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Aperçu des produits pour anti-DYRK1A (DYRK1A) Anticorps

Full name:
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A Anticorps (DYRK1A)
Chez www.anticorps-enligne.fr sont 126 Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) Anticorps de 19 de différents fournisseurs disponibles. De plus, nous expédions DYRK1A Kits (8) et DYRK1A Protéines (7) et beaucoup plus de produits pour cette protéine. Un total de 153 DYRK1A produits sont actuellement listés.
Synonymes:
2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, DYRK1, DYRK1A, ENSMUSG00000074897, Gm10783, HP86, mmb, MNB, Mnbh, Mp86, MRD7, PSK47

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anti-DYRK1A Anticorps mieux référencés

  1. Human Monoclonal DYRK1A Primary Antibody pour ELISA, WB - ABIN560675 : Aranda, Alvarez, Turró, Laguna, de la Luna: Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A. dans Molecular and cellular biology 2008 (PubMed)
    Show all 38 references for ABIN560675

  2. Human Polyclonal DYRK1A Primary Antibody pour WB - ABIN1881275 : Park, Oh, Yoo, Jung, Song, Lee, Seo, Chung: Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. dans The Journal of biological chemistry 2010 (PubMed)
    Show all 4 references for ABIN1881275

  3. Human Polyclonal DYRK1A Primary Antibody pour EIA, WB - ABIN359711 : Adayev, Chen-Hwang, Murakami, Lee, Bolton, Hwang: Dual-specificity tyrosine phosphorylation-regulated kinase 1A does not require tyrosine phosphorylation for activity in vitro. dans Biochemistry 2007 (PubMed)
    Show all 4 references for ABIN359711

  4. Human Polyclonal DYRK1A Primary Antibody pour EIA, WB - ABIN359712 : Chang, Lin, Yang, Yen, Lai, Chen, Liang, Yu: Increased expression of Dyrk1a in HPV16 immortalized keratinocytes enable evasion of apoptosis. dans International journal of cancer. Journal international du cancer 2007 (PubMed)
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  5. Human Polyclonal DYRK1A Primary Antibody pour EIA, WB - ABIN783434 : Park, Oh, Chung: Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1. dans BMB reports 2009 (PubMed)

Plus d’anticorps contre DYRK1A partenaires d’interaction

Human Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) interaction partners

  1. identified the significant associations of the GBA (Montrer GBA Anticorps) L444P mutation and DYRK1A rs8126696 T allele with the earlier age at onset (AAO) in Parkinson's disease (PD) patients, and the A allele at MS4A6A (Montrer MS4A6A Anticorps) rs610932 with the delayed AAO of PD.

  2. study uncovered a new regulatory mechanism of DYRK1A degradation by SCF (Montrer KITLG Anticorps)(betaTrCP (Montrer BTRC Anticorps)) in HEK293 cell cycle progression.

  3. Identify Dyrk1a as a novel negative regulator of D-cyclin (Montrer PCNA Anticorps)-mediated Rb1 (Montrer RB1 Anticorps)/E2f (Montrer E2F1 Anticorps)-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy.

  4. The deleterious effect of DYRK1A triplication in the formation of the cerebral cortex begins at the onset of neurogenesis, which is relevant to the search for early therapeutic interventions in Down syndrome.

  5. mutations in DYRK1A define a syndromic form of autism spectrum disorder and intellectual disability with neurodevelopmental defects consistent with murine and Drosophila knockout models

  6. Cyclin D1 (Montrer CCND1 Anticorps) Again Caught in the Act: Dyrk1a Links G1 and Neurogenesis in Down Syndrome.

  7. data indicate that host factor DYRK1A plays a role in the regulation of viral transcription and latency.

  8. Inhibition of DYRK1A and GSK3B (Montrer GSK3b Anticorps) induces human beta-cell proliferation

  9. A de novo splice site mutation and a de novo nonsense mutation in DYRK1A were identified in two patients with syndromic intellectual disability.

  10. RNA-seq evidence of biallelic expression of DYRK1A and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of DYRK1A is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB (Montrer WRB Anticorps) differentially methylated region (DMR (Montrer WDR20 Anticorps)) in disomic controls or trisomy (Down syndrome) individuals.

