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anti-Human TGFBR1 Anticorps:
anti-Rat (Rattus) TGFBR1 Anticorps:
anti-Mouse (Murine) TGFBR1 Anticorps:
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Human Polyclonal TGFBR1 Primary Antibody pour IF (p), IHC (p) - ABIN671256
Xie, Chen, Miao, Tang, Fu: Regulation of cellular behaviors of fibroblasts related to wound healing by sol-gel derived bioactive glass particles. dans Journal of biomedical materials research. Part A 2016
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Human Polyclonal TGFBR1 Primary Antibody pour IHC (p), WB - ABIN392279
Miles, Tung, Aguiar, Kurtoglu, Sikes: Increased TGF-?1-mediated suppression of growth and motility in castrate-resistant prostate cancer cells is consistent with Smad2/3 signaling. dans The Prostate 2012
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Human Polyclonal TGFBR1 Primary Antibody pour IF, WB - ABIN317892
Yu, Hu, Yang, Takemori, Li, Zheng, Hong, Liao, Wen: Salt-inducible kinase 1 is involved in high glucose-induced mesangial cell proliferation mediated by the ALK5 signaling pathway. dans International journal of molecular medicine 2013
Mouse (Murine) Monoclonal TGFBR1 Primary Antibody pour FACS - ABIN4896300
Bodogai, Moritoh, Lee-Chang, Hollander, Sherman-Baust, Wersto, Araki, Miyoshi, Yang, Trinchieri, Biragyn: Immunosuppressive and Prometastatic Functions of Myeloid-Derived Suppressive Cells Rely upon Education from Tumor-Associated B Cells. dans Cancer research 2015
Human Polyclonal TGFBR1 Primary Antibody pour ELISA, WB - ABIN563176
Matsunobu, Torigoe, Ishikawa, de Vega, Kulkarni, Iwamoto, Yamada: Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. dans Developmental biology 2009
combined inhibition of ALK5 and CTGF (Montrer CTGF Anticorps) is required to prevent TGFbeta (Montrer TGFB1 Anticorps)-induced nodule formation in tri (Montrer VANGL2 Anticorps)-cellular cultures
Aortic diseases in patients with TGFBR1 or TGFBR2 (Montrer TGFBR2 Anticorps) mutations show the same prevalence of systemic features and the same global survival.
Results show that TGFBR1 expression is regulated in bladder cancer cell through its desumoylation by SENP2.
Low TGFBR1 expression is associated with oral cancer progression.
TGF-beta (Montrer TGFB1 Anticorps) type I, II, and III receptors were all identified in pregnant serum; all were substantially elevated in early-onset but not late-onset preeclampsia. Endoglin (Montrer ENG Anticorps) was increased in both subtypes.
Overexpression of truncated ALK5 in a B-cell line counteracted BMP-7 (Montrer BMP7 Anticorps)-induced apoptosis, whereas overexpression of truncated ALK4 (Montrer ACVR1B Anticorps) had no effect.
Although TGFbeta1 (Montrer TGFB1 Anticorps)/2 receptors are downregulated in breast cancer, their expression in tumors is an indicator of aggressive breast cancer phenotype.
Higher proportions of early-onset Diffuse Gastric Cancers (DGCs) contained somatic mutations in CDH1 (Montrer CDH1 Anticorps) or TGFBR1 compared with late-onset DGCs. A smaller proportion of early-onset DGCs contained somatic mutations in RHOA (Montrer RHOA Anticorps). CDH1 (Montrer CDH1 Anticorps) alterations, but not RHOA (Montrer RHOA Anticorps) mutations, were associated with shorter survival times. Female predominance in early-onset DGC (Montrer GGCX Anticorps) may be related to relatively high rates of somatic CDH1 (Montrer CDH1 Anticorps) and TGFBR1 mutations.
Coronin 1B (Montrer CORO1B Anticorps) constitutively binds to TGF beta (Montrer TGFB1 Anticorps) receptor I in vascular smooth muscle cells.
BIX02189 is a potent inhibitor of TGF-beta type I receptor that can block the lung tumor metastatic activity of TGF-beta1 (Montrer TGFB1 Anticorps).
The results indicate that the TGFBR1 gene polymorphism (SNP64) is significantly associated with growth rates including average daily gains between birth and 56 kg, between 5.5 and 56 kg, between 35 and 56 kg.
Report temporal regulation of TGFBR1 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
TGFbeta (Montrer TGFB1 Anticorps) is abundant in boar seminal plasma, thus TGFbeta (Montrer TGFB1 Anticorps) may be a male-female signalling agent involved in immune changes in the female reproductive tract elicited by seminal fluid.
Porcine transforming growth factor beta receptor 1 has many polymorphisms, including two nonsynonymous substitutions in exons 1 and 7 and novel alternative splicing in exon 3.
isolation and molecular characterization; the full-length TGFBR1 cDNA 1813 bp contains an open reading frame (ORF) of 1512 bp encoding a TGFBR1 protein of 503 amino acids with a calculated molecular weight of 56.4 kDa.
