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anti-Human DYRK1A Anticorps:
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Human Monoclonal DYRK1A Primary Antibody pour ELISA, WB - ABIN560675
Aranda, Alvarez, Turró, Laguna, de la Luna: Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A. dans Molecular and cellular biology 2008
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Human Polyclonal DYRK1A Primary Antibody pour WB - ABIN1881275
Park, Oh, Yoo, Jung, Song, Lee, Seo, Chung: Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. dans The Journal of biological chemistry 2010
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we suggest that de novo dominant mutations in DYRK1A account for nearly 0.5% of severe developmental disorders due to substantially reduced kinase function
The data described herein provide the first identification of a DYRK1A-mediated site of phosphorylation on GLI1 (Montrer GLI1 Anticorps) within its NLS (Montrer ALDH1A2 Anticorps) and may serve as a valuable mechanism for further understanding Hh signaling modulation.
DYRK1A phosphorylation of NFATc1/alphaA at S261, S278, S403 and S409 interfered with NFATc1 ubiquitination and ubiquitin-proteasome degradation.
These results suggest that TT genotype derived from SNP rs8126696 of DYRK1A gene is a possible risk factor for sporadic Parkinson disease, especially for males in this Chinese Han population.
identified the significant associations of the GBA (Montrer GBA Anticorps) L444P mutation and DYRK1A rs8126696 T allele with the earlier age at onset (AAO) in Parkinson's disease (PD) patients, and the A allele at MS4A6A (Montrer MS4A6A Anticorps) rs610932 with the delayed AAO of PD.
study uncovered a new regulatory mechanism of DYRK1A degradation by SCF (Montrer KITLG Anticorps)(betaTrCP (Montrer BTRC Anticorps)) in HEK293 cell cycle progression.
Identify Dyrk1a as a novel negative regulator of D-cyclin (Montrer PCNA Anticorps)-mediated Rb1 (Montrer RB1 Anticorps)/E2f (Montrer E2F1 Anticorps)-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy.
The deleterious effect of DYRK1A triplication in the formation of the cerebral cortex begins at the onset of neurogenesis, which is relevant to the search for early therapeutic interventions in Down syndrome.
mutations in DYRK1A define a syndromic form of autism spectrum disorder and intellectual disability with neurodevelopmental defects consistent with murine and Drosophila knockout models
Cyclin D1 (Montrer CCND1 Anticorps) Again Caught in the Act: Dyrk1a Links G1 and Neurogenesis in Down Syndrome.
Taken together, these results strongly suggested that DYRK1A bound to CDKL5 (Montrer CDKL5 Anticorps) and phosphorylated it on Ser (Montrer SIGLEC1 Anticorps)-308, thus interfering with its nuclear localization.
study identifies DYRK1A-STAT (Montrer STAT1 Anticorps) as a signaling pathway responsible for the differentiation of neural progenitors into astrocytes, with direct implication for the anomalies in brain development observed in Down syndrome
This study identified decreased neuronal firing rate and deficits in gamma frequency in the prefrontal cortices of transgenic mice overexpressing Dyrk1A.
Increased Dyrk1a gene dosage is a major contributing factor to the abnormal appendicular skeletal phenotype observed in adolescent Ts65Dn Down syndrome mice.
the increased immunostaining of DYRK1A in HIV+ brains without pathology points at dysregulation of DYRK1A as an early event in the neuronal complications of HIV infection.
Our results identify DYRK1A as a physiologically relevant regulator of Treg cell differentiation and suggest a broader role for other DYRK family members in immune homeostasis.
these data suggest that the dosage imbalance of genes other than Dyrk1a is involved in the development of the prenatal bone phenotype in Ts65Dn embryos.
Show the crucial role of the DYRK1A pathway in the regulation of beta cell mass and carbohydrate metabolism in vivo. Activating the DYRK1A pathway could thus represent an innovative way to increase functional beta cell mass.
DYRK1A has a role in lymphopoiesis; Cyclin D3 (Montrer CCND3 Anticorps) protein stability is negatively regulated during exit from the proliferative phases of B and T cell development
Dyrk1A positively and selectively modulates p120-catenin (Montrer CTNND1 Anticorps) protein levels, thus having an impact on p120-catenin (Montrer CTNND1 Anticorps) and Kaiso (Montrer ZBTB33 Anticorps) (and canonical Wnt (Montrer WNT2 Anticorps)) gene targets such as siamois and wnt11.
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
, dual specificity tyrosine-phosphorylation-regulated kinase 1A
, protein kinase minibrain homolog
, dual specificity tyrosine-phosphorylation-regulated kinase 1A-like
, MNB/DYRK protein kinase
, dual specificity YAK1-related kinase
, mnb protein kinase homolog hp86
, serine/threonine kinase MNB
, serine/threonine-specific protein kinase
, Dual Specificity Yak1-related kinase
, minibrain protein kinase
, Protein kinase minibrain homolog