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Aperçu des produits pour anti-SMAD2 (SMAD2) Anticorps

Full name:
anti-SMAD, Mothers Against DPP Homolog 2 Anticorps (SMAD2)
Chez sont 408 SMAD, Mothers Against DPP Homolog 2 (SMAD2) Anticorps de 29 de différents fournisseurs disponibles. De plus, nous expédions SMAD2 Kits (40) et SMAD2 Protéines (28) et beaucoup plus de produits pour cette protéine. Un total de 496 SMAD2 produits sont actuellement listés.
7120426M23Rik, fj43c06, hMAD-2, hSMAD2, JV18, JV18-1, Madh2, Madr2, mMad2, Smad-2, wu:fj43c06, Xmad2, XSmad2

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anti-Human SMAD2 Anticorps:

anti-Mouse (Murine) SMAD2 Anticorps:

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anti-SMAD2 Anticorps mieux référencés

  1. Human Polyclonal SMAD2 Primary Antibody pour EIA, WB - ABIN401418 : Liapis, Mylona, Alexandrou, Giannopoulou, Nikolaou, Markaki, Keramopoulos, Nakopoulou: Effect of the different phosphorylated Smad2 protein localizations on the invasive breast carcinoma phenotype. dans APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2007 (PubMed)
    Show all 6 references for ABIN401418

  2. Human Polyclonal SMAD2 Primary Antibody pour IF, ELISA - ABIN1531629 : Zhang, Feng, We, Derynck: Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. dans Nature 1996 (PubMed)
    Show all 2 references for ABIN1531629

  3. Human Polyclonal SMAD2 Primary Antibody pour ELISA, WB - ABIN1532648 : Eppert, Scherer, Ozcelik, Pirone, Hoodless, Kim, Tsui, Bapat, Gallinger, Andrulis, Thomsen, Wrana, Attisano: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. dans Cell 1996 (PubMed)
    Show all 2 references for ABIN1532648

  4. Cow (Bovine) Polyclonal SMAD2 Primary Antibody pour WB - ABIN2780721 : Zheng, Zugates, Lu, Shi, Bai, Lee: Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons. dans The EMBO journal 2006 (PubMed)

  5. Human Polyclonal SMAD2 Primary Antibody pour FACS, IF - ABIN391545 : Funaba, Zimmerman, Mathews: Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase. dans The Journal of biological chemistry 2002 (PubMed)

  6. Cow (Bovine) Polyclonal SMAD2 Primary Antibody pour IHC, WB - ABIN2779412 : Antonson, Jakobsson, Almlöf, Guldevall, Steffensen, Gustafsson: RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3. dans The Journal of biological chemistry 2008 (PubMed)

Plus d’anticorps contre SMAD2 partenaires d’interaction

Zebrafish SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. The results of this study found that Bptf (Montrer BPTF Anticorps) and TGF-beta (Montrer TGFB1 Anticorps)/Smad2 mediate nucleosome remodeling to regulate wnt8a (Montrer WNT8A Anticorps) expression and hence neural posteriorization.

  2. Smad2 and Eomesodermin (Montrer EOMES Anticorps) a (Eomesa (Montrer EOMES Anticorps)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (Montrer EOMES Anticorps) forms a general component of the Smad2 signalling complex in zebrafish.

  3. These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.

  4. study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription

  5. Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.

  6. Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Human SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. The nuclear importin (Montrer KPNA4 Anticorps) IPO5 (Montrer IPO5 Anticorps) was identified as a novel interacting protein of SMAD1 (Montrer GARS Anticorps). Overexpression of IPO5 (Montrer IPO5 Anticorps) in various cell lines specifically increases nuclear localization of BMP receptor (Montrer BMPR1A Anticorps)-activated SMADs (R-SMADs) confirming a functional relationship between IPO5 (Montrer IPO5 Anticorps) and BMP but not TGF-beta (Montrer TGFB1 Anticorps) R-SMADs.

  2. Our findings suggest a stronger chondrogenic potential of CD105(+) SMSCs in comparison to that of CD105(-) SMSCs and that CD105 enhances chondrogenesis of SMSCs by regulating TGF-beta (Montrer TGFB1 Anticorps)/Smad2 signaling pathway, but not Smad1 (Montrer GARS Anticorps)/5. Our study provides a better understanding of CD105 with respect to chondrogenic differentiation.

  3. the findings show that TIEG1 (Montrer KLF10 Anticorps) is highly expressed in human keloids and that it directly binds and represses Smad7 (Montrer SMAD7 Anticorps) promoter-mediated activation of TGF-beta (Montrer TGFB1 Anticorps)/Smad2 signaling

  4. A significant association was found between the low expression of inhibitory protein SMAD-7 (Montrer SMAD7 Anticorps) and both zeta-chain-associated protein kinase (Montrer CDK7 Anticorps) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (Montrer GARS Anticorps)/8 and lower SMAD-4 (Montrer SMAD4 Anticorps) expression in chronic lymphocytic leukemia cells

  5. High expression of SMAD2 is associated with colorectal carcinoma.

  6. this study shows that tolfenamic acid inhibits growth of colon cancer cells through downregulation of Smad2

  7. overexpression of miR29b markedly reduced the expression levels of COL1A1 (Montrer COL1A1 Anticorps) and alphaSMA (Montrer ACTA2 Anticorps), and decreased the expression and nuclear accumulation of pSmad2/3.

