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Cow (Bovine) Polyclonal RBM14 Primary Antibody pour WB - ABIN2778973
Sui, Yang, Xiong, Zhang, Blanchard, Peiper, Dynan, Tuan, Ko: Gene amplification and associated loss of 5' regulatory sequences of CoAA in human cancers. dans Oncogene 2007
RBM14 connects key paraspeckle subcomplexes via interactions mediated by its prion (Montrer PRNP Anticorps)-like domain.
This study identifies a cellular protein named RBM14 that is associated with XPO1 (CRM1 (Montrer XPO1 Anticorps)), a nuclear protein (Montrer RDBP Anticorps) that binds to the HIV-1 Rev protein and mediates nuclear export of incompletely spliced HIV-1 viral RNAs
upon RBM14 depletion, a part of the ectopic centriolar protein complexes in turn assemble into structures more akin to centrioles, presumably by incorporating HsSAS-6 (Montrer SASS6 Anticorps), a cartwheel component, and cause multipolar spindle formation.
RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation.
CoAA is involved in the migration-enhancing action of PEA3 (Montrer ETV4 Anticorps) on MCF7 metastatic human cancer cells.
SYT (Montrer SS18 Anticorps) interacts with SYT-interacting protein/co-activator activator
The CoAA gene is amplified in human cancers
CoAA is a potential tumor suppressor in renal carcinoma (Montrer TSC2 Anticorps) and CoAM is a counterbalancing splice isoform.
The alternative splicing imbalance of CoAA and RBM4 (Montrer RBM4 Anticorps), because of loss of their common enhancer in cancer, may deregulate stem/progenitor cell differentiation
CoAA binds Runx2 (Montrer RUNX2 Anticorps) and prevents Runx2 (Montrer RUNX2 Anticorps) binding to DNA; CoAA is expressed at high levels in human fetal osteoblasts and osteosarcoma cell lines
This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene.
RNA binding motif protein 14
, RNA-binding protein 14
, RRM-containing coactivator activator/modulator
, SYT-interacting protein
, paraspeckle protein 2
, synaptotagmin-interacting protein
, transmembrane protein 137
, RNA-binding motif protein 14
, synaptotagmin interacting protein
, coactivator activator