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Human Monoclonal PPP1CA Primary Antibody pour ELISA, WB - ABIN969360
Chen, Kesler, Paschal, Balk: Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1. dans The Journal of biological chemistry 2009
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Human Monoclonal PPP1CA Primary Antibody pour ELISA, WB - ABIN969359
Luo, Peterson, Garcia, Coombs, Kofahl, Heinrich, Shabanowitz, Hunt, Yost, Virshup: Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. dans The EMBO journal 2007
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Data, including data from studies using transgenic/knockout mice, suggest that Ppp1ca and Gnb1 (Montrer GNB1 Anticorps) interact in quiescent platelets; then, Ppp1ca and Plcb3 (Montrer PLCB3 Anticorps) interact during platelet aggregation; thus, Gnb1 (Montrer GNB1 Anticorps) enlists Ppp1ca to modulate G protein-coupled receptor (Montrer GPR34 Anticorps) signaling. (Ppp1ca = protein phosphatase 1 (Montrer PPP1CB Anticorps), catalytic subunit alpha; Gnb1 (Montrer GNB1 Anticorps) = guanine nucleotide-binding protein (Montrer TRIM23 Anticorps), subunit beta-1; Plcb3 (Montrer PLCB3 Anticorps) = phospholipase C (Montrer PLC Anticorps), subunit beta-3)
findings demonstrate a novel regulatory circuit in which STING and TBK1 (Montrer TBK1 Anticorps) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A (Montrer PPM1A Anticorps) dephosphorylates STING and TBK1 (Montrer TBK1 Anticorps)
the studies presented here position PPM1A (Montrer PPM1A Anticorps) as a new player in the wound healing-inflammation-angiogenesis axis in mouse, reveal its crucial role in homeostasis on injury, and highlight its potential as a therapeutic mediator in pathologic conditions
Ang (Montrer ANG Anticorps) IV functions via regulating the activity of PP1 (Montrer PPP1CC Anticorps)
a nuclear envelope-localized mechanism of inactivating TGF-beta (Montrer TGFB1 Anticorps) signaling in which MAN1 (Montrer LEMD3 Anticorps) competes with transcription factors for binding to Smad2 (Montrer SMAD2 Anticorps) and Smad3 (Montrer SMAD3 Anticorps) and facilitates their dephosphorylation by PPM1A (Montrer PPM1A Anticorps).
Although a non-myristoylated mutation (G2A (Montrer GPR132 Anticorps)) of PPM1A (Montrer PPM1A Anticorps) and PPM1B (Montrer PPM1B Anticorps) prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha (Montrer GRK4 Anticorps).
we found that PPM1A (Montrer PPM1A Anticorps) mRNA is synthesized at the beginning of the maturation process and remains elevated in the mature oocytes, promoting the accumulation of PPM1A (Montrer PPM1A Anticorps) protein
Cell surface expression of the major amyloid-beta peptide (Abeta (Montrer APP Anticorps))-degrading enzyme, neprilysin (Montrer MME Anticorps), depends on phosphorylation by mitogen-activated protein kinase (Montrer MAPK1 Anticorps)/extracellular signal-regulated kinase kinase (MEK (Montrer MDK Anticorps)) and dephosphorylation by protein phosphatase 1a (Montrer PPM1A Anticorps).
analysis of selective regulation of NR2B (Montrer GRIN2B Anticorps) by protein phosphatase-1 (Montrer PPP1CB Anticorps) for the control of the NMDA receptor in neuroprotection
Protein phosphatase PPM1A (Montrer PPM1A Anticorps) regulates the nuclear export of Smad2 (Montrer SMAD2 Anticorps)/3 through targeting nuclear exporter RanBP3 (Montrer RANBP3 Anticorps).
establish PPM1A (Montrer PPM1A Anticorps) as a novel repressor of the SMAD3 (Montrer SMAD3 Anticorps) pathway in renal fibrosis
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a (Montrer EIF2S1 Anticorps) phosphorylation by inhibiting PPP1CA via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (Montrer ATF4 Anticorps) expression. (eIF2a (Montrer EIF2S1 Anticorps) = eukaryotic initiation factor-2alpha (Montrer EIF2S1 Anticorps); PPP1CA = protein phosphatase 1 catalytic subunit alpha; Atf4 (Montrer ATF4 Anticorps) = activating transcription factor 4 (Montrer ATF4 Anticorps))
Report a tumor-suppressive function of PPM1A (Montrer PPM1A Anticorps) and an independent relationship to Smad4 (Montrer SMAD4 Anticorps) in pancreatic ductal adenocarcinoma.
Protein phosphatase 1 (Montrer PPP1CB Anticorps) (PP1 (Montrer PPA1 Anticorps)) forms stable complexes with PP1 (Montrer PPA1 Anticorps)-interacting proteins (PIPs (Montrer GPRASP1 Anticorps)) that guide the phosphatase throughout its life cycle and control its fate and function.
The authors found that RNA recognition motif 1 (RRM1 (Montrer RRM1 Anticorps)) in SRSF1 (Montrer SRSF1 Anticorps) binds PP1 (Montrer PPA1 Anticorps) and represses its catalytic function through an allosteric mechanism.
this study shows a pivotal role for PP1 (Montrer PPA1 Anticorps) in impeding IRF7 (Montrer IRF7 Anticorps)-mediated IFN-alpha (Montrer IFNA Anticorps) production in host immune responses
hydrogen/deuterium exchange-mass spectrometry and molecular dynamics to characterize conformational changes in PP2Calpha (Montrer PPM1A Anticorps) between the active and inactive states
In a nested case control study of ischemic stroke, there was an epigenome-wide association for cg04985020 (PPM1A (Montrer PPM1A Anticorps); P=1.78x10(-07)) with vascular recurrence in patients treated with aspirin.
The data support a model where Cdc7 (Montrer CDC7 Anticorps) (de)phosphorylation is the molecular switch for the activation and inactivation of DNA replication in mitosis, directly connecting Cdc7 (Montrer CDC7 Anticorps) and PP1a/Cdk1 (Montrer CDK1 Anticorps) to the regulation of once-per-cell cycle DNA replication in mammalian cells.
These results indicate that PP1 (Montrer PPA1 Anticorps) is recruited to the extracellular calcium-dependent E-cadherin (Montrer CDH1 Anticorps)-catenin-PIP5K1a (Montrer PIP5K1A Anticorps) complex in the plasma membrane to activate PIP5K1a (Montrer PIP5K1A Anticorps), which is required for PLC (Montrer HSPG2 Anticorps)-g1 activation leading to keratinocyte differentiation.
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Protein phosphatase type 1 alpha, catalytic subunit
, protein phosphatase 1, catalytic subunit, alpha isoform
, serine/threonine-protein phosphatase PP1-alpha catalytic subunit
, protein phosphatase 1, catalytic subunit, alpha
, serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit
, protein phosphatase-1d
, protein phosphatase 1, catalytic subunit, beta isoform
, protein phosphatase-1a
, serine/threonine-protein phosphatase PP1-beta catalytic subunit
, Mpp alpha
, protein phosphatase 1A
, protein phosphatase 2C isoform alpha
, protein phosphatase IA
, protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
, protein phosphatase 2C alpha