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decrease of PCMT1 (Montrer PCMT1 Kits ELISA) significantly increased the proportion of D-Asp (Montrer ASIP Kits ELISA) residues in PHB1 and had significant and fatal impacts on morphology and functions of the mitochondria, such as ATP production and the mitochondrial fusion-fission system
Endoplasmic reticulum resident chaperone GRP78 (Montrer HSPA5 Kits ELISA), mitochondrial protein (Montrer COX6B2 Kits ELISA) Prohibitin and heterogeneous nuclear ribonucleoprotein (Montrer PCBP2 Kits ELISA) hnRNPC (Montrer HNRNPC Kits ELISA) (C1/C2) have been shown to interact with viral RNA. Hence it is proposed that these are the principle candidates governing endoplasmic reticulum stress-induced apoptosis in JEV infection.
PHB1 down regulation suppresses liver cancer and bile duct cancer tumorigenesis.
PHB has an unexpected nuclear role in human embryonic stem cells that is required for self-renewal and that it acts with HIRA (Montrer HIRA Kits ELISA) in chromatin organization to link epigenetic organization to a metabolic circuit.
results demonstrate that the H19 (Montrer NCKAP1 Kits ELISA)-Igf2 axis is negatively regulated by CTCF (Montrer CTCF Kits ELISA)-PHB1 cooperation and that H19 (Montrer NCKAP1 Kits ELISA) is involved in modulating the growth-suppressive effect of PHB1 in the liver.
PHB promotes AR activation in ER-positive breast cancer.
High PHB expression is associated with breast cancer.
Data shows that PHB protein was overexpressed in gallbladder cancer tissues and significantly associated with histological grade, tumor stage and perineural invasion.
The present review focus is on recent developments in prohibitin (PHB) research in relation to ovarian granulosa cells physiological functions. [review]
We propose a model whereby in analogy to previous findings (e.g., the RAS-RAF (Montrer RAF1 Kits ELISA) signalling pathway), PHB can act as a signalling scaffold protein (Montrer HOMER1 Kits ELISA) to assist in KDELR-dependent Src (Montrer SRC Kits ELISA) activation
obesity-associated hyperinsulinemia promotes tumor development by facilitating dormant mutant to manifest and reveals a sex-dimorphic role of PHB in adipose-immune interaction or immunometabolism.
Study shows that PHB is highly expressed in white adipose tissue and liver which expression is regulated by estrogen.
This study identifies a novel signaling pathway composed of miR (Montrer MLXIP Kits ELISA)-361 and PHB1 that regulates mitochondrial fission program and apoptosis.
Both c-Myc (Montrer MYC Kits ELISA) and PHB1 directly interact with Nrf2 (Montrer NFE2L2 Kits ELISA) but c-Myc (Montrer MYC Kits ELISA) lowers Nrf2 (Montrer NFE2L2 Kits ELISA) binding to antioxidant response elemens while PHB1 enhances it.
A role for PHB in GnRH-induced cell death in mature gonadotropes, which is crucial for the normal development and function of the reproductive axis.
Data indicate that phosphorylation of Tyr114 and Tyr259 of prohibitin (PHB) is critical for the association of PHB with FcRI (Montrer FCGR1A Kits ELISA) and Syk (Montrer SYK Kits ELISA).
maintaining expression of intestinal epithelial cell prohibitin reduces the severity of inflammation and increases colonic levels of the antioxidants HO-1 (Montrer HMOX1 Kits ELISA) and NQO-1 (Montrer NQO1 Kits ELISA) via a mechanism independent of Nfe2 (Montrer NFE2 Kits ELISA)
Phb1/2 and the CD86 (Montrer CD86 Kits ELISA) cytoplasmic domain cooperate to mediate CD86 (Montrer CD86 Kits ELISA) signaling in a B cell through differential phosphorylation of distal signaling intermediates required to increase IgG1.
Findings suggest that PHB protects against colitis-associated cancer by modulating p53 (Montrer TP53 Kits ELISA)- and STAT3 (Montrer STAT3 Kits ELISA)-mediated apoptosis.
Data show that protein-tyrosine phosphatase (Montrer ACP1 Kits ELISA) PRP4A3 (prl3 (Montrer PTP4A3 Kits ELISA)) and van gogh like1 (vangl1 (Montrer Vangl1 Kits ELISA)) are Necessary Components in prohibitin1 (phb1) dependent neural crest specification.
Xphb1 represses E2F1 (Montrer E2F1 Kits ELISA) activity.
Prohibitin is involved in oxidative stress signaling in the retina and retinal pigment epithelium.
Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
, prohibitin protein Wph
, B-cell receptor-associated protein 32