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anti-Mouse (Murine) POMC Anticorps:
anti-Human POMC Anticorps:
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Human Polyclonal POMC Primary Antibody pour ELISA, IHC - ABIN250413
Mühlhäusler, Adam, Marrocco, Findlay, Roberts, McFarlane, Kauter, McMillen et al.: Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late ... dans The Journal of physiology 2005
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Human Polyclonal POMC Primary Antibody pour FACS, IF (p) - ABIN673209
Chao, Lu, Lee, Chen, Wang, Yang, Cheng, Liao, Ro: Early systemic granulocyte-colony stimulating factor treatment attenuates neuropathic pain after peripheral nerve injury. dans PLoS ONE 2012
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We identify the neuronal regulatory region of zebrafish pomca and confirm that it is not homologous to the mammalian enhancers.
Hypothalamic pro-opiomelanocortin and AgRP (Montrer AGRP Anticorps) neurons are hypophysiotropic, projecting to the pituitary to coordinately regulate multiple pituitary hormones.
cloning and characterization of the pro-opiomelanocortin gene
Zebrafish proopiomelanocortin (zfPOMC) contains the consensus sequences for ACTH, gamma-LPH, beta-MSH and beta-endorphin (beta-END). RT-PCR expression studies indicate that zfPOMC is selectively expressed in nervous tissue and in the pituitary gland.
Pituitary expression of proopiomelanocortin provides a unique marker for pituitary anterior and intermediate lobe morphogenesis.
disruption of this hippocampal POMC/MC4R (Montrer MC4R Anticorps) circuit might contribute to synaptic dysfunction observed in Alzheimer's disease.
The data show that somatic MORs in POMC neurons couple to multiple effectors that have differential sensitivity to desensitization of the receptor.
These findings indicate that the relevance of AgRP (Montrer AGRP Anticorps) to POMC neuron GABA connectivity depends on the state of AgRP (Montrer AGRP Anticorps) neuron activity and suggest that different types of transmitter release should be considered when circuit mapping.
these data unmasked a role for mitochondrial fission in leptin (Montrer LEP Anticorps) sensitivity and glucose sensing of POMC neurons.
it is suggested that the suppression of NeuroD1 (Montrer NEUROD1 Anticorps) expression and the inhibition of NeuroD1 (Montrer NEUROD1 Anticorps)/E-box interaction may play an important role in the Gc-mediated negative regulation of Pomc.
To clarify the functional roles of the AKT (Montrer AKT1 Anticorps)-mTOR (Montrer FRAP1 Anticorps) pathway in the hippocampal neurons, we generated conditional knockout mice harboring the deletion of Pten (Pten (Montrer PTEN Anticorps)-cKO) in Proopiomelanocortin-expressing neurons.
Epo (Montrer EPO Anticorps) regulates hypothalamus POMC expression via STAT3 (Montrer STAT3 Anticorps) activation.
Data suggest that the solitary tract pro-opiomelanocortin (NTSPOMC) neurons were involved in cardiorespiratory control and endogenous analgesia.
hypothalamic arcuate nucleus (Arc (Montrer NOL3 Anticorps))POMC-deficient mice, which develop severe obesity and insulin (Montrer INS Anticorps) resistance, unexpectedly exhibit improved glucose tolerance and remain protected from hyperglycemia via decreased renal GLUT2 (Montrer SLC2A2 Anticorps) expression and glycosuria.
Hypomethylation of POMC promoter occurred in the hypothalamus of the high sucrose diet offspring compared with controls.
Elevated ACTH secretion is associated with Cushing's syndrome.
a novel p53 (Montrer TP53 Anticorps)/POMC/Galphas (Montrer GNAS Anticorps)/SASH1 (Montrer SASH1 Anticorps) autoregulatory positive feedback loop is regulated by SASH1 (Montrer SASH1 Anticorps) mutations to induce pathological hyperpigmentation phenotype.
Data suggest that alpha-MSH enhances cell adhesion to fibronectin (Montrer FN1 Anticorps) in primary mixed synoviocytes obtained from osteoarthritis patients; alpha-MSH reduces secretion of cytokines (TNF (Montrer TNF Anticorps), IL-6 (Montrer IL6 Anticorps) and IL-8 (Montrer IL8 Anticorps)) in such synoviocyte cultures.
Data suggest that the first screening step diagnosis for pituitary adenoma was determined based upon immunohistochemical (IHC) scores for Pit-1 (Montrer POU1F1 Anticorps), SF-1 (Montrer NR5A1 Anticorps), and ACTH.
The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R (Montrer MC4R Anticorps)), pro-opiomelanocortin (POMC), apolipoprotein E (APOE (Montrer APOE Anticorps)) and agouti-related protein (AGRP (Montrer AGRP Anticorps)) with obesity in the North Indian population.
The expression of Pomc mRNA was stimulated in the arcuate nucleus after skin exposure to UVB.
hsa (Montrer CD24 Anticorps)-miR (Montrer MLXIP Anticorps)-34a can regulate the CRH (Montrer CRH Anticorps)/CRHR1 (Montrer CRHR1 Anticorps)/POMC axis and may influence body mass index.
these common variants in PCSK1 (Montrer PCSK1 Anticorps) and POMC were not the major cause of obesity in the Thai subjects sampled. However, variants in PCSK1 (Montrer PCSK1 Anticorps) did affect cholesterol level, LDL-C level, and waist circumference.
ACTH was readily detected at significantly higher levels in regions of ACTH-secreting adenomas and in normal anterior adenohypophysis compared with non-secreting adenoma and neurohypophysis.
CSF (Montrer CSF2 Anticorps) POMC was higher in lean vs. overweight/obese subjects.
The expression of the genes coding for proopiomelanocortin (POMC), proenkephalin (PENK (Montrer PENK Anticorps)) and prodynorphin (PDYN (Montrer PDYN Anticorps)) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.
The association has been reported between polymorphisms of the CRH (Montrer CRH Anticorps) and POMC genes with economic traits in Korean cattle.
Expression of the hepatic endocannabinoid system and proopiomelanocortin was altered by plane of dietary energy prepartum particularly during the first 2-week postpartum.
Significant associations were observed between POMC c.288C>T with start-of-finishing weight (SOF (Montrer GJA1 Anticorps) WT; P = 0.04), hot carcass weight (HCW; P = 0.02), average fat and grade fat (both P = 0.05), carcass rib-eye area (REA (Montrer PHB2 Anticorps); P = 0.03) and marbling
The polymorphism of POMC gene is associated with the growth traits of Nanyang cattle.
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
, adrenal corticotropic hormone
, adrenocorticotropic hormone
, alpha-melanocyte stimulating hormone
, corticotropin-like intermediary peptide
, melanotropin gamma
, alpha-melanocyte-stimulating hormone
, beta-melanocyte-stimulating hormone
, lipotropin beta
, lipotropin gamma
, melanotropin alpha
, melanotropin beta
, opiomelanocortin prepropeptide
, proopiomelanocortin preproprotein
, proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
, proopiomelanocortin, beta (endorphin, beta)
, proopoimelanocortin, beta (endorphin, beta)
, beta-melanocyte stimulating hormone
, pro-opiomelanocortin a-1
, pro-opiomelanocortin a-2
, pro-opiomelanocortin b-1
, pro-opiomelanocortin b-2