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anti-Human SMAD2 Anticorps:
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Human Monoclonal SMAD2 Primary Antibody pour IF, IP - ABIN968106
Babu, Jeganathan, Baker, Wu, Kang-Decker, van Deursen: Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. dans The Journal of cell biology 2003
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Human Monoclonal SMAD2 Primary Antibody pour IF, IP - ABIN968105
Chen, Waters, Salmon, Murray: Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. dans Science (New York, N.Y.) 1996
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Human Polyclonal SMAD2 Primary Antibody pour WB - ABIN2801941
Liu, Pouponnot, Massagué: Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. dans Genes & development 1998
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Human Monoclonal SMAD2 Primary Antibody pour ICC, FACS - ABIN969401
Wendt, Smith, Schiemann: p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity. dans The Journal of biological chemistry 2009
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Human Polyclonal SMAD2 Primary Antibody pour IHC (p), IHC - ABIN316295
Lee, Lee, Bae, Jung: Abnormal liver differentiation and excessive angiogenesis in mice lacking Runx3. dans Histochemistry and cell biology 2013
Human Polyclonal SMAD2 Primary Antibody pour WB - ABIN362416
Kim, Jong, Kim, Lee, Kim, Hong, Bang: Transforming growth factor-beta 1 induces apoptosis through Fas ligand-independent activation of the Fas death pathway in human gastric SNU-620 carcinoma cells. dans Molecular biology of the cell 2004
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Human Polyclonal SMAD2 Primary Antibody pour ELISA, WB - ABIN257079
Eppert, Scherer, Ozcelik, Pirone, Hoodless, Kim, Tsui, Bapat, Gallinger, Andrulis, Thomsen, Wrana, Attisano: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. dans Cell 1996
Human Polyclonal SMAD2 Primary Antibody pour WB - ABIN1842518
Song, Thalacker, Nilsen-Hamilton: Synergistic and multidimensional regulation of plasminogen activator inhibitor type 1 expression by transforming growth factor type ? and epidermal growth factor. dans The Journal of biological chemistry 2012
Human Monoclonal SMAD2 Primary Antibody pour IF, IHC (p) - ABIN517619
Talvinen, Tuikkala, Nykänen, Nieminen, Anttinen, Nevalainen, Hurme, Kuopio, Kronqvist: Altered expression of p120catenin predicts poor outcome in invasive breast cancer. dans Journal of cancer research and clinical oncology 2010
Human Monoclonal SMAD2 Primary Antibody pour FACS, IF - ABIN967045
Hannan, Jamshidi, Pera, Wolvetang: BMP-11 and myostatin support undifferentiated growth of human embryonic stem cells in feeder-free cultures. dans Cloning and stem cells 2009
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The non-Smad (Montrer SMAD1 Anticorps) JNK (Montrer MAPK8 Anticorps) signaling pathway, which is downstream of Nodal signaling, regulates nuclear movement independently of the Smad (Montrer SMAD1 Anticorps) pathway, and this nuclear movement is associated with Smad (Montrer SMAD1 Anticorps) signal transduction toward the nucleus.
The results of this study found that Bptf (Montrer BPTF Anticorps) and TGF-beta (Montrer TGFB1 Anticorps)/Smad2 mediate nucleosome remodeling to regulate wnt8a (Montrer WNT8A Anticorps) expression and hence neural posteriorization.
Smad2 and Eomesodermin (Montrer EOMES Anticorps) a (Eomesa (Montrer EOMES Anticorps)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (Montrer EOMES Anticorps) forms a general component of the Smad2 signalling complex in zebrafish.
These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.
study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription
Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.
Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis
CRT (Montrer SLC6A8 Anticorps) regulates TGF-beta1 (Montrer TGFB1 Anticorps)-induced-EMT (Montrer ITK Anticorps) through modulating Smad (Montrer SMAD1 Anticorps) signaling
P311 (Montrer C5orf13 Anticorps) is a novel TGFbeta1 (Montrer TGFB1 Anticorps)/Smad (Montrer SMAD1 Anticorps) signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing.
human epidermal growth factor receptor (Montrer EGFR Anticorps) 2 (HER-2 (Montrer ERBB2 Anticorps)) levels, were correlated well with TSP50 (Montrer PRSS50 Anticorps)/p-Samd2 (Montrer SARM1 Anticorps)/3 and TSP50 (Montrer PRSS50 Anticorps)/p27 (Montrer PAK2 Anticorps) expression status. Thus, our studies revealed a novel regulatory mechanism underlying TSP50 (Montrer PRSS50 Anticorps)-induced cell proliferation and provided a new favorable intervention target for the treatment of breast cancer
IL-17 (Montrer IL17A Anticorps) can induce A549 alveolar epithelial cells to undergo epithelial-mesenchymal transition via the TGF-beta1 (Montrer TGFB1 Anticorps) mediated Smad2/3 and ERK1/2 (Montrer MAPK1/3 Anticorps) activation
a critical role for miR (Montrer MLXIP Anticorps)-503-3p in induction of breast cancer EMT (Montrer ITK Anticorps)
Nuclear localization of Smad2 was reduced in TGFbeta (Montrer TGFB1 Anticorps)-1-stimulated primary tubular epithelial cells. Changes in nuclear Smad2 correlated with a reduced expression of the pro-fibrotic factor CTGF (Montrer CTGF Anticorps). Transient downregulation of Smad2 interfered with TGFbeta (Montrer TGFB1 Anticorps)-1-induced CTGF (Montrer CTGF Anticorps) synthesis.
