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HEK-293 Cells IgG1 Isotype Control

IsoC IgG1 unconjugated
N° du produit ABIN2181271
  • Antigène Tous les produits IgG1
    IgG1
    Activité biologique
    Active
    Reactivité
    Humain
    Hôte
    • 222
    • 43
    • 27
    • 9
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Application
    Isotype Control (IsoC)
    Attributs du produit
    This protein carries no "tag". The protein has a calculated MW of 26 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Pureté
    >95 % as determined by SDS-PAGE.
    Stérilité
    0.22 μm filtered
    niveau d'endotoxine
    Less than 1.0 EU per μg by the LAL method.
    Isotype
    IgG1
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
    Buffer
    50 mM Tris, 100 mM Glycine, pH 7.5
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C in lyophilized state after receipt. For long term storage, upon reconstitution rhIgG1 Fc should be aliquot and store at -20°C or -80°C.
  • Buecheler, Winzer, Tonillo, Weber, Gieseler: "Impact of Payload Hydrophobicity on the Stability of Antibody-Drug Conjugates." dans: Molecular pharmaceutics, Vol. 15, Issue 7, pp. 2656-2664, (2019) (PubMed).

    Tao, Zhang, Meraner, Tovaglieri, Wu, Gerhard, Zhang, Stallcup, Miao, He, Hurdle, Breault, Brass, Dong: "Frizzled proteins are colonic epithelial receptors for C. difficile toxin B." dans: Nature, Vol. 538, Issue 7625, pp. 350-355, (2017) (PubMed).

    Zhou, Wang, Tong, Okamoto, Shen, Zaro: "Single chain Fc-dimer-human growth hormone fusion protein for improved drug delivery." dans: Biomaterials, Vol. 117, pp. 24-31, (2017) (PubMed).

    West, Pan, Tonsing-Carter, Hernandez, Pierce, Styke, Bowie, Garcia, Kocherginsky, Conzen: "GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER+ Breast Cancer Outcome." dans: Molecular cancer research : MCR, Vol. 14, Issue 8, pp. 707-19, (2017) (PubMed).

    Grenga, Kwilas, Donahue, Farsaci, Hodge: "Inhibition of the angiopoietin/Tie2 axis induces immunogenic modulation, which sensitizes human tumor cells to immune attack." dans: Journal for immunotherapy of cancer, Vol. 3, pp. 52, (2015) (PubMed).

  • Antigène
    IgG1
    Abstract
    IgG1 Produits
    Synonymes
    IgG1 Isotype Control, Igh-4 Isotype Control, VH7183 Isotype Control, immunoglobulin heavy constant gamma 1 (G1m marker) Isotype Control, Ighg1 Isotype Control
    Classe de substances
    Antibody
    Sujet
    Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.
    Poids moléculaire
    26 kDa
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