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Results highlighted the essential roles played by GADD34 (Montrer PPP1R15A Kits ELISA) and CReP in regulating mRNA translation during unstressed conditions and following endoplasmic reticulum stress.
CReP expression was markedly suppressed in XBP1 (Montrer XBP1 Kits ELISA)-deficient mice livers due to hyperactivated Ire1alpha (Montrer ERN1 Kits ELISA).
Ppp1r15a (Montrer PPP1R15A Kits ELISA) mutant mice are superficially indistinguishable from wild type; Ppp1r15b(-/-) mouse embryos survive gestation but exhibit severe growth retardation and impaired erythropoiesis, and loss of both Ppp1r15 genes leads to early embryonic lethality
Whole-exome sequencing identified a homozygous missense mutation, c.1972G>A; p.Arg658Cys, in protein phosphatase 1 (Montrer PPP1CB Kits ELISA), regulatory subunit 15b (PPP1R15B)
the first homozygous mutation in the PPP1R15B gene encoding the regulatory subunit of an eIF2alpha (Montrer EIF2A Kits ELISA)-specific phosphatase in two siblings affected by a novel syndrome of diabetes of youth with short stature, intellectual disability, and microcephaly
CIP2A (Montrer KIAA1524 Kits ELISA) regulates cancer metabolism and CREB (Montrer CREB1 Kits ELISA) phosphorylation in non-small cell lung cancer
the mammalian traffic machinery co-opts p-eIF2alpha (Montrer EIF2A Kits ELISA) and CReP, regulators of translation initiation.
PPP1R15B promotes dephosphorylation of the transcription initiation factor EIF2-alpha (EIF2S1\; MIM 603907) through recruitment of protein phosphatase-1 (PP1) catalytic subunits (see MIM 176875) (Harding et al., 2009
constitutive repressor of eIF2alpha phosphorylation
, protein phosphatase 1 regulatory subunit 15B
, protein phosphatase 1, regulatory (inhibitor) subunit 15B
, protein phosphatase 1, regulatory (inhibitor) subunit 15b