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Cerberus binds and inhibits Nodal, Activin B (Montrer Actbeta Kits ELISA), BMP-6 (Montrer BMP6 Kits ELISA), and BMP-7 (Montrer BMP7 Kits ELISA) but not BMP-2 (Montrer BMP2 Kits ELISA) or Activin A (Montrer INHBA Kits ELISA).
No significant association between the studied DKK1 (Montrer DKK1 Kits ELISA) variations and osteoporosis was found, while CER1 variations seem to play a significant role in the determination of osteoporosis, combined with bone markers, in postmenopausal osteoporotic women.
results show that Cer1 (or CER1) serves as a good marker for quantification of definitive endoderm differentiation of mouse and human ES/iPS (Montrer SLC27A4 Kits ELISA) cells
CER1 gene variations play a significant role in determining BMD (Montrer BEST1 Kits ELISA) and vertebral or hip fractures, which might be helpful in clinical practice to identify patients with increased fracture risk
successful identification of an association with CER1 in humans together with our mouse study suggests that CER1 may play a role in the development of bone or its metabolism
This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity.
DAN domain family member 4
, cerberus 1, cysteine knot superfamily, homolog
, cerberus-related 1
, cerberus-related protein