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Aperçu des produits pour anti-LCP2 (LCP2) Anticorps

Full name:
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) Anticorps (LCP2)
Chez www.anticorps-enligne.fr sont 153 Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) Anticorps de 22 de différents fournisseurs disponibles. De plus, nous expédions LCP2 Protéines (9) et LCP2 Kits (4) et beaucoup plus de produits pour cette protéine. Un total de 175 LCP2 produits sont actuellement listés.
Synonymes:
AI323664, BB161688, SLP-76, Slp76, twm

Réactivités les plus populaires pour anti-LCP2 (LCP2) Anticorps

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anti-Mouse (Murine) LCP2 Anticorps:

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anti-LCP2 Anticorps mieux référencés

  1. Human Monoclonal LCP2 Primary Antibody pour IF, IP - ABIN968146 : Harder, Kuhn: Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assemblies. dans The Journal of cell biology 2000 (PubMed)
    Show all 5 references for ABIN968146

  2. Human Monoclonal LCP2 Primary Antibody pour IHC (p), WB - ABIN94466 : Silverman, Shoag, Wu, Koretzky: Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells. dans Molecular and cellular biology 2006 (PubMed)
    Show all 4 references for ABIN94466

  3. Human Monoclonal LCP2 Primary Antibody pour WB - ABIN967597 : Fang, Motto, Ross, Koretzky: Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity. dans Journal of immunology (Baltimore, Md. : 1950) 1996 (PubMed)
    Show all 3 references for ABIN967597

  4. Human Monoclonal LCP2 Primary Antibody pour WB - ABIN967606 : Janssen, Zhang: Adaptor proteins in lymphocyte activation. dans Current opinion in immunology 2003 (PubMed)
    Show all 3 references for ABIN967606

  5. Human Monoclonal LCP2 Primary Antibody pour ICS - ABIN1177173 : Wu, Koretzky: The SLP-76 family of adapter proteins. dans Seminars in immunology 2004 (PubMed)
    Show all 2 references for ABIN1177173

  6. Human Monoclonal LCP2 Primary Antibody pour IP, WB - ABIN264523 : Jackman, Motto, Sun, Tanemoto, Turck, Peltz, Koretzky, Findell: Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. dans The Journal of biological chemistry 1995 (PubMed)
    Show all 2 references for ABIN264523

  7. Human Monoclonal LCP2 Primary Antibody pour IHC (p), IHC - ABIN269168 : Lin, Liu, Moore, Elizer, Veach, Hawiger, Ruley: Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes. dans Journal of immunology (Baltimore, Md. : 1950) 2012 (PubMed)

  8. Human Polyclonal LCP2 Primary Antibody pour IHC, ELISA - ABIN1532089 : Tomomura, Hasegawa, Suda, Sakagami, Tomomura et al.: Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-?B ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling ... dans The Journal of biological chemistry 2012 (PubMed)

Plus d’anticorps contre LCP2 partenaires d’interaction

Mouse (Murine) Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) interaction partners

  1. slp-76 contributes to the regulation of the tissue distribution, PLZF (Montrer ZBTB16 Anticorps), and cytokine expression of iNKT cells via ADAP (Montrer APP Anticorps)-dependent and -independent mechanisms.

  2. findings identify ACK1 (Montrer TNK2 Anticorps) as a novel SLP-76-associated protein-tyrosine kinase (Montrer YES1 Anticorps) that modulates early activation events in T cells.

  3. immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 (Montrer RANGAP1 Anticorps) of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (Montrer NFATC1 Anticorps) and NF-kappaB (Montrer NFKB1 Anticorps) p65 (Montrer NFkBP65 Anticorps) nuclear entry in T cells

  4. these studies establish Slp-76 as a critical determinant of NK-cell development and NK cell mediated elimination of missing-self target cells in mice

  5. Data show that a splice variant of SLP-76 signal transducing adaptor protein (SLP-76 or Lcp2) reduced the amount of SLP-76 protein by ~90%, disrupting immunogenic and tolerogenic pathways to different degrees.

