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anti-Human FOXA1 Anticorps:
anti-Mouse (Murine) FOXA1 Anticorps:
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Human Monoclonal FOXA1 Primary Antibody pour IHC (p), RNAi - ABIN561299
Bretschneider, Brand, Miller, Lowery, Kerin, Gannon, Denger: Estrogen induces repression of the breast cancer and salivary gland expression gene in an estrogen receptor alpha-dependent manner. dans Cancer research 2008
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Human Monoclonal FOXA1 Primary Antibody pour ChIPSeq, ChIP - ABIN2668682
Nucera, Eeckhoute, Finn, Carroll, Ligon, Priolo, Fadda, Toner, Sheils, Attard, Pontecorvi, Nose, Loda, Brown: FOXA1 is a potential oncogene in anaplastic thyroid carcinoma. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2009
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Cow (Bovine) Polyclonal FOXA1 Primary Antibody pour WB - ABIN2780597
Lupien, Eeckhoute, Meyer, Wang, Zhang, Li, Carroll, Liu, Brown: FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. dans Cell 2008
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Human Polyclonal FOXA1 Primary Antibody pour ChIP, IHC (p) - ABIN249930
Lin, Miller, Contreras, Prescott, Dagenais, Wu, Yee, Orringer, Misek, Hanash, Glover, Beer: The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas. dans Cancer research 2002
Findings suggested FOXA1 may act as an anti-oncogene (Montrer RAB1A Anticorps) in gastric cancer (GC) cells. Low-level expression of FOXA1 protein was confirmed in GC tissues and cell lines. FOXA1 over-expression could significantly affect cell proliferation, apoptosis and tumor invasion of GC cells, which may be resulted by reversing EMT (Montrer ITK Anticorps).
High expression of FOXA1 is an independent prognostic parameter in ERG (Montrer ERG Anticorps) negative prostate cancer
A molecular mechanism by which Estradiol antagonizes GR-dependent induction of specific genes by preventing the recruitment of the pioneer factors FOXA1 and FOXA2 (Montrer FOXA2 Anticorps) in a physiologically relevant model.
Results show that c-Abl (Montrer ABL1 Anticorps) phosphorylates FoxA1 at multiple sites. Tyr429 and Tyr464 were identified as the major phosphorylation sites in the FoxA1 C-terminal region. This c-Abl (Montrer ABL1 Anticorps)-mediated phosphorylation of FoxA1 promotes the activation of estrogen signaling by inducing its binding to histones.
MLL3 binding was dependent on FOXA1, indicating that FOXA1 recruits MLL3 to chromatin. MLL3 silencing decreased H3K4me1 at enhancer elements but had no appreciable impact on H3K4me3 at enhancer elements. We propose a mechanism whereby the pioneer factor FOXA1 recruits the chromatin modifier MLL3 to facilitate the deposition of H3K4me1 histone marks, subsequently demarcating active enhancer elements
FoxA1 discriminates between medullary thyroid carcinoma and tumors of follicular derivation with sensitivity and specificity greater than calcitonin (Montrer CALCA Anticorps) and carcinoembryonic antigen (Montrer CEACAM5 Anticorps).
FOXA1 loss may play a significant role in enabling prostate cancer progression to neuroendocrine prostate cancer, whereas IL-8 (Montrer IL8 Anticorps) and MAPK/ERK (Montrer MAPK1 Anticorps) pathways may be promising targets for therapeutic intervention.
Low FOXA1 expression is associated with breast cancer invasion and metastasis.
the distinct mechanisms by which GATA2 (Montrer GATA2 Anticorps) and FOXA1 regulate AR cistrome and suggest that FOXA1 acts upstream of GATA2 (Montrer GATA2 Anticorps) and AR in determining hormone-dependent gene expression in prostate cancer.
Study implicates enhancer reprogramming, FOXA1 upregulation, and a retrograde developmental transition in pancreatic ductal adenocarcinoma metastasis.
this model system will facilitate further in vivo functional studies of Foxa1 or other factors in mammary gland development and tumor formation and progression
Loss of Interdependent Binding by the FoxO1 (Montrer FOXO1 Anticorps) and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin (Montrer INS Anticorps)-sensitive Genes.
FoxA1, FoxA2 (Montrer FOXA2 Anticorps), and LIPG (Montrer LIPG Anticorps) control the uptake of extracellular lipids for breast cancer growth.
genome-wide binding sites of the forkhead/winged helix transcription factor (Montrer FOXP2 Anticorps) Foxa1, which functions redundantly with Foxa2 (Montrer FOXA2 Anticorps) to regulate the differentiation of midbrain dopamine neurons, were characterized.
Disruption of Shp (Montrer LAMC1 Anticorps) in mice alters timing of expression of genes that regulate homocysteine metabolism and the liver responses to ethanol and homocysteine. SHP (Montrer LAMC1 Anticorps) inhibits the transcriptional activation of Bhmt (Montrer BHMT Anticorps) and cystathionine gamma-lyase (Montrer CTH Anticorps) by FOXA1.
ChIP-exonuclease of the ER pioneer factor FoxA1 identifies protected DNA with a predictable 8 bp overhang from the Forkhead motif, which authors term mesas; showed that mesas occur in multiple cellular contexts and exist as single or overlapping motifs.
TIP30 (Montrer HTATIP2 Anticorps) is a key regulator for maintaining ER(+) and ER(-)luminal pools in the mammary luminal lineage via FoxA1.
Mechanistically, JARID1B (Montrer KDM5B Anticorps) was required for GATA3 (Montrer GATA3 Anticorps) recruitment to the Foxa1 promoter to activate Foxa1 expression.
Foxa1 recruited Grg3 to the Nanog (Montrer NANOG Anticorps) promoter -2kb upstream region and switched the promoter to an inactive chromatin status represented by typical modifications in histone H3 (Montrer HIST3H3 Anticorps).
Results indicate Foxa1 expression is required for the maintenance of prostatic cellular differentiation.
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
forkhead box A1
, forkhead box protein A4
, HNF-3 alpha
, HNF3 alpha
, forkhead box protein A1
, forkhead transcription factor FoxA1
, forkhead homolog
, hepatocyte nuclear factor 3-alpha-like
, fork head domain protein 7
, hepatocyte nuclear factor 3-alpha
, HNF3alpha homolog B
, fork head domain-related protein 7'
, forkhead box protein A1-B
, forkhead protein 2
, hepatocyte nuclear factor 3-alpha homolog B
, transcription factor 3A
, hepatocyte nuclear factor 3 alpha
, fork head domain
, hepatocyte nuclear factor 3 alpha (winged helix transcription factor)
, hepatocyte nuclear factor 3, alpha