targeted for degradation by the co-recruited E3 ubiquitin ligase (Montrer MUL1 Anticorps) ITCH. RASSF1A (Montrer RASSF1 Anticorps) degradation is necessary to permit Hippo pathway effector YAP1 (Montrer YAP1 Anticorps) association with SMADs and subsequent nuclear translocation of receptor-activated SMAD2.

  3. Smad2 is a key scaffold, allowing RIN1 (Montrer RIN1 Anticorps) to act as a GTP (Montrer AK3 Anticorps) exchange factor for MFN2 (Montrer MFN2 Anticorps)-GTPase (Montrer RACGAP1 Anticorps) activation to promote mitochondrial ATP synthesis and suppress superoxide production during mitochondrial fusion.

  4. Ang (Montrer ANG Anticorps) down-regulate the expression of Col (Montrer HDAC1 Anticorps)-I, alpha-SMA (Montrer SMN1 Anticorps) and TGF-beta1 (Montrer TGFB1 Anticorps)/Smad2/3 and subsequently inhibits fibroblast-myofibroblast transition.

  5. The nuclear importin (Montrer KPNA4 Anticorps) IPO5 (Montrer IPO5 Anticorps) was identified as a novel interacting protein of SMAD1 (Montrer GARS Anticorps). Overexpression of IPO5 (Montrer IPO5 Anticorps) in various cell lines specifically increases nuclear localization of BMP receptor (Montrer BMPR1A Anticorps)-activated SMADs (R-SMADs) confirming a functional relationship between IPO5 (Montrer IPO5 Anticorps) and BMP but not TGF-beta (Montrer TGFB1 Anticorps) R-SMADs.

  6. Our findings suggest a stronger chondrogenic potential of CD105(+) SMSCs in comparison to that of CD105(-) SMSCs and that CD105 enhances chondrogenesis of SMSCs by regulating TGF-beta (Montrer TGFB1 Anticorps)/Smad2 signaling pathway, but not Smad1 (Montrer GARS Anticorps)/5. Our study provides a better understanding of CD105 with respect to chondrogenic differentiation.

  7. the findings show that TIEG1 (Montrer KLF10 Anticorps) is highly expressed in human keloids and that it directly binds and represses Smad7 (Montrer SMAD7 Anticorps) promoter-mediated activation of TGF-beta (Montrer TGFB1 Anticorps)/Smad2 signaling

  8. A significant association was found between the low expression of inhibitory protein SMAD-7 (Montrer SMAD7 Anticorps) and both zeta-chain-associated protein kinase (Montrer CDK7 Anticorps) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (Montrer GARS Anticorps)/8 and lower SMAD-4 (Montrer SMAD4 Anticorps) expression in chronic lymphocytic leukemia cells

  9. High expression of SMAD2 is associated with colorectal carcinoma.

  10. this study shows that tolfenamic acid inhibits growth of colon cancer cells through downregulation of Smad2

Xenopus laevis SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. Grg4 (Montrer TLE4 Anticorps) occupancy at the Xnr1 (Montrer NODAL Anticorps) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 (Montrer TLE4 Anticorps) from FoxH1 (Montrer FOXH1 Anticorps) at the Xnr1 (Montrer NODAL Anticorps) enhancer, an essential feature of the transcriptional switch mechanism.

  2. E2a (Montrer TCF3 Anticorps) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

  3. GDF11 (Montrer GDF11 Anticorps) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.

  4. XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.

Pig (Porcine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. Activin A (Montrer INHBA Anticorps) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (Montrer NANOG Anticorps) and OCT4 (Montrer POU5F1 Anticorps),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (Montrer NANOG Anticorps)/OCT4 (Montrer POU5F1 Anticorps) expression.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (Montrer TGFB1 Anticorps) signalling that incorporates elements of previous models together with crosstalking between Smad1 (Montrer SMAD1 Anticorps)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (Montrer SMAD7 Anticorps).

Mouse (Murine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. selective inhibition of SMAD3 (Montrer SMAD3 Anticorps) or CCT6A (Montrer CCT6A Anticorps) efficiently suppresses TGF-beta (Montrer TGFB1 Anticorps)-mediated metastasis. Findings provide a mechanism that directs TGF-beta (Montrer TGFB1 Anticorps) signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta (Montrer TGFB1 Anticorps) for non-small-cell lung carcinoma.

