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Data, including data from studies using transgenic/knockout mice, suggest that Ppp1ca and Gnb1 (Montrer GNB1 Kits ELISA) interact in quiescent platelets; then, Ppp1ca and Plcb3 (Montrer PLCB3 Kits ELISA) interact during platelet aggregation; thus, Gnb1 (Montrer GNB1 Kits ELISA) enlists Ppp1ca to modulate G protein-coupled receptor (Montrer GPR34 Kits ELISA) signaling. (Ppp1ca = protein phosphatase 1 (Montrer PPP1CB Kits ELISA), catalytic subunit alpha; Gnb1 (Montrer GNB1 Kits ELISA) = guanine nucleotide-binding protein (Montrer TRIM23 Kits ELISA), subunit beta-1; Plcb3 (Montrer PLCB3 Kits ELISA) = phospholipase C (Montrer PLC Kits ELISA), subunit beta-3)
findings demonstrate a novel regulatory circuit in which STING and TBK1 (Montrer TBK1 Kits ELISA) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A (Montrer PPM1A Kits ELISA) dephosphorylates STING and TBK1 (Montrer TBK1 Kits ELISA)
the studies presented here position PPM1A (Montrer PPM1A Kits ELISA) as a new player in the wound healing-inflammation-angiogenesis axis in mouse, reveal its crucial role in homeostasis on injury, and highlight its potential as a therapeutic mediator in pathologic conditions
Ang (Montrer ANG Kits ELISA) IV functions via regulating the activity of PP1 (Montrer PPP1CC Kits ELISA)
a nuclear envelope-localized mechanism of inactivating TGF-beta (Montrer TGFB1 Kits ELISA) signaling in which MAN1 (Montrer LEMD3 Kits ELISA) competes with transcription factors for binding to Smad2 (Montrer SMAD2 Kits ELISA) and Smad3 (Montrer SMAD3 Kits ELISA) and facilitates their dephosphorylation by PPM1A (Montrer PPM1A Kits ELISA).
Although a non-myristoylated mutation (G2A) of PPM1A (Montrer PPM1A Kits ELISA) and PPM1B (Montrer PPM1B Kits ELISA) prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha (Montrer GRK4 Kits ELISA).
we found that PPM1A (Montrer PPM1A Kits ELISA) mRNA is synthesized at the beginning of the maturation process and remains elevated in the mature oocytes, promoting the accumulation of PPM1A (Montrer PPM1A Kits ELISA) protein
Cell surface expression of the major amyloid-beta peptide (Abeta (Montrer APP Kits ELISA))-degrading enzyme, neprilysin (Montrer MME Kits ELISA), depends on phosphorylation by mitogen-activated protein kinase (Montrer MAPK1 Kits ELISA)/extracellular signal-regulated kinase kinase (MEK (Montrer MDK Kits ELISA)) and dephosphorylation by protein phosphatase 1a (Montrer PPM1A Kits ELISA).
analysis of selective regulation of NR2B (Montrer GRIN2B Kits ELISA) by protein phosphatase-1 (Montrer PPP1CB Kits ELISA) for the control of the NMDA receptor in neuroprotection
Protein phosphatase PPM1A (Montrer PPM1A Kits ELISA) regulates the nuclear export of Smad2 (Montrer SMAD2 Kits ELISA)/3 through targeting nuclear exporter RanBP3 (Montrer RANBP3 Kits ELISA).
establish PPM1A (Montrer PPM1A Kits ELISA) as a novel repressor of the SMAD3 (Montrer SMAD3 Kits ELISA) pathway in renal fibrosis
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a (Montrer EIF2S1 Kits ELISA) phosphorylation by inhibiting PPP1CA via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (Montrer ATF4 Kits ELISA) expression. (eIF2a (Montrer EIF2S1 Kits ELISA) = eukaryotic initiation factor-2alpha (Montrer EIF2S1 Kits ELISA); PPP1CA = protein phosphatase 1 catalytic subunit alpha; Atf4 (Montrer ATF4 Kits ELISA) = activating transcription factor 4 (Montrer ATF4 Kits ELISA))
Report a tumor-suppressive function of PPM1A (Montrer PPM1A Kits ELISA) and an independent relationship to Smad4 (Montrer SMAD4 Kits ELISA) in pancreatic ductal adenocarcinoma.
Protein phosphatase 1 (Montrer PPP1CB Kits ELISA) (PP1 (Montrer PPA1 Kits ELISA)) forms stable complexes with PP1 (Montrer PPA1 Kits ELISA)-interacting proteins (PIPs (Montrer GPRASP1 Kits ELISA)) that guide the phosphatase throughout its life cycle and control its fate and function.
The authors found that RNA recognition motif 1 (RRM1 (Montrer RRM1 Kits ELISA)) in SRSF1 (Montrer SRSF1 Kits ELISA) binds PP1 (Montrer PPA1 Kits ELISA) and represses its catalytic function through an allosteric mechanism.
this study shows a pivotal role for PP1 (Montrer PPA1 Kits ELISA) in impeding IRF7 (Montrer IRF7 Kits ELISA)-mediated IFN-alpha (Montrer IFNA Kits ELISA) production in host immune responses
hydrogen/deuterium exchange-mass spectrometry and molecular dynamics to characterize conformational changes in PP2Calpha (Montrer PPM1A Kits ELISA) between the active and inactive states
In a nested case control study of ischemic stroke, there was an epigenome-wide association for cg04985020 (PPM1A (Montrer PPM1A Kits ELISA); P=1.78x10(-07)) with vascular recurrence in patients treated with aspirin.
The data support a model where Cdc7 (Montrer CDC7 Kits ELISA) (de)phosphorylation is the molecular switch for the activation and inactivation of DNA replication in mitosis, directly connecting Cdc7 (Montrer CDC7 Kits ELISA) and PP1a/Cdk1 (Montrer CDK1 Kits ELISA) to the regulation of once-per-cell cycle DNA replication in mammalian cells.
These results indicate that PP1 (Montrer PPA1 Kits ELISA) is recruited to the extracellular calcium-dependent E-cadherin (Montrer CDH1 Kits ELISA)-catenin-PIP5K1a complex in the plasma membrane to activate PIP5K1a, which is required for PLC (Montrer HSPG2 Kits ELISA)-g1 activation leading to keratinocyte differentiation.
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Protein phosphatase type 1 alpha, catalytic subunit
, protein phosphatase 1, catalytic subunit, alpha isoform
, serine/threonine-protein phosphatase PP1-alpha catalytic subunit
, protein phosphatase 1, catalytic subunit, alpha
, serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit
, protein phosphatase-1d
, protein phosphatase 1, catalytic subunit, beta isoform
, protein phosphatase-1a
, serine/threonine-protein phosphatase PP1-beta catalytic subunit
, Mpp alpha
, protein phosphatase 1A
, protein phosphatase 2C isoform alpha
, protein phosphatase IA
, protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
, protein phosphatase 2C alpha