Mouse (Murine) Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) interaction partners

  1. Taken together, these results strongly suggested that DYRK1A bound to CDKL5 (Montrer CDKL5 Anticorps) and phosphorylated it on Ser (Montrer SIGLEC1 Anticorps)-308, thus interfering with its nuclear localization.

  2. Identify Dyrk1a as a novel negative regulator of D-cyclin (Montrer PCNA Anticorps)-mediated Rb1 (Montrer RB1 Anticorps)/E2f (Montrer E2F1 Anticorps)-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy.

  3. study identifies DYRK1A-STAT (Montrer STAT1 Anticorps) as a signaling pathway responsible for the differentiation of neural progenitors into astrocytes, with direct implication for the anomalies in brain development observed in Down syndrome

  4. This study identified decreased neuronal firing rate and deficits in gamma frequency in the prefrontal cortices of transgenic mice overexpressing Dyrk1A.

  5. Increased Dyrk1a gene dosage is a major contributing factor to the abnormal appendicular skeletal phenotype observed in adolescent Ts65Dn Down syndrome mice.

  6. the increased immunostaining of DYRK1A in HIV+ brains without pathology points at dysregulation of DYRK1A as an early event in the neuronal complications of HIV infection.

  7. Our results identify DYRK1A as a physiologically relevant regulator of Treg cell differentiation and suggest a broader role for other DYRK family members in immune homeostasis.

  8. these data suggest that the dosage imbalance of genes other than Dyrk1a is involved in the development of the prenatal bone phenotype in Ts65Dn embryos.

  9. Show the crucial role of the DYRK1A pathway in the regulation of beta cell mass and carbohydrate metabolism in vivo. Activating the DYRK1A pathway could thus represent an innovative way to increase functional beta cell mass.

  10. DYRK1A has a role in lymphopoiesis; Cyclin D3 (Montrer CCND3 Anticorps) protein stability is negatively regulated during exit from the proliferative phases of B and T cell development

Xenopus laevis Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) interaction partners

  1. Dyrk1A positively and selectively modulates p120-catenin (Montrer CTNND1 Anticorps) protein levels, thus having an impact on p120-catenin (Montrer CTNND1 Anticorps) and Kaiso (Montrer ZBTB33 Anticorps) (and canonical Wnt (Montrer WNT2 Anticorps)) gene targets such as siamois and wnt11.

DYRK1A profil antigène

Antigen Summary

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

Alternative names and synonyms associated with DYRK1A

  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) anticorps
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (dyrk1a) anticorps
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a) anticorps
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (Dyrk1a) anticorps
  • 2310043O08Rik anticorps
  • D16Ertd272e anticorps
  • D16Ertd493e anticorps
  • Dyrk anticorps
  • DYRK1 anticorps
  • DYRK1A anticorps
  • ENSMUSG00000074897 anticorps
  • Gm10783 anticorps
  • HP86 anticorps
  • mmb anticorps
  • MNB anticorps
  • Mnbh anticorps
  • Mp86 anticorps
  • MRD7 anticorps
  • PSK47 anticorps

Protein level used designations for DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A , dual specificity tyrosine-phosphorylation-regulated kinase 1A , minibrain , protein kinase minibrain homolog , dual specificity tyrosine-phosphorylation-regulated kinase 1A-like , MNB/DYRK protein kinase , dual specificity YAK1-related kinase , hMNB , mnb protein kinase homolog hp86 , serine/threonine kinase MNB , serine/threonine-specific protein kinase , Dual Specificity Yak1-related kinase , MNBH , RP86 , minibrain protein kinase , Protein kinase minibrain homolog

GENE ID SPECIES
100051707 Equus caballus
458545 Pan troglodytes
693812 Macaca mulatta
779733 Xenopus (Silurana) tropicalis
100019775 Monodelphis domestica
100078677 Ornithorhynchus anatinus
100389032 Callithrix jacchus
100479774 Ailuropoda melanoleuca
100562279 Anolis carolinensis
100601498 Nomascus leucogenys
1859 Homo sapiens
13548 Mus musculus
25255 Rattus norvegicus
100350296 Oryctolagus cuniculus
395233 Gallus gallus
100514684 Sus scrofa
446302 Xenopus laevis
487755 Canis lupus familiaris
532989 Bos taurus
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