Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher toutes les espèces
Afficher tous les synonymes
Select your species
Structure of ALR1 in ternary complex with NADPH and 3,5-dichlorosalicylic acid is reported as well as the implications for inhibitor binding and selectivity.
L-idose is the best alternative to D-glucose in studies on aldose reductase.
prostaglandin F synthase (Montrer AKR1C3 Kits ELISA) activity of human and bovine aldo-keto reductases
Aldehyde reductase exerts a protective effect against carbon tetrachloride-induced hepatic steatosis by replenishing ascorbic acid via its antioxidative properties.
Aldose reductase acts as a switch which can regulate microglia by polarizing cells after spinal cord injury.
Aldose reductase contributes to diabetes-mediated mitochondrial dysfunction and damage through the activation of p53 (Montrer TP53 Kits ELISA).
Data indicate that inhibition of AR alleviates the MCD (Montrer MLYCD Kits ELISA) diet-induced liver inflammation and fibrosis in db/db (Montrer LEPR Kits ELISA) mice, probably through dampening CYP2E1 (Montrer CYP2E1 Kits ELISA) mediated-oxidative stress and ameliorating the expression of pro-inflammatory cytokines.
FMHM suppressed the activity of AR-dependent phospholipase C (Montrer PLC Kits ELISA)/protein kinase C (Montrer PKC Kits ELISA) signaling, which further resulted in downstream inactivation of the IkappaB kinase (Montrer CHUK Kits ELISA)/IkappaB/nuclear factor-kappa B inflammatory pathway.
Allergen-induced airway remodeling is mediated by AR and its inhibition blocks the progression of remodeling via inhibiting TGFbeta1 (Montrer TGFB1 Kits ELISA)-induced Smad (Montrer SMAD1 Kits ELISA)-independent and PI3K/AKT (Montrer AKT1 Kits ELISA)/GSK3beta (Montrer GSK3b Kits ELISA)-dependent pathway.
BGG-mediated inhibition of aldose reductase prevented LPS (Montrer TLR4 Kits ELISA)-induced activation of JNK (Montrer MAPK8 Kits ELISA).
The crystal structure of AKR1a4 in its apo (Montrer C9orf3 Kits ELISA) form at high resolution.
crystal of AKR1B3 was tetragonal, belonging to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 107.62, c = 120.76 A
the role of AKR1B3 in regulating advanced glycosylation end products and advanced lipoxidation end products
An meta-analysis showed that aldose reductase C-106T variants appear to influence the risk for diabetic retinopathy in Chinese Han persons (meta-analysis).
AKR1B1 as a key modulator of tumor aggressiveness and suggests that pharmacologic inhibition of AKR1B1 has the potential to become a valuable therapeutic strategy for Basal-like breast cancer (BLBC).
Result indicate that the differential scanning fluorimetry (DSF) method is useful for enzyme inhibitor drug screening for the AKR superfamily, including AKR1B10 (Montrer AKR1B10 Kits ELISA) and a structurally similar isoform AKR1B1.
The hyperosmotic AR gene expression was dependent on activation of metalloproteinases, autocrine/paracrine TGF-beta (Montrer TGFB1 Kits ELISA) signaling, activation of p38 MAPK (Montrer MAPK14 Kits ELISA), ERK1/2 (Montrer MAPK1/3 Kits ELISA), and PI3K (Montrer PIK3CA Kits ELISA) signal transduction pathways, and the transcriptional activity of NFAT5 (Montrer NFAT5 Kits ELISA).
Aberrant DNA methylation (Montrer HELLS Kits ELISA) of AKR1B1 could be potential screening markers of colorectal cancer.
-106T allele of AKR1B1 C-106T polymorphism may be associated with increased risk for essential hypertension in Chinese Han population.
These findings suggest a statistically significant association of AKR1B1 -106C>T polymorphism with retinopathy in North Indian patients
ALR (Montrer GFER Kits ELISA) C(-106)T polymorphism was not associated with an increased risk of Diabetic Retinopathy; subgroup analysis showed a genetic association between ALR (Montrer GFER Kits ELISA) C(-106)T polymorphism and the risk of Diabetic Retinopathy of type 1 Diabetes but not Diabetic Retinopathy of type 2 Diabetes(Meta-Analysis)
Higher expression of PLA2G2A (Montrer PLA2G2A Kits ELISA), PTGS2 (Montrer PTGS2 Kits ELISA), AKR1B1, AKR1C3 (Montrer AKR1C3 Kits ELISA) and ABCC4 (Montrer ABCC4 Kits ELISA) was seen in 22-B endometriosis cells.
Data conclude that AKR1B1 and TM6SF1 may serve as candidate methylation biomarkers for early breast cancer detection.
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database.
aldo-keto reductase family 1, member B1-like
, aldose reductase
, aldo-keto reductase family 1, member B1 (aldose reductase)
, alcohol dehydrogenase
, alcohol dehydrogenase [NADP(+)]
, aldehyde reductase
, aldo-keto reductase family 1 member A1
, aldo-keto reductase family 1, member A4 (aldehyde reductase)
, 3-DG-reducing enzyme
, Lii5-2 CTCL tumor antigen
, aldehyde reductase 1
, aldo-keto reductase family 1 member B1
, low Km aldose reductase
, 20-alpha-hydroxysteroid dehydrogenase
, Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene)
, aldo-keto reductase family 1, member B4 (aldose reductase)