Low SMAD2 expression is associated with progression of hepatic fibrosis.
In order to study the translation between mouse model and patients, we evaluated the signature of phosphorylated Sma- and Mad-related protein 2 (pSmad2), as molecular marker of TGF-beta/activin activity, in the kidneys of streptozotocin (STZ)-treated mice compared to that of type 1 diabetes (T1D) patients.
SMAD2/SMAD3 (Montrer SMAD3 Anticorps) signaling by bone morphogenetic proteins causes disproportionate induction of HAS2 (Montrer HAS2 Anticorps) expression and hyaluronan production in immortalized human granulosa cells.
miR (Montrer MLXIP Anticorps)-27a contributed to cell proliferation and invasion by inhibiting TGF-beta (Montrer TGFB1 Anticorps)-induced cell cycle arrest. These results suggest that miR (Montrer MLXIP Anticorps)-27a may function as an oncogene (Montrer RAB1A Anticorps) by regulating SMAD2 and SMAD4 (Montrer SMAD4 Anticorps) in lung cancer.
Grg4 (Montrer TLE4 Anticorps) occupancy at the Xnr1 (Montrer NODAL Anticorps) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 (Montrer TLE4 Anticorps) from FoxH1 (Montrer FOXH1 Anticorps) at the Xnr1 (Montrer NODAL Anticorps) enhancer, an essential feature of the transcriptional switch mechanism.
E2a (Montrer TCF3 Anticorps) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis
GDF11 (Montrer GDF11 Anticorps) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.
XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.
Activin A (Montrer INHBA Anticorps) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (Montrer NANOG Anticorps) and OCT4 (Montrer POU5F1 Anticorps),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (Montrer NANOG Anticorps)/OCT4 (Montrer POU5F1 Anticorps) expression.
the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis
Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.
a detailed computational model for TGF-beta (Montrer TGFB1 Anticorps) signalling that incorporates elements of previous models together with crosstalking between Smad1 (Montrer SMAD1 Anticorps)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (Montrer SMAD7 Anticorps).
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3 (Montrer TPM1 Anticorps), as a model of immature Leydig cells.
Lnc-LFAR1 binds directly to Smad2/3 and promotes transcription of TGFbeta (Montrer TGFB1 Anticorps), Smad2, Smad3 (Montrer SMAD3 Anticorps), Notch2 (Montrer NOTCH2 Anticorps) and Notch3 (Montrer NOTCH3 Anticorps) which, in turn, results in TGFbeta (Montrer TGFB1 Anticorps) and Notch (Montrer NOTCH1 Anticorps) pathway activation.
the levels of Smad2/3, P-Smad2/3 expressions were decreased, while the level of Smad7 (Montrer SMAD7 Anticorps) expression was increased after treatment with osthole.
These findings implicate TGF-beta (Montrer TGFB1 Anticorps)-Smad2/3 signaling in activated tissue-resident cardiac fibroblasts as principal mediators of the fibrotic response.
selective inhibition of SMAD3 (Montrer SMAD3 Anticorps) or CCT6A (Montrer CCT6A Anticorps) efficiently suppresses TGF-beta (Montrer TGFB1 Anticorps)-mediated metastasis. Findings provide a mechanism that directs TGF-beta (Montrer TGFB1 Anticorps) signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta (Montrer TGFB1 Anticorps) for non-small-cell lung carcinoma.
results demonstrate that TGF-beta1 (Montrer TGFB1 Anticorps)-induced autophagy links beta-catenin (Montrer CTNNB1 Anticorps) and Smad (Montrer SMAD1 Anticorps) signaling to promote epithelial-mesenchymal transition in C1.1 cells through a novel pY654-beta-catenin (Montrer CTNNB1 Anticorps)/p-Smad2/ILK (Montrer ILK Anticorps) pathway.
These results suggest that Nedd9 (Montrer NEDD9 Anticorps) is a Smad2/3 target gene implicated in RANKL (Montrer TNFSF11 Anticorps)-induced osteoclastogenesis.
In conclusion, TGF-beta (Montrer TGFB1 Anticorps) signaling pathway may influence liver fibrosis by incorporating with YB-1 (Montrer YBX1 Anticorps), indicating that YB-1 (Montrer YBX1 Anticorps) could be a potential target for therapies against liver fibrosis.
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.
SMAD, mothers against DPP homolog 2
, MAD (mothers against decapentaplegic, Drosophila) homolog 2
, SMA- and MAD-related protein 2
, SMAD 2
, SMAD family member 2
, mothers against DPP homolog 2
, mothers against decapentaplegic homolog 2
, MAD homolog 2
, Sma- and Mad-related protein 2
, mother against DPP homolog 2
, mothers against decapentaplegic-like 2
, Smad 2
, mad-related protein 2