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Aperçu des produits pour Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Kits ELISA

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Adrenergic, Beta, Receptor Kinase 1 Kits ELISA (ADRBK1)
Chez sont 15 Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Kits ELISA de 8 de différents fournisseurs disponibles. De plus, nous expédions Adrenergic, Beta, Receptor Kinase 1 Anticorps (130) et Adrenergic, Beta, Receptor Kinase 1 Protéines (9) et beaucoup plus de produits pour cette protéine. Un total de 169 Adrenergic, Beta, Receptor Kinase 1 produits sont actuellement listés.
Adrbk-1, Bark-1, BARK1, BETA-ARK1, betaARK1, GRK-2, Grk2

Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Kits ELISA par réactivité

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Plus Kits ELISA pour Adrenergic, Beta, Receptor Kinase 1 partenaires d'interaction

Mouse (Murine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. GRK2 down-regulation is cardioprotective during diet-induced obesity, reinforcing the protective effect of maintaining low levels of GRK2 under nutritional stress, and showing a role for this kinase in obesity-induced cardiac remodeling and steatosis.

  2. The betaARKrgs peptide, but not endogenous GRK2, interacted with Galpha(q (Montrer GNAQ Kits ELISA)) and interfered with signaling through this G protein. These data support the development of GRK2-based therapeutic approaches to prevent hypertrophy and heart failure.

  3. GRK2 is localized in the mitochondria and its kinase activity negatively impacts the function of this organelle by increasing superoxide levels and altering substrate utilization for energy production.

  4. Erythropoietin (Montrer EPO Kits ELISA) seems to reverse sepsis-induced vasoplegia to NE through the preservation of alpha1D adrenoceptor mRNA/protein expression, inhibition of GRK2-mediated desensitization, and attenuation of NO overproduction in the mouse aorta.

  5. In vitro, GRK2 inhibits Epac1 (Montrer RAPGEF3 Kits ELISA)-to-Rap1 (Montrer TERF2IP Kits ELISA) signaling by phosphorylation of Epac1 (Montrer RAPGEF3 Kits ELISA) at Ser (Montrer SIGLEC1 Kits ELISA)-108 in the Disheveled/Egl-10/pleckstrin (Montrer PLEK Kits ELISA) domain. GRK2 inhibits Epac1 (Montrer RAPGEF3 Kits ELISA)-mediated sensitization of Piezo2 (Montrer FAM38B Kits ELISA) which contributes to inflammatory mechanical hyperalgesia.

  6. GRK2 ablation increases circadian amplitude and decreases circadian period. GRK2 suppresses mPeriod1 transcription,PERIOD1/2 nuclear trafficking and promotes PERIOD2 phosphorylation.

  7. These results suggest GRK2 contributes to melanopsin (Montrer OPN4 Kits ELISA) deactivation, but that other mechanisms account for most of modulation of melanopsin (Montrer OPN4 Kits ELISA) activity in ipRGCs.

  8. data suggest that inhibiting GRK2 could reverse an established insulin (Montrer INS Kits ELISA)-resistant and obese phenotype

  9. Post-MI AdipoR1 (Montrer ADIPOR1 Kits ELISA) phosphorylation positively correlated with the expression level of GRK2. AdipoR1 (Montrer ADIPOR1 Kits ELISA) is phosphorylatively modified and desensitized by GRK2 in failing cardiomyocytes, contributing to post-MI remodeling and HF progression.

  10. findings indicate that the balance between mechanisms regulating vascular tone are shifted to favor vasoconstriction in the absence of GRK2 expression and that this leads to the age-dependent development of hypertension

Cow (Bovine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. Mitochondrial-targeted GRK2 is essential for prodeath signaling occurring after oxidative stress in myocytes and assigning a novel role for this GRK (Montrer GRK4 Kits ELISA).

  2. Indicate that the anti-proliferative function of elevated GRK2 in hepatocellular carcinoma is associated with delayed cell cycle progression and is GRK2 kinase activity-dependent.

  3. G alpha q/11 interacts with this protein. A novel surface on a regulator of G protein signals a homology domain for binding G alpha subunits (GRK2 kinase}

  4. determined the crystallographic structure of GRK2 in complex with G protein beta1gamma2 subunits.

  5. intramolecular interactions could play a role in regulating G protein-coupled receptor kinase 2 (GRK2).

  6. epithelial Na-channels are maintained in the active state by Grk2; Grk2 phosphorylates the C terminus of the channel beta subunit and renders the channels insensitive to inhibition by Nedd4-2.