  2. results demonstrate that TGF-beta1 (Montrer TGFB1 Anticorps)-induced autophagy links beta-catenin (Montrer CTNNB1 Anticorps) and Smad (Montrer SMAD1 Anticorps) signaling to promote epithelial-mesenchymal transition in C1.1 cells through a novel pY654-beta-catenin (Montrer CTNNB1 Anticorps)/p-Smad2/ILK (Montrer ILK Anticorps) pathway.

  3. These results suggest that Nedd9 (Montrer NEDD9 Anticorps) is a Smad2/3 target gene implicated in RANKL (Montrer TNFSF11 Anticorps)-induced osteoclastogenesis.

  4. In conclusion, TGF-beta (Montrer TGFB1 Anticorps) signaling pathway may influence liver fibrosis by incorporating with YB-1 (Montrer YBX1 Anticorps), indicating that YB-1 (Montrer YBX1 Anticorps) could be a potential target for therapies against liver fibrosis.

  5. miR (Montrer MLXIP Anticorps)-27b is an anti-fibrotic microRNA that inhibits fibroblast activation by targeting TGFbeta (Montrer TGFB1 Anticorps) receptor 1 and SMAD2.

  6. hese studies revealed that Smad2 plays an essential role in the development of the growth plate, that both Smads 2 and 3 inhibit Ihh (Montrer IHH Anticorps) expression in the neonatal growth plate, and suggested they accomplish this by binding to distinct SBEs, mediating assembly of distinct repressive complexes.

  7. This study found evidence of increased leukocyte phosphorylated-Smad2/3 staining in both single leukocytes and platelet-leukocyte aggregates in mice that developed aortic valve stenosis, suggesting the presence of increased circulating active TGF-beta1 (Montrer TGFB1 Anticorps).

  8. Data show that muscle-specific (Montrer EIF3K Anticorps) Smad (Montrer SMAD1 Anticorps) proteins Smad2/3-deficient mice exhibited significant resistance to denervation-induced muscle atrophy.

  9. these data demonstrate that the SMI drives ES cells to skeletal muscle via concerted activation of the Wnt (Montrer WNT2 Anticorps) pathway, and inhibition of Smad2/3 signaling and Shh (Montrer SHH Anticorps) pathways.

  10. Arsenite disrupts zinc-dependent TGFbeta2-SMAD2/3 activity during murine cardiac progenitor cell differentiation.

SMAD2 profil antigène

Antigen Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with SMAD2

  • SMAD family member 2 (SMAD2) anticorps
  • SMAD family member 2 (smad2) anticorps
  • MAD homolog 2 (Drosophila) (smad2) anticorps
  • SMAD family member 2 (Smad2) anticorps
  • 7120426M23Rik anticorps
  • fj43c06 anticorps
  • hMAD-2 anticorps
  • hSMAD2 anticorps
  • JV18 anticorps
  • JV18-1 anticorps
  • Madh2 anticorps
  • Madr2 anticorps
  • mMad2 anticorps
  • Smad-2 anticorps
  • wu:fj43c06 anticorps
  • Xmad2 anticorps
  • XSmad2 anticorps

Protein level used designations for SMAD2

SMAD, mothers against DPP homolog 2 , MAD (mothers against decapentaplegic, Drosophila) homolog 2 , SMA- and MAD-related protein 2 , SMAD 2 , SMAD family member 2 , mothers against DPP homolog 2 , mothers against decapentaplegic homolog 2 , MAD homolog 2 , Sma- and Mad-related protein 2 , mother against DPP homolog 2 , mothers against decapentaplegic-like 2 , Smad 2 , mad-related protein 2

GENE ID SPECIES
100033843 Equus caballus
496586 Xenopus (Silurana) tropicalis
30639 Danio rerio
4087 Homo sapiens
432023 Xenopus laevis
395247 Gallus gallus
480144 Canis lupus familiaris
100155304 Sus scrofa
516010 Bos taurus
17126 Mus musculus
29357 Rattus norvegicus
455407 Pan troglodytes
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