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Bird (Avian) Polyclonal TH Primary Antibody pour ICC, IF - ABIN152459
Guo, Lai, Longhurst: Medullary pathways involved in cardiac sympathoexcitatory reflexes in the cat. dans Brain research 2001
Show all 47 Pubmed References
Fruit Fly (Drosophila melanogaster) Polyclonal TH Primary Antibody pour ICC, IF - ABIN152458
Renfroe, Chronister, Haycock, Waymire: The localization of tyrosine hydroxylase-like immunoreactivity in the central nervous system: methodological considerations. dans Brain research bulletin 1984
Show all 68 Pubmed References
Alpaca (Vicugna pacos) Monoclonal TH Primary Antibody pour IEM, ICC - ABIN617906
Lundius, Stroth, Vukojević, Terenius, Svenningsson: Functional GPR37 trafficking protects against toxicity induced by 6-OHDA, MPP+ or rotenone in a catecholaminergic cell line. dans Journal of neurochemistry 2013
Show all 1421 Pubmed References
Human Monoclonal TH Primary Antibody pour IHC (fro), IHC (p) - ABIN3043094
Huang, Zhu, Zhang, Zhu, Liu, Zhu, Wang, Li, Yang, Dong, Liu, Chen, Zhang, Yang, Deng, Fan, Wang, Liu, Ma, Fu, Wu: S100+ cells: a new neuro-immune cross-talkers in lymph organs. dans Scientific reports 2013
Show all 9 Pubmed References
Mammalian Polyclonal TH Primary Antibody pour IHC (fro), IF - ABIN361503
Nakashima, Mori, Kaneko, Hayashi, Nagatsu, Ota: Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme. dans Biochemical and biophysical research communications 2011
Show all 15 Pubmed References
Mouse (Murine) Polyclonal TH Primary Antibody pour ICC, IHC (fro) - ABIN152518
Lew, Garcia-Espana, Lee, Carr, Goldstein, Haycock, Meller: Increased site-specific phosphorylation of tyrosine hydroxylase accompanies stimulation of enzymatic activity induced by cessation of dopamine neuronal activity. dans Molecular pharmacology 1999
Show all 5 Pubmed References
Rat (Rattus) Polyclonal TH Primary Antibody pour IHC (fro), IF - ABIN361502
Kish, Kalasinsky, Derkach, Schmunk, Guttman, Ang, Adams, Furukawa, Haycock: Striatal dopaminergic and serotonergic markers in human heroin users. dans Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001
Show all 12 Pubmed References
Mouse (Murine) Polyclonal TH Primary Antibody pour IF, IHC - ABIN152552
Salvatore, Garcia-Espana, Goldstein, Deutch, Haycock: Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds. dans Journal of neurochemistry 2000
Show all 4 Pubmed References
Human Monoclonal TH Primary Antibody pour ICC, IF - ABIN151520
Zhang, Ng, Li, He, Anderson, Sun, Zhou: Prokineticin 2 is a target gene of proneural basic helix-loop-helix factors for olfactory bulb neurogenesis. dans The Journal of biological chemistry 2007
Show all 3 Pubmed References
Rat (Rattus) Polyclonal TH Primary Antibody pour ICC, IHC (fro) - ABIN152553
Andres-Mateos, Perier, Zhang, Blanchard-Fillion, Greco, Thomas, Ko, Sasaki, Ischiropoulos, Przedborski, Dawson, Dawson: DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. dans Proceedings of the National Academy of Sciences of the United States of America 2007
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The Khc73 stalk/14-3-3 (Montrer YWHAZ Anticorps)/NudE pathway defines a physical connection that coordinates the activities of multiple motor proteins to precisely position the spindle.
role of 14-3-3epsilon in germ cell migration
14-3-3epsilon acts as a biochemical control point for axon guidance in Drosophila, silencing Plexin A repulsive axon guidance and regulating a semaphorin repulsion/integrin adhesion switch.
We conclude that 14-3-3epsilon is required for Rab11 (Montrer RAB11A Anticorps)-positive vesicle function, which in turn enables antimicrobial peptide (Montrer cAMP Anticorps) secretion during an innate immune response.
Hpo (Montrer GFER Anticorps) signaling inhibited Yki (Montrer YAP1 Anticorps) nuclear localization and activity by phosphorylating Yki (Montrer YAP1 Anticorps) and both isoforms of 14-3-3 (Montrer YWHAZ Anticorps), 14-3-3varepsilon and 14-3-3zeta (Montrer YWHAZ Anticorps), regulate Yki (Montrer YAP1 Anticorps) activity through modulating its subcellular localization.
The biochemically conserved regulatory mechanisms of recombinant DTH parallel those from mammals.
maternal as well as embryonic effects on the secretion and/or functionality of Tyrosine hydroxylase (pale) may play roles in the early developmental program of the organism.
activity of tyrosine hydroxylase is also increased by this interaction, in excess (Montrer RCC1 Anticorps) of the stimulation resulting from phosphorylation alone
Drosophila 14-3-3/PAR-5 (Montrer YWHAZ Anticorps) is an essential mediator of PAR-1 (Montrer F2R Anticorps) function in axis formation.
PAR-1 (Montrer F2R Anticorps) phosphorylates Bazooka/PAR-3 (Montrer PARD3 Anticorps) on two conserved serines to generate 14-3-3 (Montrer YWHAZ Anticorps) binding sites. This inhibits formation of the Bazooka (Montrer PARD3 Anticorps)/PAR-6 (Montrer PARD6A Anticorps)/aPKC complex by blocking Bazooka (Montrer PARD3 Anticorps) oligomerization and binding to aPKC.
