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anti-Mouse (Murine) Dynamitin Anticorps:
anti-Human Dynamitin Anticorps:
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Human Polyclonal Dynamitin Primary Antibody pour IF, WB - ABIN523956
Chatin, Colombier, Gamblin, Allouis, Le Bouffant: Dynamitin affects cell-surface expression of voltage-gated sodium channel Nav1.5. dans The Biochemical journal 2014
Dmn may play an important role in Drosophila spermiogenesis by affecting transport of many important cytoplasmic materials.
Our results suggest a model whereby endocytic activity recruits Dynein to the oocyte cortex. The motor along with its regulators, Dynactin (Montrer DCTN1 Anticorps) and Lis1 (Montrer PAFAH1B1 Anticorps), functions to ensure efficient endocytic uptake and maturation.
Altered levels of Cep135 (Montrer CEP135 Anticorps) and p50 (Montrer LSP1 Anticorps) by RNAi and protein overexpression caused the release of endogenous partner molecules from centrosomes.
This is the first time a haplotype on chromosome 12 containing sequence variants in the genes DCTN2, DNAH10 (Montrer DNAH10 Anticorps), LRIG3, and MYO1A (Montrer MYO1A Anticorps) has been linked to an inherited neuropathy in humans.
dynamitin is involved in the regulation of Nav1.5 (Montrer SCN5A Anticorps) cell-surface density
the determinants of p50 (Montrer CD40 Anticorps)/DM required for self-oligomerization of the protein and for interactions with other subunits of the dynactin (Montrer DCTN1 Anticorps) complex
Altered levels of Cep135 (Montrer CEP135 Anticorps) and p50 (Montrer CD40 Anticorps) by RNAi and protein overexpression caused the release of endogenous partner molecules from centrosomes.
the Sec23p component of the COPII complex directly interacts with the dynactin (Montrer DCTN1 Anticorps) complex through the carboxy-terminal cargo-binding domain of p150(Glued (Montrer DCTN1 Anticorps)).
DCTN2 is required in the earliest stages of peroxisome biogenesis.
study does not support a major role for DCTN2 overexpression in carcinogenesis
Data show how dynamitin's different structural domains contribute to its ability to self-associate, interact with dynactin (Montrer DCTN1 Anticorps) and assemble into a complex with its close binding partner, p24.
The interaction between ZW10 (Montrer ZW10 Anticorps) and dynamitin showed that the N-terminal region of ZW10 (Montrer ZW10 Anticorps) is the major binding site for dynamitin and, like full-length ZW10 (Montrer ZW10 Anticorps), could move along microtubules to the centrosomal area in a dynein-dynactin (Montrer DCTN1 Anticorps)-dependent manner.
These results indicate that the p50 (Montrer ARHGEF7 Anticorps) component of the dynactin (Montrer DCTN1 Anticorps) complex is essential for the survival of sensory neurons and the maintenance of ganglion cell axons, and functions as a major determinant of apicobasal polarity in retinal radial glia.
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
dynactin 2 (p50)
, dynactin subunit 2
, dynactin subunit 2-B
, p50 dynamitin
, 50 kDa dynein-associated polypeptide
, dynactin complex 50 kDa subunit
, growth cone membrane protein 23-48K
, 50 kD dynein-associated polypeptide
, dynactin complex 50 kD subunit
, dynactin subunit 2-A