  6. this analysis identified 65 proteins not associated before with the Zap70 (Montrer ZAP70 Anticorps)-Lat (Montrer LAT Anticorps)-SLP-76 network and thus should provide cues for future functional experiments.

  7. A yopH mutant survived better in the absence of neutrophils, indicating that neutrophil inactivation by YopH by targeting PRAM-1 (Montrer PRAM1 Anticorps)/SKAP-HOM (Montrer SKAP2 Anticorps) and SLP-76/Vav (Montrer VAV1 Anticorps)/PLCgamma2 (Montrer PLCG2 Anticorps) signaling hubs may be critical for Yersinia survival.

  8. analysis of a costimulatory mechanism by which CXCL12 (Montrer CXCL12 Anticorps) and antigen converge at SLP-76 microcluster formation to enhance T cell responses

  9. Findings indicate that SLP-76 is an essential signaling component for basophil activation downstream of both FcepsilonRI (Montrer FCER1A Anticorps) and the IL-3 (Montrer IL-3 Anticorps) receptor.

  10. These findings reveal a novel role for SLP-76 in CXCR4 (Montrer CXCR4 Anticorps)-mediated T lymphocyte trafficking.

Human Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) interaction partners

  1. SLP76 is ectopically expressed in chronic lymphocytic leukemia cells where it plays a role in B-cell receptor signaling.

  2. findings identify ACK1 (Montrer TNK2 Anticorps) as a novel SLP-76-associated protein-tyrosine kinase (Montrer EPHA8 Anticorps) that modulates early activation events in T cells.

  3. Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.

  4. TSAD (Montrer SH2D2A Anticorps) binds to and co-localizes with Nck (Montrer NCK1 Anticorps). Expression of TSAD (Montrer SH2D2A Anticorps) increases both Nck (Montrer NCK1 Anticorps)-Lck (Montrer LCK Anticorps) and Nck (Montrer NCK1 Anticorps)-SLP-76 interaction in T cells.

  5. immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 (Montrer RANGAP1 Anticorps) of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (Montrer NFATC1 Anticorps) and NF-kappaB (Montrer NFKB1 Anticorps) p65 (Montrer GORASP1 Anticorps) nuclear entry in T cells

  6. SLP-76 N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor signaling

  7. analysis of a costimulatory mechanism by which CXCL12 (Montrer CXCL12 Anticorps) and antigen converge at SLP-76 microcluster formation to enhance T cell responses

  8. Multipoint binding of SLP-76 to ADAP (Montrer FYB Anticorps) facilitates the assembly of SLP-76 microclusters.

  9. Data indicate a role for the SAM (Montrer TTN Anticorps) domain in mediating SLP-76 self-association for T-cell function.

  10. Data indicate that the intracellular signaling of ITK (Montrer ITK Anticorps)-SYK (Montrer SYK Anticorps) requires both SLP-76 and the adapter function of SYK (Montrer SYK Anticorps)/ZAP-70 (Montrer ZAP70 Anticorps) kinases.

LCP2 profil antigène

Antigen Summary

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

Alternative names and synonyms associated with LCP2

  • lymphocyte cytosolic protein 2 (Lcp2) anticorps
  • lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) (LCP2) anticorps
  • AI323664 anticorps
  • BB161688 anticorps
  • SLP-76 anticorps
  • Slp76 anticorps
  • twm anticorps

Protein level used designations for LCP2

SH2 domain-containing leukocyte protein of 76 kDa , SLP-76 tyrosine phosphoprotein , lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD) , 76 kDa tyrosine phosphoprotein , SH2 domain-containing leukocyte protein of 76kD , lymphocyte cytosolic protein 2 , tyrosine phosphoprotein slp-76

GENE ID SPECIES
16822 Mus musculus
155918 Rattus norvegicus
3937 Homo sapiens
100511843 Sus scrofa
489126 Canis lupus familiaris
513244 Bos taurus
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