  7. Crystallographic and biochemical studies provide evidence that the major domain interfaces of G protein-coupled beta adrenergic receptor kinase 1 (GRK2) remain associated during Gbetagamma binding and activation of GRK2.

  8. Resultrs suggest that activated platelet-derived growth factor receptor-beta (Montrer PDGFRB Kits ELISA) (PDGFRbeta) phosphorylates GRK2 tyrosyl residues and thereby activates GRK2, which then serine-phosphorylates and desensitizes the PDGFRbeta.

  9. GRK2-as5 has a role in membrane trafficking of the mu-opioid receptor (Montrer OPRM1 Kits ELISA)

  10. atomic structure of GRK2 in complex with Galphaq (Montrer GNAQ Kits ELISA) and Gbetagamma, in which activated Galpha (Montrer SUCLG1 Kits ELISA) subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [Galphaq (Montrer GNAQ Kits ELISA), Gbetagamma

Human Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. Our data suggest that GRK2 acts as an important onco-modulator by strengthening the functionality of key players in breast tumorigenesis such as HDAC6 (Montrer HDAC6 Kits ELISA) and Pin1 (Montrer PIN1 Kits ELISA).

  2. GRK2 may inhibit IGF1 (Montrer IGF1 Kits ELISA)-induced human hepatocellular carcinoma cell growth and migration through downregulation of EGR1 (Montrer EGR1 Kits ELISA).

  3. It is a critical factor in diabetic endothelial dysfunction and plays a role in many physiological functions including regulation of G-protein-coupled receptors (GPCRs). (review)

  4. Suggest a common regulatory pattern for the beta(2)-AR/GRK2 which is independent of cellular type or pathology.

  5. Suggest role for GRK2 in the regulating cardiac hypertrophy.

  6. the dual-specific GRK2 and ERK (Montrer EPHB2 Kits ELISA) cascade inhibitor, RKIP (Raf kinase inhibitor protein (Montrer PEBP1 Kits ELISA)), triggered dysfunctional cardiomyocyte energetics and the expression of heart failure-promoting Pparg (Montrer PPARG Kits ELISA)-regulated genes.

  7. Acute mental stress significantly increased GRK2 density in in peripheral blood mononuclear cells of young adult males.

  8. It plays a role in progression of Vasculature which is affected by insulin (Montrer INS Kits ELISA) resistance and type 2 diabetes expresses high levels of GRK2

  9. Data suggest that, by targeting/repressing GRK2, microRNA-K3 of Kaposi sarcoma-associated herpesvirus (KSHV) facilitates migration and invasion of vascular endothelial cells via activation of CXCR2 (Montrer CXCR2 Kits ELISA)/AKT (Montrer AKT1 Kits ELISA) signaling.

  10. Acute aerobic exercise induces a greater GRK2 expression in women than men, while increased cardiorespiratory fitness is associated with exercise-induced GRK2 expression in PBMCs

Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) profil antigène

Antigen Summary

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

Alternative names and synonyms associated with Adrenergic, Beta, Receptor Kinase 1 (ADRBK1)

  • beta-adrenergic receptor kinase 1 (Tsp_00497) Elisa Kit
  • adrenergic, beta, receptor kinase 1 (adrbk1) Elisa Kit
  • adrenergic receptor kinase, beta 1 (Adrbk1) Elisa Kit
  • adrenergic, beta, receptor kinase 1 (ADRBK1) Elisa Kit
  • adrenergic, beta, receptor kinase 1 (Adrbk1) Elisa Kit
  • Adrbk-1 Elisa Kit
  • Bark-1 Elisa Kit
  • BARK1 Elisa Kit
  • BETA-ARK1 Elisa Kit
  • betaARK1 Elisa Kit
  • GRK-2 Elisa Kit
  • Grk2 Elisa Kit

Protein level used designations for ADRBK1

beta-adrenergic receptor kinase 1 , adrenergic, beta, receptor kinase 1 , G-protein-coupled receptor kinase 2 , beta ARK , beta ARK1 , beta-AR kinase-1 , beta-ARK-1 , beta-adrenergic receptor kinase-1 , G-protein coupled receptor kinase 2 , adrenergic receptor kinase, beta 1 , beta-adrenergic receptor kinase 1 beta ARK1

10901826 Trichinella spiralis
100555775 Anolis carolinensis
110355 Mus musculus
282682 Bos taurus
156 Homo sapiens
25238 Rattus norvegicus
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