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SLC25A22 is an important mitochondrial glutamate transporter (Montrer SLC1A1 Kits ELISA).
SLC25A22 promotes proliferation and migration of colorectal cancer (CRC (Montrer CALR Kits ELISA)) cells with KRAS mutations, and formation and metastasis of CRC (Montrer CALR Kits ELISA) xenograft tumors in mice. Patients with colorectal tumors expressing increased levels of SLC25A22 have shorter survival times. SLC25A22 induces intracellular synthesis of aspartate.
SLC25A22 is responsible for migrating partial seizures in infancy, demonstrated by combining linkage analysis and whole exome sequencing.
Compares and contrasts all the known human SLC25A (Montrer SLC25A25 Kits ELISA)* genes and includes functional information.
A novel SLC25A22 mutation in an unrelated patient born from first cousin Algerian parents and presenting severe epileptic encephalopathy, is described.
This gene encodes a mitochondrial glutamate carrier. Mutations in this gene are associated with early infantile epileptic encephalopathy. Multiple alternatively spliced variants, encoding the same protein, have been identified.
glutamate/H(+) symporter 1
, mitochondrial glutamate carrier 1
, solute carrier family 25 member 22
, solute carrier family 25 (mitochondrial carrier, glutamate), member 22