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anti-Human UBR5 Anticorps:
anti-Mouse (Murine) UBR5 Anticorps:
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Human Polyclonal UBR5 Primary Antibody pour ICC, IF - ABIN151138
Nash, Chen, Salganik, Muzyczka: Identification of cellular proteins that interact with the adeno-associated virus rep protein. dans Journal of virology 2008
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Human Polyclonal UBR5 Primary Antibody pour IHC (p), IHC - ABIN249850
Garbow, Doherty, Schugar, Travers, Weber, Wentz, Ezenwajiaku, Cotter, Brunt, Crawford: Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet. dans American journal of physiology. Gastrointestinal and liver physiology 2011
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Results found that EDD was consistent with GOLPH3 (Montrer GOLPH3 Anticorps) expression and also promoted the EMT (Montrer ITK Anticorps) process and activated Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling in epithelial ovarian cancer.
UBR5 directly binds to the tumor suppressor esophageal cancer-related gene 4, increasing its ubiquitination to reducing the protein stability of ECRG4 (Montrer C2orf40 Anticorps) to promote colorectal cancer progression.
Wnt (Montrer WNT2 Anticorps)-dependent inactivation of the Groucho/TLE co-repressor by the HECT E3 ubiquitin ligase (Montrer MUL1 Anticorps) Hyd/UBR5 is a key prerequisite that enables Armadillo/beta-catenin to activate transcription.
UBR5 downregulates proapoptotic MOAP-1 (Montrer MOAP1 Anticorps) and suggest that UBR5 can confer cisplatin resistance in ovarian cancer.
Data suggest that UBR5 down-regulates levels of TRAF3 (Montrer TRAF3 Anticorps), a key component of Toll (Montrer TLR4 Anticorps)-like receptor signaling, via the miRNA pathway; p90RSK (Montrer RPS6KA1 Anticorps) is an upstream regulator of UBR5; p90RSK (Montrer RPS6KA1 Anticorps) phosphorylates UBR5 as required for translational repression of TRAF3 (Montrer TRAF3 Anticorps) mRNA. (UBR5 = ubiquitin protein ligase E3 component n-recognin 5 protein; TRAF3 (Montrer TRAF3 Anticorps) = TNF receptor-associated factor 3 (Montrer TRAF3 Anticorps); p90RSK (Montrer RPS6KA1 Anticorps) = 90 kDa ribosomal protein S6 (Montrer RPS6 Anticorps) kinase (Montrer RPS6KB1 Anticorps))
Data show that ubiquitin protein ligase E3 component n-recognin 5 protein (UBR5) bound the tumor suppressor gastrokine 1 (GKN1 (Montrer GKN1 Anticorps)) and increased its ubiquitination to reduce the protein stability of GKN1 (Montrer GKN1 Anticorps).
Findings unveil UBR5 as a novel and critical regulator of tumor growth, metastasis, and immune response in triple negative breast cancer.
Study highlights many functional biological role of UBR5 especially in cancer where it seems to be a key regulator of cell signaling. [review]
Colony-formation assays and soft agar assays show that gain of function of TIP60 or depletion of EDD1 in HPV-positive cervical cancer cells significantly inhibits cell growth in vitro
Human herpesvirus-6 U14 induces cell cycle arrest in G2/M phase by associating with a cellular protein, EDD.
Hence, while loss of UBR5 perturbed Hedgehog (Montrer SHH Anticorps) signalling in the developing limb, there were no obvious morphological defects.
UBR5-mediated ATMIN (Montrer ATMIN Anticorps) ubiquitination is a vital event for ATM (Montrer ATM Anticorps) pathway selection and activation in response to DNA damage
a novel function of RIP1 (Montrer RALBP1 Anticorps) kinase involving its interaction with EDD to regulate JNK (Montrer MAPK8 Anticorps) activation and TNFalpha (Montrer TNF Anticorps) production.
Silencing Edd1 with shRNA in mouse embryonic stem cells significantly suppressed their growth.
The SCF (Montrer KITLG Anticorps) E3 ligase complex containing Fbxo40 (Montrer FBXO40 Anticorps) directly ubiquitinates IRS1 (Montrer IRS1 Anticorps), and this activity is enhanced by increased tyrosine phosphorylation of IRS1 (Montrer IRS1 Anticorps).
Through the PABC domain, EDD participates in miRNA silencing by recruiting downstream effectors.
UBR5 can attenuate myocardin (Montrer MYOCD Anticorps) protein degradation resulting in increased myocardin (Montrer MYOCD Anticorps) protein expression without affecting myocardin (Montrer MYOCD Anticorps) mRNA expression.
Results suggest that Edd has an essential role in extraembryonic development.
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.
E3 identified by differential display
, E3 ubiquitin protein ligase, HECT domain containing, 1
, E3 ubiquitin-protein ligase UBR5
, E3 ubiquitin-protein ligase, HECT domain-containing 1
, hyperplastic discs protein homolog
, progestin induced protein
, progestin-induced protein
, ubiquitin-protein ligase
, extraembryonic development