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An association was identified with a genetic variation in CES1 and early-onset capecitabine-related toxicity.
Reduced CES1 expression/activity could promote development of METH-PAH.
These data suggest that CES1 genetic variants and gender are important contributing factors to variability in dabigatran etexilate activation in humans.
some functional CES1 genetic variants (for example, G143E) may impair ACE (Montrer ACE Anticorps) inhibitor activation, and consequently affect therapeutic outcomes of ACEI prodrugs.
HNF4alpha (Montrer HNF4A Anticorps) regulated CES1 expression by directly binding to the proximal promoter of CES1.
We conclude that the -816A>C variant is not associated with interindividual variability in CES1 expression and activity or therapeutic response to ACEI prodrugs
Our study identified CYP2C19 (Montrer CYP2C19 Anticorps)*3 and CES1 rs8192950 as genetic polymorphisms related to recurrent ischemic events in patients with extracranial or intracranial occlusive disease, demonstrating the important roles of CYP2C19 (Montrer CYP2C19 Anticorps) and CES1 in patients treated with clopidogrel
Data suggest oseltamivir activation is associated with an SNP in CES1 (rs71647871, G143E); in liver from donors with genotype 143G/E activation is 40% of that from donors with genotype 143G/G. Hepatic CES1 expression in females is 17.3% higher than in males; oseltamivir activation rate in females is 27.8% higher than in males. (Liver tissues used were obtained from tissue banks located in the United States.)
Study confirms previous reports of the CES1P1-CES1 translocation generating the CES1VAR allele with 11 SNPs in the 5'UTR (Montrer UTS2R Anticorps), exon 1, and intron 1 derived from the CES1P1 sequence with decreased CES1 mRNA expression in the human liver by approximately 30% but normal protein expression.
Study found that CYP2C19 (Montrer CYP2C19 Anticorps)*2, *3, and *8 were associated with lower odds of the primary and secondary endpoints in the symptomatic intracranial atherosclerotic medical group compared with wild-type homozygotes; due to the low incidence of CES1 genetic variation, our study was unable to demonstrate any association between CES1 variations and the primary and secondary endpoints
One novel isoform termed alternative pig liver esterase (Montrer ESD Anticorps) (APLE) was found to hydrolyze methyl-(2R,4E)-5-chloro-2-isopropyl-4-pentenoate in a highly stereoselective manner (E>200).
The objective of this study is to explore the mechanisms that regulate TGH expression in porcine adipocyte and its role in fasting-induced and Isoproterenol-stimulated lipolysis in porcine primary adipocytes.
PMPMEase was purified to apparent homogeneity from porcine liver supernatant.
Loss of CES1 is associated with the susceptibility to high cholesterol diet-induced liver injury.
Hepatic Ces1g/Es-x plays a critical role in limiting hepatic steatosis, very low-density lipoprotein assembly and in augmenting insulin (Montrer INS Anticorps) sensitivity.
Data indicate that organic anion-transporting polypeptides Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces) enzymes, which caused higher conversion of irinotecan to SN-38 in plasma, potentially complicating pharmacokinetic analyses.
Hepatic CES1 plays a critical role in regulating both lipid and carbohydrate metabolism and FXR (Montrer NR1H4 Anticorps)-controlled lipid homeostasis
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.
, carboxyesterase ES-1
, retinyl ester hydrolase
, liver carboxylesterase 1
, neutral retinyl ester hydrolase
, Esterase 2 member of carboxylesterase-cluster 1
, esterase 2, member of carboxylesterase-cluster 1
, carboxylesterase 1
, carboxylesterase 1 (monocyte/macrophage serine esterase 1)
, acyl coenzyme A:cholesterol acyltransferase
, acyl-coenzyme A:cholesterol acyltransferase
, brain carboxylesterase hBr1
, carboxylesterase 2 (liver)
, cholesteryl ester hydrolase
, cocaine carboxylesterase
, human monocyte/macrophage serine esterase 1
, methylumbelliferyl-acetate deacetylase 1
, monocyte/macrophage serine esterase
, serine esterase 1
, triacylglycerol hydrolase
, carboxylesterase D1
, alternative pig liver esterase
, liver carboxylesterase
, prenylated methylated protein methyl esterase
, carboxylesterase 1-like
, carboxyesterase ES-3
, esterase 22
, liver carboxylesterase 3
, pI 5.5 esterase