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genetic analyses of indel loci in ACE (Montrer ACE Kits ELISA), DJ-1 (Montrer PARK7 Kits ELISA), and GIGYF2 genes, was performed to explore the potential contribution of insertion (I)/deletion (D) polymorphisms (indels) to the risk of PD in a Chinese population.
Full-length GIGYF2 coimmunoprecipitates with AGO2 (Montrer EIF2C2 Kits ELISA) in human cells, and upon tethering to a reporter mRNA, GIGYF2 exhibits strong, dose-dependent silencing activity, involving both mRNA destabilization and translational repression.
required, this finding may shed light on the GIGYF2-associated mechanisms that lead to PD and suggests insulin (Montrer INS Kits ELISA) dysregulation as a disease-specific mechanism for both PD and cognitive dysfunction.
Results suggest that the N56S and N457T of GIGYF2 are risk factors for Parkinson's disease in Caucasians, but not in Asians
GIGYF2 and the zinc finger protein 598 (ZNF598) are identifie (Montrer EIF4E Kits ELISA)d as components of the 4EHP complex.
Our result indicated that SCNA, LRRK2 (Montrer LRRK2 Kits ELISA), UCHL1 (Montrer UCHL1 Kits ELISA), HtrA2 (Montrer HTRA2 Kits ELISA) and GIGYF2 genes' mutations might not be a main reason for Chinese Autosomal dorminant Parkinson's disease
within the Chinese population, the c.297T>C p.Ala99Ala polymorphism of the GIGYF2 gene may be associated with an increased risk of developing Parkinson disease.
These data, together with those recently reported by other groups, suggest that GIGYF2 is unlikely to be the PARK11 gene.
No clearly pathogenic mutations are identified in GIGYF2 and ATP13A2 (Montrer ATP13A2 Kits ELISA) in Brazilian patients with early-onset Parkinson's disease.
The results of this study did not support a role for GIGYF2 in the genetic etiology of Belgian Parkinson disease.
Negative regulation of Grb10 (Montrer GRB10 Kits ELISA) Interacting GIGYF2 protein on IGF-1 (Montrer IGF1 Kits ELISA) receptor signaling pathway caused diabetic mice cognitive impairment.
Disruption of the eukaryotic translation initiation factor 4E (Montrer EIF4E Kits ELISA) - Gigyf2 complex leads to increased translation and perinatal lethality in mice.
Primary cultured embryo fibroblasts from Gigyf2 null mice exhibit decreased IGF1 (Montrer IGF1 Kits ELISA) signaling.
identification of proteins linked to insulin (Montrer INS Kits ELISA)-like growth factor (IGF-I (Montrer IGF1 Kits ELISA)) receptors by the Grb10 (Montrer GRB10 Kits ELISA) adapter and modulate IGF-I (Montrer IGF1 Kits ELISA) signaling
The protein encoded by this gene interacts with GRB10 and may be involved in the regulation of tyrosine kinase receptor signaling. This gene contains CAG repeats, and the encoded protein contains stretches glutamine and glutamic acid residues. Defects in this gene are a cause of Parkinson disease type 11 (PARK11). Multiple transcript variants encoding several different isoforms have been found for this gene.
trinucleotide repeat containing 15
, GRB10 interacting GYF protein 2
, PERQ amino acid-rich with GYF domain-containing protein 2
, PERQ amino acid rich, with GYF domain 3
, Parkinson disease (autosomal recessive, early onset) 11
, trinucleotide repeat-containing gene 15 protein
, GRB10-interacting GYF protein 2