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In summary, our study revealed a negative regulation of the UPR transducer ATF6 through post-translational SUMOylation. The information from this study will not only increase our understanding of the fine-tuning regulation of the UPR signaling but will also be informative to the modulation of the UPR for therapeutic benefits.
Low ATF6 expression is associated with cancer.
Activating transcription factor 6 (ATF6alpha) pathway and ER-associated protein degradation (ERAD) are elevated in salivary glands of Sjogren's syndrome patients (SS).
A transcription factor complex consisting of ATF6 (an endoplasmic reticulum-resident factor) and C/EBP-beta (Montrer CEBPB Kits ELISA) is required for the IFN-gamma-induced (Montrer SAMHD1 Kits ELISA) expression of DAPK1 (Montrer DAPK1 Kits ELISA) IFN-gamma-induced (Montrer SAMHD1 Kits ELISA) proteolytic processing of ATF6 and phosphorylation of C/EBP-beta (Montrer CEBPB Kits ELISA) are obligatory for the formation of this transcriptional complex
Authors observed the cleavage of ATF6, the phosphorylation of MRLC, and the expression of death-associated protein kinase (DAPK1 (Montrer DAPK1 Kits ELISA)) by western blotting; the transcription of DAPK1 (Montrer DAPK1 Kits ELISA) by RT-PCR; and the subcellular localization of ATF6 and mAtg9 (Montrer ATG9A Kits ELISA) by immunofluorescence.
Genetic Variations in ATF6 (rs2070150) is not Associated with Hepatocellular Carcinoma in Thai Patients with Hepatitis B Virus Infection.
We found that HCS (Montrer HLCS Kits ELISA) identified compounds which inhibited ATF6 nuclear translocation with high specificity, as confirmed by the luciferase reporter assay and western blot analysis
results identify a role for DREAM silencing in the activation of ATF6 signaling, which promotes early neuroprotection in HD.
Endoplasmic reticulum stress related factor ATF6 and caspase-12 (Montrer CASP12 Kits ELISA) trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.
Defective podocyte insulin (Montrer INS Kits ELISA) signaling through p85-XBP1 (Montrer XBP1 Kits ELISA) promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.
ATF6 is essential for ER stress-mediated SESN2 (Montrer SESN2 Kits ELISA) induction.
Forced activation of the ATF6 UPR branch reduced infarct volume and improved functional outcome at 24 h after stroke
However, depletion of XBP1 (Montrer XBP1 Kits ELISA) and ATF6, alone or in combination, prevented autophagy induction and significantly enhanced Japanese encephalitis virus-induced cell death.
Deletion of Atf6alpha suppressed inflammation, and ameliorated demyelination after experimental autoimmune encephalomyelitis.
we show that overexpression of the dominant-negative form of ATF6 (dnATF6) increases susceptibility to develop hepatic steatosis in diet-induced insulin (Montrer INS Kits ELISA)-resistant mice and fasted mice. Furthermore, hepatic overexpression of the active form of ATF6 promotes hepatic fatty acid oxidation and protects against hepatic steatosis in diet-induced insulin (Montrer INS Kits ELISA)-resistant mice.
The present study extends our understanding and provides new insights into the physiological significance of ATF6, a key signal transducer of ER stress, in ovarian granulosa cells.
ATF6 serves as an important role between ER stress and oxidative stress, by decreasing myocardial ischemia/reperfusion damage.
ATF6alpha mRNA and protein levels were higher in the uterus near the implantation site following embryo implantation.
ATF6a favorably controls chondrogenesis and bone formation (1) by acting as a co-factor of Runx2 (Montrer RUNX2 Kits ELISA) and enhancing Runx2 (Montrer RUNX2 Kits ELISA)-incited hypertrophic chondrocyte differentiation, and (2) by affecting IHH (Montrer IHH Kits ELISA) and PTHrP (Montrer PTHLH Kits ELISA) signaling.
Data show that EIF2AK3/PERK (Montrer EIF2AK3 Kits ELISA)-mediated downregulation of miR (Montrer MLXIP Kits ELISA)-424(322)-503 cluster regulates optimal activation of IRE1 (Montrer ERN1 Kits ELISA) protein and activating transcription factor 6 (ATF6) during conditions of endoplasmic reticulum stress.
Exposure of endothelial cells to VEGF (Montrer VEGFA Kits ELISA), high glucose, or hydrogen peroxide up-regulated the XBP1 (Montrer XBP1 Kits ELISA)/IRE1 alpha (Montrer ERN1 Kits ELISA) and ATF6 arms of the unfolded protein response compared with untreated cells.
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
activating transcription factor 6
, cyclic AMP-dependent transcription factor ATF-6 alpha-like
, cAMP-dependent transcription factor ATF-6 alpha
, cyclic AMP-dependent transcription factor ATF-6 alpha