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Human Polyclonal STAM2 Primary Antibody pour ELISA, WB - ABIN251316
Pandey, Fernandez, Steen, Blagoev, Nielsen, Roche, Mann, Lodish: Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. dans The Journal of biological chemistry 2001
Show all 2 Pubmed References
Human Polyclonal STAM2 Primary Antibody pour IHC, IHC (p) - ABIN4356186
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. dans Nature methods 2013
The G-102A polymorphism in STAM2 is significantly associated with withers height, heart girth, cannon circumference, chest width, and hip height in Wuchuan Black cattle
SLBP (Montrer SLBP Anticorps) is a potentially important cellular regulator of HIV-1, thereby establishing a link between histone metabolism, inflammation, and HIV-1 infection
showed that inhibiting the SLBP (Montrer SLBP Anticorps) mRNA and protein levels were rescued by epigenetic modifiers suggesting that nickel's effects on SLBP (Montrer SLBP Anticorps) may be mediated via epigenetic mechanisms
Cyclin F (Montrer CCNF Anticorps)-mediated degradation of SLBP (Montrer SLBP Anticorps) limits H2A.X (Montrer H2AFX Anticorps) accumulation and apoptosis upon genotoxic stress in G2 cell cycle checkpoint.
CRL4(WDR23 (Montrer DCAF11 Anticorps)) is required for efficient histone mRNA 3' end processing to produce mature histone mRNAs for translation. CRL4(WDR23 (Montrer DCAF11 Anticorps)) binds and ubiquitylates SLBP (Montrer SLBP Anticorps) in vitro and in vivo, and this modification activates SLBP (Montrer SLBP Anticorps) function in histone mRNA 3' end processing without affecting its protein levels.
FEM1 proteins are ancient regulators of Stem-Loop Binding Protein (Montrer SLBP Anticorps).
CRL4-DCAF11 (Montrer DCAF11 Anticorps) mediates the degradation of SLBP (Montrer SLBP Anticorps) at the end of S phase and this degradation is essential for the viability of cells.
The authors propose a structural organization where the AMSH (Montrer STAMBP Anticorps)-SH3 binding motif interacts with the STAM2-SH3 domain (Montrer ITSN1 Anticorps) and contributes to the correct positioning of AMSH (Montrer STAMBP Anticorps) prior to polyubiquitin (Montrer UBB Anticorps) chains' cleavage.
The VHS domain of STAM2 directs AMSH to cleave longer Lys63-linked ubiquitin chains
homologous domain of human Bro1 (Montrer HMGCR Anticorps) domain-containing proteins, Alix (Montrer PDCD6IP Anticorps) and Brox, binds CHMP4B (Montrer CHMP4A Anticorps) but not STAM2, despite their high structural similarity
arsenic, a carcinogenic metal, decreases cellular levels of SLBP (Montrer SLBP Anticorps) by inducing its proteasomal degradation and inhibiting SLBP (Montrer SLBP Anticorps) transcription via epigenetic mechanisms
Stam2 is expressed in the nervous tissue, heart, digestive and endocrine system during embryo development.
These results demonstrate that the STAMs are indispensably involved in T-cell development and survival in the thymus through the prevention of apoptosis but are dispensable for the proximal signaling of TCR and cytokine receptors.
STAM (Montrer STAM Anticorps) proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway.
SH3 domains of STAM2 and Grb2 (Montrer GRB2 Anticorps) retain the moderate characteristics of recognizing their ligand proteins like other SH3 domains for signal protein (Montrer KLK7 Anticorps) binding
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.
, Hrs-binding protein
, STAM-like protein containing SH3 and ITAM domains 2
, signal transducing adapter molecule 2
, Hrs binding protein
, hrs-binding protein
, signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
, EAST protein
, epidermal growth factor receptor-associated protein with SH3 and TAM domain
, signal transducing adaptor molecule 2
, signal transducing adapter molecule 2-like