  8. p-SMAD2/3 proteins were remarkably increased in bladder carcinoma. High p-SMAD2/3 was not statistically associated with clinicopathological characteristics of the patients. Overexpression of hepaCAM (Montrer HEPACAM Anticorps) prevented the p-SMAD2/3 translocation from the cytoplasm to the nucleus in bladder cancer cells. The p-SMAD2/3 pathway is critical for hepaCAM (Montrer HEPACAM Anticorps)-induced cancer cell apoptosis.

  9. silencing NLRC5 (Montrer NLRC5 Anticorps) reduced extracellular matrix expression in keloid fibroblasts through inhibiting the TGF-beta1 (Montrer TGFB1 Anticorps)/Smad (Montrer SMAD1 Anticorps) signaling pathway.

  10. Data indicate the TGF-beta (Montrer TGFB1 Anticorps) pathway regulates the epithelial-to-mesenchymal transition (EMT (Montrer ITK Anticorps)) of gastric cancer cells by increasing the levels of microRNA miRNA-181b to target Timp3 (Montrer TIMP3 Anticorps) via the Smad2/3/4-dependent pathway.

Xenopus laevis SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. E2a (Montrer TCF3 Anticorps) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

  2. GDF11 (Montrer GDF11 Anticorps) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.

  3. XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (Montrer TGFB1 Anticorps) signalling that incorporates elements of previous models together with crosstalking between Smad1 (Montrer SMAD1 Anticorps)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (Montrer SMAD7 Anticorps).

Mouse (Murine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. In conclusion, TGF-beta (Montrer TGFB1 Anticorps) signaling pathway may influence liver fibrosis by incorporating with YB-1 (Montrer YBX1 Anticorps), indicating that YB-1 (Montrer YBX1 Anticorps) could be a potential target for therapies against liver fibrosis.

  2. miR (Montrer MLXIP Anticorps)-27b is an anti-fibrotic microRNA that inhibits fibroblast activation by targeting TGFbeta (Montrer TGFB1 Anticorps) receptor 1 and SMAD2.

  3. hese studies revealed that Smad2 plays an essential role in the development of the growth plate, that both Smads 2 and 3 inhibit Ihh (Montrer IHH Anticorps) expression in the neonatal growth plate, and suggested they accomplish this by binding to distinct SBEs, mediating assembly of distinct repressive complexes.

  4. This study found evidence of increased leukocyte phosphorylated-Smad2/3 staining in both single leukocytes and platelet-leukocyte aggregates in mice that developed aortic valve stenosis, suggesting the presence of increased circulating active TGF-beta1 (Montrer TGFB1 Anticorps).

  5. Data show that muscle-specific (Montrer EIF3K Anticorps) Smad (Montrer SMAD1 Anticorps) proteins Smad2/3-deficient mice exhibited significant resistance to denervation-induced muscle atrophy.

  6. these data demonstrate that the SMI drives ES cells to skeletal muscle via concerted activation of the Wnt (Montrer WNT2 Anticorps) pathway, and inhibition of Smad2/3 signaling and Shh (Montrer SHH Anticorps) pathways.

  7. Arsenite disrupts zinc-dependent TGFbeta2-SMAD2/3 activity during murine cardiac progenitor cell differentiation.

  8. Smad2 and Smad3 (Montrer SMAD3 Anticorps) oppositely modify STAT3 (Montrer STAT3 Anticorps)-induced transcription of IL-17A (Montrer IL17A Anticorps) and retinoic acid receptor (Montrer RARA Anticorps)-related orphan nuclear receptor (Montrer NR1D1 Anticorps), RORgammat encoded by Rorc (Montrer RORC Anticorps), by acting as a co-activator and co-repressor of STAT3 (Montrer STAT3 Anticorps), respectively.

  9. Endoplasmic reticulum stress in hepatic stellar cells promotes liver fibrosis by inducing over expression of SMAD2.

  10. pSmad3L-Ser (Montrer SIGLEC1 Anticorps) signalling correlates with carcinogenesis of colon tumors and this work supports the hypothesis that pSmad2/3L-Thr (Montrer TRH Anticorps) immunostaining-positive cells are cancer stem cells.

SMAD2 profil antigène

Antigen Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with SMAD2

  • SMAD family member 2 (SMAD2) anticorps
  • SMAD family member 2 (smad2) anticorps
  • MAD homolog 2 (Drosophila) (smad2) anticorps
  • SMAD family member 2 (Smad2) anticorps
  • 7120426M23Rik anticorps
  • fj43c06 anticorps
  • hMAD-2 anticorps
  • hSMAD2 anticorps
  • JV18 anticorps
  • JV18-1 anticorps
  • Madh2 anticorps
  • Madr2 anticorps
  • mMad2 anticorps
  • Smad-2 anticorps
  • wu:fj43c06 anticorps
  • Xmad2 anticorps
  • XSmad2 anticorps

Protein level used designations for SMAD2

SMAD, mothers against DPP homolog 2 , MAD (mothers against decapentaplegic, Drosophila) homolog 2 , SMA- and MAD-related protein 2 , SMAD 2 , SMAD family member 2 , mothers against DPP homolog 2 , mothers against decapentaplegic homolog 2 , MAD homolog 2 , Sma- and Mad-related protein 2 , mother against DPP homolog 2 , mothers against decapentaplegic-like 2 , Smad 2 , mad-related protein 2

100033843 Equus caballus
496586 Xenopus (Silurana) tropicalis
30639 Danio rerio
4087 Homo sapiens
432023 Xenopus laevis
395247 Gallus gallus
480144 Canis lupus familiaris
100155304 Sus scrofa
516010 Bos taurus
17126 Mus musculus
29357 Rattus norvegicus
455407 Pan troglodytes
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