Data suggest that TH phosphorylated at Ser (Montrer SIGLEC1 Anticorps)-31 co-distributes with Golgi complexes and synaptic-like vesicles in rat and human dopaminergic neurons/cell lines; Ser (Montrer SIGLEC1 Anticorps)-31 phosphorylation may regulate TH subcellular localization by enabling its transport along microtubules, notably toward the projection terminals.
TH is a robust interaction partner of different 14-3-3 (Montrer YWHAQ Anticorps) dimer types with moderate variability between the 14-3-3 (Montrer YWHAQ Anticorps) dimers on their regulation of TH.
No statistically significant differences were found between cases and controls for the allele frequencies in five genes: TH, SLC18A2, DRD1 (Montrer DRD1 Anticorps), DRD3 (Montrer DRD3 Anticorps) and COMT (Montrer COMT Anticorps). Conversely, some alleles of the 12 sNPs from the DRD2 (Montrer DRD2 Anticorps) locus and the 5 from the MAOA (Montrer MAOA Anticorps) locus showed significant associations with excessive alcohol consumption.
Results show that metastasis-associated protein 1 (MTA1 (Montrer MTA1 Anticorps)) and tyrosine hydroxylase (TH) levels were significantly down-regulated in Parkinson disease (PD) samples as compared with normal brain tissue
the reduction of tyrosine hydroxylase-immunoreactive neurons occurring in the locus coeruleus after perinatal hypoxic insults persists into adulthood
In high-risk metastatic Neuroblastoma (Montrer ARHGEF16 Anticorps), TH and DCX (Montrer DCX Anticorps) mRNA quantification could be used for the assessment of response to treatment and for early detection of progressive disease or relapses.
the allelic frequency of the TH01 marker in 171 Swiss sudden infant death syndrome (SIDS (Montrer IDS Anticorps)) infants and 500 healthy and gender-matched Caucasian adults showed that the 9.3 allele is similarly distributed in SIDS (Montrer IDS Anticorps) cases and controls (27.2% vs. 25.6%; p-value = 0.562).
This study showed that a new tyrosine hydroxylase knock-in mouse model of l-DOPA-responsive dystonia.
The mutant tyrosine hydroxylase enzyme was unstable and exhibited deficient stabilization by catecholamines, leading to decline of brain tyrosine hydroxylase-immunoreactivity in the Th knock-in mice.
Thus, the hTH-GFP reporter rat should be a valuable tool for Parkinson's disease research.
These findings reveal that Th and Gad1 share a transcription regulatory mechanism that facilitates odorant-dependent regulation of dopamine and GABA expression levels.
deletion of Th in hematopoietic cells of adult mice neither alters energy expenditure upon cold exposure nor reduces browning in inguinal adipose tissue. Bone marrow-derived macrophages did not release NE in response to stimulation with IL-4 (Montrer IL4 Anticorps), and conditioned media from IL-4 (Montrer IL4 Anticorps)-stimulated macrophages failed to induce expression of thermogenic genes, such as uncoupling protein 1 (Ucp1 (Montrer UCP1 Anticorps)), in adipocytes.
The neurogenic contractions were higher in the sickle cell disease, in association with elevated tyrosine hydroxylase phosphorylated at Ser (Montrer SIGLEC1 Anticorps)-31 and total tyrosine hydroxylase protein expression, as well as increased tyrosine hydroxylase mRNA expression.
these data demonstrate a novel interaction between Hsc70 (Montrer HSPA8 Anticorps) and TH that regulates the activity and localization of the enzyme to synaptic vesicles, suggesting an important role for Hsc70 (Montrer HSPA8 Anticorps) in dopamine homeostasis.
TH gene overexpression promotes the polarization and differentiation of CD4 (Montrer CD4 Anticorps)+ cells towards Th2 cells.
The TH-immunopositive fibres detected in the orbitofrontal cortices of the DISC1 (Montrer DISC1 Anticorps) KO mice were significantly shorter than those seen in the wild-type mice.
Real-time PCR analyses revealed that social defeat significantly increased tyrosine hydroxylase in the ventral tegmental area.
These results revealed a new role of the canonical Lrp5 (Montrer LRP5 Anticorps)/6-beta-catenin (Montrer CTNNB1 Anticorps) pathway in regulating the morphogenesis of the cerebellum during postnatal development.
psychostimulants induce downregulation of DRD1a (Montrer DRD1 Anticorps) and DRD2 (Montrer DRD2 Anticorps) mRNA expression and upregulation of tyrosine hydroxylase protein expression in the testis
Deletion of the CB2 r (Montrer CNR2 Anticorps) gene increased preference for and vulnerability to ethanol consumption, at least in part, by increased ethanol-induced sensitivity of the TH and mu-opioid receptor (Montrer OPRM1 Anticorps) gene expressions in mesolimbic neurons.
Achilles tendon tenocytes produce tyrosine hydroxylase.
Retinol activates tyrosine hydroxylase via two sequential non-genomic mechanisms, which have not previously been characterized. These mechanisms are likely to operate in vivo to facilitate the stress response.
IFN-alpha (Montrer IFNA Anticorps) mediated activation of ERK1/2 (Montrer MAPK1/3 Anticorps) appeared to be responsible for the increased phosphorylation of tyrosine hydroxylase.
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
, XBB70 group VII
, drosophila tyrosine hydroxylase
, tyrosine hydrodroxylase
, tyrosine hydroxylase
, tyrosine 3-monooxygenase
, suppressor of Ras85D 3-9
, dystonia 14
, tyrosine 3-hydroxylase