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Aperçu des produits pour anti-PTEN (PTEN) Anticorps

Full name:
anti-Phosphatase and Tensin Homolog Anticorps (PTEN)
Chez sont 0 Phosphatase and Tensin Homolog (PTEN) Anticorps de de différents fournisseurs disponibles. Un total de 0 PTEN produits sont actuellement listés.
10q23del, 2310035O07Rik, A130070J02Rik, AI463227, B430203M17Rik, BZS, CWS1, DEC, GLM2, MHAM, Mmac, MMAC1, PTEN1, PTENP1, TEP1
afficher tous les anticorps Gène GeneID UniProt
Anti-Souris PTEN PTEN 19211 O08586
Anti-Rat PTEN PTEN 50557  
Anti-Humain PTEN PTEN 5728 P60484

Afficher tous les synonymes

Plus d’anticorps contre PTEN partenaires d’interaction

Mouse (Murine) Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. Data suggest that reactive oxygen species (ROS (Montrer ROS1 Anticorps))-induced DNA damage results in hypomethylation of the PTEN promoter, upregulation of PTEN mRNA and protein, and a subsequent increase in apoptosis in irradiated lung tissue.

  2. Weight and metformin did not affect the severity of EH resulting from PTEN inactivation

  3. TNF-alpha (Montrer TNF Anticorps) induces vascular insulin (Montrer INS Anticorps) resistance by mechanisms that involve positive modulation of PTEN and inhibition of Akt (Montrer AKT1 Anticorps)/eNOS (Montrer NOS3 Anticorps)/NO signaling.

  4. In summary, our study illustrates the potential signal transduction process of PTEN while stimulated by LPS (Montrer TLR4 Anticorps): by increasing the association of TLR4 (Montrer TLR4 Anticorps), PTEN recruits to its phosphoinositide substrate PI(3,4,5)P3 located on the cell membrane and exerts its dephosphorylated function and subsequently depresses the activity of downstream molecule Akt (Montrer AKT1 Anticorps) and results in activation of NF-kappaB (Montrer NFKB1 Anticorps), followed by the secretion of inflamma...

  5. PTEN is required for stabilization of planar cell packing in the neural plate and for the formation of stable apical-basal microtubule arrays, while PDPK1 (Montrer PDPK1 Anticorps) is required for stabilization of apical junctions during epithelial morphogenesis.

  6. Deletion of PTEN leads to phosphorylation of Serine 133 of Cyclic AMP Response Element-Binding protein, then increases the expression of microRNA-132.

  7. MiR-17-92 functions as a hepatocyte proliferation stimulator and acts in an estrogen-dependent manner. The loss of this miRNA results in increases in p21 (Montrer D4S234E Anticorps) and Pten expression and therefore impairs liver regeneration in female mice.

  8. Analysis of 18 signalling signatures revealed that PI3K signalling is significantly induced whereas EGFR (Montrer EGFR Anticorps) signalling is significantly reduced in Pten() versus PIK3CA (Montrer PIK3CA Anticorps)(H1047R) tumors. Thus, Pten() and PIK3CA (Montrer PIK3CA Anticorps)(H1047R) tumors exhibit discernable differences that may impact tumorigenesis and response to therapy.

  9. These results suggest that the social and anxiety-like phenotypes observed in CNS-specific Pten(-/-) mice may depend on neuronal Pten, as lack of Pten in Fsp1 (Montrer S100A4 Anticorps)-expressing cells of the CNS had little effect on these behaviors.

  10. These findings demonstrate that melatonin attenuates cisplatin-induced follicle loss by preventing the phosphorylation of PTEN/AKT (Montrer AKT1 Anticorps)/FOXO3a (Montrer FOXO3 Anticorps) pathway members; thus, melatonin is a potential therapeutic agent for ovarian protection and fertility preservation during chemotherapy in female cancer patients.

Human Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. Data suggest that microRNA-92b up-regulates cell proliferation/cell migration/tumor invasiveness and down-regulates apoptosis of glioma cells via PTEN/AKT (Montrer AKT1 Anticorps) (phosphatase and tensin homolog protein/protein kinase b alpha (Montrer AKT1 Anticorps)) signaling pathway.

  2. Inhibition of protooncogenic microRNA-181a may suppress proliferation and invasion and promote apoptosis of cervical cancer cells through the PTEN/Akt (Montrer AKT1 Anticorps)/FOXO1 (Montrer FOXO1 Anticorps) pathway.

  3. miR (Montrer MLXIP Anticorps)-106a promoted the growth and invasion of SKOV3 cells by targeting phosphatase and tensin homolog (PTEN). Furthermore, the present study revealed that IL-6 (Montrer IL6 Anticorps) inhibited miR (Montrer MLXIP Anticorps)-106a expression by activating STAT3 (Montrer STAT3 Anticorps). Tocilizumab, a humanized anti-human IL-6R antibody, that competitively inhibits IL-6 (Montrer IL6 Anticorps)/IL-6R signaling, did not inhibit the proliferation and invasion of SKOV3 cells.

