Aperçu des produits pour KDM3A Protéines (KDM3A)

Full name:
Lysine (K)-Specific Demethylase 3A Protéines (KDM3A)
Chez www.anticorps-enligne.fr sont 5 Lysine (K)-Specific Demethylase 3A (KDM3A) Protéines de 3 de différents fournisseurs disponibles. De plus, nous expédions KDM3A Anticorps (140) et beaucoup plus de produits pour cette protéine. Un total de 151 KDM3A produits sont actuellement listés.
Synonymes:
1700105C21Rik, C230043E16Rik, JHDM2a, JHMD2A, Jmjd1, Jmjd1a, KDM2A, kdm3a, mKIAA0742, TGSA, Tsga
afficher tous les protéines Gène GeneID UniProt
Rat KDM3A KDM3A 682469  
KDM3A 55818 Q9Y4C1
KDM3A 104263 Q6PCM1

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KDM3A Protéines (KDM3A) par origine

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Plus protéines pour KDM3A partenaires d'interaction

Human Lysine (K)-Specific Demethylase 3A (KDM3A) interaction partners

  1. Authors show that KDM3A regulates MCAM (Montrer MCAM Protéines) expression both through a direct mechanism, involving modulation of H3K9 methylation at the MCAM (Montrer MCAM Protéines) promoter, and an indirect mechanism, via the Ets1 (Montrer ETS1 Protéines) transcription factor.

  2. JMJD1A promotes urinary bladder cancer progression by enhancing glycolysis through coactivation of HIF1alpha (Montrer HIF1A Protéines).

  3. depletion of KDM3A was capable of reactivating mutated p53 (Montrer TP53 Protéines) to induce the expression of pro-apoptotic genes in breast cancer with mutant p53 (Montrer TP53 Protéines). KDM3A knockdown also potently inhibited tumorigenic potentials of breast cancer stem-like cells and rendered them sensitive to apoptosis induced by chemotherapeutic drugs.

  4. our findings reveal a novel mechanism by which KDM3A promotes ovarian CSCs, proliferation and chemoresistance and thus, highlights the significance of KDM3A as a novel therapeutic target for resistant ovarian cancer.

  5. a critical role for JMJD1A in regulating proliferation and survival of prostate cancer cells by controlling c-Myc (Montrer MYC Protéines) expression at transcriptional and post-translational levels

  6. deficient expression of JMJD1A/JMJD1A might be reflecting and/or contributing to round spermatid maturation arrest

  7. JMJD1A could promote non-small cell lung cancer tumorigenesis

  8. Study identified KDM3A an H3K9me2 demethylase (Montrer MBD2 Protéines), as responsible for the H3K9me2 reduction and critical for breast tumor transformation.

  9. JMJD1A-MALAT1-MAPK (Montrer MAPK1 Protéines) signaling might participate in the JMJD1A-induced cell proliferation of gastric cancer.

  10. These results indicate that the KDM3A-KLF2 (Montrer KLF2 Protéines)-IRF4 (Montrer IRF4 Protéines) pathway plays an essential role in multiple myeloma cell survival and homing to the bone marrow, and therefore represents a therapeutic target.

Cow (Bovine) Lysine (K)-Specific Demethylase 3A (KDM3A) interaction partners

  1. Histone demethylases KDM3A, KDM4A (Montrer KDM4A Protéines), and KDM4C (Montrer KDM4C Protéines) were expressed before and after embryonic genome activation, whereas KDM5B (Montrer KDM5B Protéines) was mainly expressed during the blastocyst period.

Mouse (Murine) Lysine (K)-Specific Demethylase 3A (KDM3A) interaction partners

  1. JMJD1A is phosphorylated at S265 by protein kinase A (PKA), and this is pivotal to activate the beta1-adrenergic receptor gene (Adrb1 (Montrer ADRB1 Protéines)) and downstream targets including Ucp1 (Montrer UCP1 Protéines) in brown adipocytes.

  2. Kdm3a localizes to cytoplasmic structures of maturing spermatids affected in Kdm3a mutant mice, which in turn display altered fractionation of beta-actin (Montrer ACTB Protéines) and gamma-tubulin (Montrer TUBG1 Protéines).

  3. Results show that Jmjd1a was not essential for stem cell self-renewal but played a crucial role as a tumor suppressor.

  4. Despite these differences in rats, genetic knockout of Kdm3a in mice resulted in no dramatic effect on immune system development and activation or EAE susceptibility and severity

  5. Jmjd1a directly and positively controls Sry (Montrer SRY Protéines) expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination.

  6. Exposing cells to either chemical or cellular sources of (*)NO resulted in a significant increase in dimethyl Lys (Montrer LYZ Protéines)-9 on histone 3 (H3K9me2), the preferred substrate for KDM3A.

  7. the Jmjd1a-controlled epigenetic histone modifications are crucial for Crem (Montrer CREM Protéines)-regulated gene expression and spermatogenesis

  8. TSGA may modulate the function of ER71 (Montrer ETV2 Protéines) and thereby affect spermatogenesis as well as embryonic development

  9. Jmjd1a might be a critical signaling molecule underlying the maintenance of pluripotency in mouse embryonic stem cells

  10. Jmjd1a demethylates H3K9Me2 at the promoter regions of Tcl1, Tcfcp2l1, and Zfp57 and positively regulates the expression of these pluripotency-associated genes.

Profil protéine KDM3A

Profil protéine

This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with KDM3A

  • lysine (K)-specific demethylase 3B (Kdm3b)
  • lysine (K)-specific demethylase 3A (kdm3a)
  • lysine (K)-specific demethylase 3A (KDM3A)
  • jumonji domain containing 1A (LOC100224407)
  • jumonji domain containing 1A (LOC100226356)
  • lysine (K)-specific demethylase 3A (kdm3a-b)
  • lysine (K)-specific demethylase 3A (Kdm3a)
  • 1700105C21Rik Protéine
  • C230043E16Rik Protéine
  • JHDM2a Protéine
  • JHMD2A Protéine
  • Jmjd1 Protéine
  • Jmjd1a Protéine
  • KDM2A Protéine
  • kdm3a Protéine
  • mKIAA0742 Protéine
  • TGSA Protéine
  • Tsga Protéine

Protein level used designations for KDM3A

lysine (K)-specific demethylase 3A , jumonji domain containing 1A , lysine-specific demethylase 3A-like , jmjC domain-containing histone demethylation protein 2A , jumonji domain-containing protein 1A-B , lysine-specific demethylase 3A-B , jumonji domain-containing protein 1A , lysine-specific demethylase 3A , jumonji C domain-containing histone demethylase 2A , jumonji domain containing 1 , testis-specific protein A , testis specific gene A , probable zinc finger protein , testis-specific gene A protein , zinc finger protein TSGA

GENE ID SPECIES
682469 Rattus norvegicus
100379807 Xenopus (Silurana) tropicalis
470424 Pan troglodytes
697775 Macaca mulatta
100224407 Taeniopygia guttata
100226356 Taeniopygia guttata
100080666 Ornithorhynchus anatinus
100402409 Callithrix jacchus
100453519 Pongo abelii
100482264 Ailuropoda melanoleuca
100602862 Nomascus leucogenys
496351 Xenopus laevis
422917 Gallus gallus
55818 Homo sapiens
475763 Canis lupus familiaris
536073 Bos taurus
104263 Mus musculus
312440 Rattus norvegicus
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