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Gnai1 function is impaired in the spinal cord of Ews/Ewsr1 (Montrer EWSR1 Kits ELISA) KO mice
LGN (Montrer GPSM2 Kits ELISA) and Galphai participate in a long-inferred signal that originates outside the bundle to model its staircase-like architecture, a property that is essential for direction sensitivity to mechanical deflection and hearing.
stimulation of GPR17 (Montrer GPR17 Kits ELISA) by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein (Montrer MBP Kits ELISA) expression levels mainly by triggering the Galphai/o signaling pathway.
Gnai1 missense mutation is responsible of hyperpigmentation in mouse model.
acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors.
Data show that guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Galphai1/3) can interact with CD14 antigen/Grb2-associated binding protein Gab1, which modulates macrophage polarization in vitro and in vivo.
By using mice deficient in individual Galphai/o G-protein subunits, authors demonstrate that Galphai1 and Galphai3 are the critical in vivo targets of ADP-ribosylation underlying vasoactive amine sensitization elicited by pertussis toxin exposure.
leucine can directly facilitate insulin (Montrer INS Kits ELISA) signaling through a Galphai protein-dependent intracellular signaling pathway
Inactive Galpha(i1)-GDP enhances the affinity of RGS14 for H-Ras-GTP in live cells, resulting in a ternary signaling complex that is further regulated by G protein-coupled receptors.
Mice with mutations of Gnai1 or Gnai2 (Montrer GNAI2 Kits ELISA) have neither fusions of ribs nor lumbar vertebrae, but loss of both Gnai3 (Montrer GNAI3 Kits ELISA) and one of the other two genes increases the number and severity of rib fusions without affecting the lumbar fusions.
These data indicate that, unlike in taste cells, TAS2Rs couple to the prevalent G proteins, Galphai1, Galphai2 (Montrer GNAI2 Kits ELISA), and Galphai3 (Montrer GNAI3 Kits ELISA), with no evidence for functional coupling to Galphagust.
testosterone rapidly increased whole-cell HCAEC SKCa and BKCa (Montrer KCNMA1 Kits ELISA) currents via a surface androgen receptor (Montrer AR Kits ELISA), Gi/o protein, and protein kinase A
These findings suggest that Gi1 interacts only with active GPCRs and that the well known high speed of GPCR signal transduction does not require preassembly between G proteins and GPCRs.
CGRP (Montrer S100A12 Kits ELISA) family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas (Montrer GNAS Kits ELISA), Galphai, and Galphaq (Montrer GNAQ Kits ELISA)/11 pathways.
biochemical and computational data indicate that the interactions between alpha5, alpha1, and beta2-beta3 are not only vital for GDP release during G protein activation, but they are also necessary for proper GTP binding (Montrer RND2 Kits ELISA) (or GDP rebinding).
Data indicate that hydroxyurea (HU) induces SAR1 (Montrer IQGAP1 Kits ELISA) protein expression, which in turn activates gamma-globin (Montrer HBG1 Kits ELISA) expression, predominantly through the Gialpha/JNK (Montrer MAPK8 Kits ELISA)/Jun (Montrer JUN Kits ELISA) pathway.
Gi alpha subunit (Montrer POLG Kits ELISA) was found to be a key modulator of GABAB-receptors signaling in analgesia.
AC5, by binding active Galphai1, interferes with G-protein deactivation and reassembly and thereby might sensitize its own regulation.
Data indicate that focal adhesion kinase (FAK) activation and cell migration require Src, Gi/Go, COX-2 and LOXs activities.
resistin (Montrer RETN Kits ELISA) contributes to the pro-inflammatory state of SMC (Montrer DYM Kits ELISA) by the up-regulation of CX3CL1 (Montrer CX3CL1 Kits ELISA) and CX3CR1 (Montrer CX3CR1 Kits ELISA) expression via a mechanism involving NF-kB, AP-1 (Montrer FOSB Kits ELISA), and STAT1 (Montrer STAT1 Kits ELISA)/3 transcription factors, (2) resistin (Montrer RETN Kits ELISA) employs TLR4 (Montrer TLR4 Kits ELISA) and Gi-protein signaling.
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene.
adenylate cyclase-inhibiting G alpha protein
, guanine nucleotide binding protein, alpha inhibiting 1
, guanine nucleotide-binding protein G(i) subunit alpha-1
, Gi1 protein alpha-subunit
, alpha-subunit of G-protein, type G-alpha-i-1
, guanine nucleotide-binding protein G(i), alpha-1 subunit
, Gi1 protein alpha subunit
, Gi-alpha-1 protein
, guanine nucleotide binding protein (G protein), alpha inhibiting 1
, Galpha i1a