  4. miR (Montrer MLXIP Anticorps)-101 could bind 3'-UTR (Montrer UTS2R Anticorps) of WT-PTEN with reduced fluorescent intensity, suggesting that PTEN was the target gene. SMMC-7721, HepG2 and Huh7 were eligible cell lines for miR (Montrer MLXIP Anticorps)-101 studies. miR (Montrer MLXIP Anticorps)-101 was an applicable molecular marker of HCC (Montrer FAM126A Anticorps)

  5. Reduced PTEN expression may be an indicator for poor prognosis in patients with lung cancer. The presence of PTEN expression may define a subset of patients with lung cancer appropriate for investigational therapeutic strategies

  6. High expression of PTEN is associated with Adriamycin resistance in breast cancer.

  7. PTEN and PIK3CA (Montrer PIK3CA Anticorps) were shown to be upregulated by 89 and 76% (western blot), respectively, in the pemetrexed-resistant cell line compared with control cells.

  8. Data suggest that reactive oxygen species (ROS (Montrer ROS1 Anticorps))-induced DNA damage results in hypomethylation of the PTEN promoter, upregulation of PTEN mRNA and protein, and a subsequent increase in apoptosis in irradiated lung tissue.

  9. PTEN is a direct functional target of miR (Montrer MLXIP Anticorps)-130b. In hepatocellular carcinoma, miR (Montrer MLXIP Anticorps)-130b may promote proliferation and EMT (Montrer ITK Anticorps)-induced metastasis via PTEN/p-AKT (Montrer AKT1 Anticorps)/HIF-1alpha (Montrer HIF1A Anticorps) signaling.

  10. These data demonstrated that PTEN upregulation could reduce invasion by inhibiting the process of EMT (Montrer ITK Anticorps) in Tca8113 cells, which might be related to the Hedgehog (Montrer SHH Anticorps) signaling pathway.

Pig (Porcine) Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. PTEN, FOXO3A (Montrer FOXO3 Anticorps) and PKB (Montrer AKT1 Anticorps) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.

Cow (Bovine) Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. miR (Montrer MYLIP Anticorps)-26b participates in the inflammatory response of LPS (Montrer IRF6 Anticorps)-stimulated bAMs by modulating the NF-kappaB (Montrer NFKB1 Anticorps) pathway through targeting PTEN.

  2. Pten expression levels in the mammary glands of dairy cows, was investigated.

  3. These studies identify a key role for PTEN in the modulation of lipid mediators involved in adenosine diphosphate receptor-regulated endothelial signaling pathways involving eNOS (Montrer NOS3 Anticorps) activation in vascular endothelial cells.

  4. Overexpressing PTEN enhanced fatty acid oxidation and assembly and secretion of VLDL in cultured hepatocytes.

  5. Inhibition of PTEN activity had no effect on cyclic strain-mediated cell proliferation but inhibited cyclic strain-mediated suppression of apoptosis

Xenopus laevis Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. PTEN plays an important role in multicilia formation and cilia disassembly by controlling the phosphorylation of Dishevelled (Montrer DVL2 Anticorps).

  2. PTEN negatively regulates growth cone phosphatidylinositol 3,4,5-trisphosphate levels and mediates chemorepulsion, whereas chemoattraction is PTEN-independent.

  3. PTEN-dependent slowing of axonal growth enables the establishment of stable nerve-muscle contacts that develop into neuromuscular junctions.

PTEN profil antigène

Antigen Summary

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT\\/PKB signaling pathway.

Alternative names and synonyms associated with PTEN

  • phosphatase and tensin homolog (Pten) anticorps
  • phosphatase and tensin homolog (PTEN) anticorps
  • phosphatase and tensin homolog (pten) anticorps
  • 10q23del anticorps
  • 2310035O07Rik anticorps
  • A130070J02Rik anticorps
  • AI463227 anticorps
  • B430203M17Rik anticorps
  • BZS anticorps
  • CWS1 anticorps
  • DEC anticorps
  • GLM2 anticorps
  • MHAM anticorps
  • Mmac anticorps
  • MMAC1 anticorps
  • PTEN1 anticorps
  • PTENP1 anticorps
  • TEP1 anticorps

Protein level used designations for PTEN

mutated in multiple advanced cancers 1 , phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN , phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN , protein tyrosine phosphatase and tensin-like protein , phosphatase and tensin homolog deleted on chromosome ten , phosphatase and tensin homolog (mutated in multiple advanced cancers 1) , MMAC1 phosphatase and tensin homolog deleted on chromosome 10 , phosphatase and tensin-like protein , homolog of human mutated in multiple advanced cancers , protein/lipid phosphatase Pten

19211 Mus musculus
50557 Rattus norvegicus
423675 Gallus gallus
5728 Homo sapiens
403832 Canis lupus familiaris
100156264 Sus scrofa
540786 Bos taurus
399142 Xenopus laevis
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