Results show that ALK5 and ALK1 (Montrer ACVRL1 Anticorps) play antagonistic roles in TGF-beta (Montrer TGFB1 Anticorps)-induced podosome formation in aortic endothelial cells.
This study showed that ubiquitinated ALK5 and phosphorylated heat shock protein 27 specifically accumulate in the cytoskeleton fraction, and ALK1 (Montrer ACVRL1 Anticorps) and ALK5 interact with heat shock protein 90 (Montrer HSP90 Anticorps).
GM-CSF (Montrer CSF2 Anticorps) induced airway smooth muscle cells to increase expression of transforming growth factor (TGF)-beta (Montrer TGFB1 Anticorps) receptors type I, II, and III, but had no detectable effect on the release of TGF-beta1 (Montrer TGFB1 Anticorps) by the same ASMC; corticosteroids were inhibitory
ALK5 and Smad4 (Montrer SMAD4 Anticorps) have roles in TGF-beta1 (Montrer TGFB1 Anticorps)-induced pulmonary endothelial permeability
These results indicate that high plasma cholesterol levels may contribute to the pathogenesis of certain diseases (e.g., atherosclerosis) by suppressing TGF-beta (Montrer TGFB1 Anticorps) responsiveness.
Transforming growth factor-beta1 protects against pulmonary artery endothelial cell apoptosis via ALK5.
ALK1 and ALK5 are both essential for correct regulation of VEGF, and that disruption of either pathway leads to disease.
TGF-beta1 (Montrer TGFB1 Anticorps) downregulates caveolin-1 (Montrer CAV1 Anticorps) of cultured endothelial cells, involving ALK-5 receptor subtype
Conditional deletion of Tgfbr1 in PTEN (Montrer PTEN Anticorps)-inactivated endometrium leads to a disease that recapitulates invasive and lethal human endometrial cancer.
fluid shear stress induces autocrine TGF-beta (Montrer TGFB1 Anticorps)/ALK5-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1 (Montrer MAP2K1 Anticorps)/2-mediated signaling.
both GDF-15 (Montrer GDF15 Anticorps) and TGF-beta1 (Montrer TGFB1 Anticorps) counteract chemokine (Montrer CCL1 Anticorps)-induced integrin activation on neutrophils via the ALK-5/TGF-betaRII heterodimer.
CD109 (Montrer CD109 Anticorps) differentially regulates TGF-beta (Montrer TGFB1 Anticorps)-induced ALK1 (Montrer ACVRL1 Anticorps)-Smad1 (Montrer SMAD1 Anticorps)/5 versus ALK5-Smad2 (Montrer SMAD2 Anticorps)/3 pathways, leading to decreased extracellular matrix production in the skin; epidermal CD109 (Montrer CD109 Anticorps) expression regulates dermal function through a paracrine mechanism
miR (Montrer MLXIP Anticorps)-27b is an anti-fibrotic microRNA that inhibits fibroblast activation by targeting TGFbeta (Montrer TGFB1 Anticorps) receptor 1 and SMAD2 (Montrer SMAD2 Anticorps).
In the presence of gadolinium and antibeta1 integrin antibody, collagen regulated the expression levels of Tgfbr1, Tgfbr2 (Montrer TGFBR2 Anticorps) and Smad2 (Montrer SMAD2 Anticorps)/3, but did not alter the phosphorylation of p38 (Montrer CRK Anticorps), ERK1/2 (Montrer MAPK1/3 Anticorps) or JNK (Montrer MAPK8 Anticorps).
miR (Montrer MLXIP Anticorps)-22 acts as a novel negative regulator of angiotensin II-induced cardiac fibrosis by suppressing the expression of TGFbetaRI in the heart.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin (Montrer BIRC5 Anticorps) and inhibit Wnt (Montrer WNT2 Anticorps) in CPCs to mediate cardioprotection and improve cardiac function.
Data show that transforming growth factor-beta receptor I (Tgfbr1) was a direct target of microRNA miR (Montrer MLXIP Anticorps)-140-5p.
Targeted early inactivation of Alk5 in mesodermal progenitors caused abnormal development and maturation of the lung that included reduced physical size of the sub-mesothelial mesoderm, an established source of specific mesodermal progenitors.
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
TGF-beta receptor type-1
, type I serine/threonine kinase receptor
, transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)
, transforming growth factor beta type I receptor
, transforming growth factor, beta receptor 1 (activin A receptor type II-like kinase, 53kDa)
, transforming growth factor, beta receptor 1
, transforming growth factor beta receptor 1
, TGF-beta receptor type-1-like
, TGF-beta receptor type I
, TGF-beta type I receptor
, activin A receptor type II-like kinase, 53kD
, activin A receptor type II-like kinase, 53kDa
, activin A receptor type II-like protein kinase of 53kD
, activin receptor-like kinase 5
, serine/threonine-protein kinase receptor R4
, transforming growth factor beta receptor I
, transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD)
, transforming growth factor-beta receptor type I
, transforming growth factor, beta receptor I
, activin A receptor type II-like kinase
, transforming growth factor beta receptor type I
, transforming growth factor beta, receptor 1