Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher toutes les espèces
Afficher tous les synonymes
Select your species
identified the second mutation in CEP135, confirming the role during embryonic brain development and in the pathophysiology of human primary microcephaly
Authors suggest that the decrease in CEP135(mini) from centrosomes promotes centriole assembly. The repression of centriole duplication by a splice isoform of a protein that normally promotes it serves as a novel mechanism to limit centriole duplication.
These findings support a model in which PKC-mediated phosphorylation of CEP4 at Ser (Montrer SIGLEC1 Kits ELISA)(18) and Ser (Montrer SIGLEC1 Kits ELISA)(80) causes its dissociation from Cdc42 (Montrer CDC42 Kits ELISA), thereby increasing its affinity for TEM4 and producing Rac (Montrer AKT1 Kits ELISA) activation, filopodium formation, and cell motility
Authors propose that CEP135 directly connects the central hub protein, hSAS (Montrer L1CAM Kits ELISA)-6, to the outer microtubules, and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP (Montrer CENPJ Kits ELISA)-mediated centriole elongation.
A truncating mutation of CEP135 caused autosomal-recessive primary microcephaly in a Pakistani family.
CEP135 acts as a platform protein for C-NAP1 (Montrer CEP250 Kits ELISA) at the centriole.
This gene encodes a centrosomal protein, which acts as a scaffolding protein during early centriole biogenesis, and is also required for centriole-centriole cohesion during interphase. Mutations in this gene are associated with autosomal recessive primary microcephaly-8.
centrosomal protein 135kDa
, centrosome protein 4
, centrosomal protein of 135 kDa
, centrosome protein 4-like
, centrosomal protein of 135 kDa-like
, centrosomal protein 4
, centrosome protein cep135