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MYPT2 is truly the regulatory subunit of cardiac myosin phosphatase in-vivo and plays a significant role in modulating cardiac function.
PPP1R12B is associated with childhood asthma in a Russian population.
Results describe the characterization and function of MYPT2, a target subunit of myosin phosphatase in heart.
analysis of the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase
Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome.
protein phosphatase 1 regulatory subunit 12B
, protein phosphatase 1, regulatory (inhibitor) subunit 12B
, myosin phosphatase target subunit 2
, myosin phosphatase-targeting subunit 2
, myosin phosphatase, target subunit 2