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anti-Mouse (Murine) NEK2 Anticorps:
anti-Rat (Rattus) NEK2 Anticorps:
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Human Polyclonal NEK2 Primary Antibody pour WB - ABIN392650
Chen, Riley, Zheng, Chen, Lee: Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation. dans The Journal of biological chemistry 2002
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Human Polyclonal NEK2 Primary Antibody pour IF (p), IHC (p) - ABIN713921
Zhong, Guan, Dong, Yang, Liu, Zhang: Examining Nek2 as a better proliferation marker in non-small cell lung cancer prognosis. dans Tumour biology 2014
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Human Monoclonal NEK2 Primary Antibody pour IHC (f), IF - ABIN968054
Fry, Schultz, Bartek, Nigg: Substrate specificity and cell cycle regulation of the Nek2 protein kinase, a potential human homolog of the mitotic regulator NIMA of Aspergillus nidulans. dans The Journal of biological chemistry 1995
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Human Monoclonal NEK2 Primary Antibody pour IHC (f), IF - ABIN968053
Schultz, Fry, Sütterlin, Ried, Nigg: Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans. dans Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994
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Cep85 is a bona fide Nek2A-binding partner that surrounds the proximal ends of centrioles where it cooperates with PP1gamma (also known as PPP1CC (Montrer PPP1CC Anticorps)) to antagonize Nek2A
The results suggest that overexpression of NEK2 has the potential to serve as a biomarker for PCa (Montrer ENPP1 Anticorps) prognosis.
Nek2 transgenic mice develop spontaneous germinal centers and exhibit an enhanced T cell dependent immune response our data demonstrates a novel role for Nek2 in regulating B cell development and the immune response
these data indicate that Nek2 has a pivotal role in breast cancer growth at primary and secondary sites, and thus may be an attractive and novel therapeutic target for this disease.
CIP2A (Montrer KIAA1524 Anticorps) strongly interacts with NEK2 during G2/M phase, thereby enhancing NEK2 kinase activity to facilitate centrosome separation in a PP1 (Montrer PPP1CC Anticorps)- and PP2A (Montrer PPP2R2B Anticorps)-independent manner.
Nek2 and its substrate, centrobin/Nip2, are required for proper meiotic spindle formation of the mouse oocytes
Data show that NEK2 was identified as a tumor-associated antigen.
Nek2 may be a mitotic regulator that is involved in diverse cell cycle events.
Tcp10 promoter-directed expression of the Nek2 gene in mouse meiotic spermatocytes.
The MAPK (Montrer MAPK1 Anticorps) pathway triggers activation of Nek2 during chromosome condensation in mouse spermatocytes.
NEK2 promotes aerobic glycolysis through regulating splicing of PKM and increasing the PKM2/PKM1 ratio in myeloma cells which contributes to its oncogenic activity.
Nek2A is found to stabilize SuFu (Montrer SUFUH Anticorps) at least partly depending on its kinase activity, thereby triggering phosphorylation of the SuFu (Montrer SUFUH Anticorps) protein.
NEK2 has a role in maintaining glioma stem cells in glioblastoma by stabilizing the EZH2 (Montrer EZH2 Anticorps) protein
This study reports a novel set of Dengue virus (DENV) NS1-interacting host cell proteins in the HepG2 cell line and proposes possible roles for human NEK2, TAO1, and COG1 in DENV infection.
NEK2 modulates hepatoma cell functions, including growth, drug resistance, metastasis and angiogenesis via downstream genes activation
Alteration of NEK2 protein levels may contribute to invasion and metastasis of hepatocellular carcinoma
the functional roles of NEK2 in cancer development (review)
NEK2 was associated with unfavorable outcomes in HCC (Montrer FAM126A Anticorps) patients.
enhanced NEK2 expression in hepatocellular carcinoma (HCC (Montrer FAM126A Anticorps)) promotes HCC (Montrer FAM126A Anticorps) progression and drug resistance by promoting PP1 (Montrer PPA1 Anticorps)/Akt (Montrer AKT1 Anticorps) and Wnt (Montrer WNT2 Anticorps) pathway activation, which may represent a new therapeutic target for HCC (Montrer FAM126A Anticorps).
Our findings demonstrated that NEK2 could be a valuable carcinogenic factor and a promising therapeutic target for primary liver cancer
This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene.
NIMA (never in mitosis gene a)-related kinase 2
, NIMA - related expressed kinase 2
, NIMA-related expressed kinase 2
, NIMA-related kinase 2
, Nek2 kinase
, never in mitosis A-related kinase 2
, nimA-related protein kinase 2
, serine/threonine-protein kinase Nek2
, serine/threonine protein kinase Nek2
, nimA-like protein kinase 1