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our results demonstrated that miR (Montrer MLXIP Kits ELISA)-30a may modulate the radiosensitivity of non-small cell lung cancer (NSCLC) through reducing the function of ATF1 in phosphorylation of ATM (Montrer ATM Kits ELISA) and have potential therapeutic value.
genetic association studies in a population in China: Data suggest that an SNP in ATF1 (rs11169571) is associated with essential hypertension in the population studied; altered binding of microRNA-1283 appears to be involved.
EWSR1 (Montrer EWSR1 Kits ELISA)-ATF1 fusion gene was found in hyalinizing clear cell carcinoma
Heme activates the ATF1 pathway in human macrophages via AMPK (Montrer PRKAA1 Kits ELISA), and that a similar response occurs after treatment of cells with metformin.
ATF1 protein expression was significantly lower in colorectal cancer tissues than corresponding normal tissues; patients with higher ATF1 expression levels have a significantly higher survival rate than those with lower expression
Review: discuss clinicopathologic and molecular features of group of neoplasms unified by the presence of EWSR1 (Montrer EWSR1 Kits ELISA)-CREB1 (Montrer CREB1 Kits ELISA) and EWSR1 (Montrer EWSR1 Kits ELISA)-ATF1 genetic fusions.
ATF-1 mediates HO-1 (Montrer HMOX1 Kits ELISA) induction by heme and drives macrophage adaptation to intraplaque hemorrhage.
Hyalinizing clear-cell carcinoma is a unique low-grade salivary carcinoma that consistently harbors EWSR1 (Montrer EWSR1 Kits ELISA)-ATF1 fusion.
Differential expression of CREB (Montrer CREB1 Kits ELISA)/ATF transcription factors could be observed on neurogenic induction, pointing to a decisive role of the cAMP-CREB (Montrer CREB1 Kits ELISA)/ATF system.
An increase in phosphorylation of CREB (Montrer CREB1 Kits ELISA)/ATF-1 in human dental pulp cells was noted after exposure to PGF2alpha for 1-20 min,with a maximal induction at 10 min.
the HSF1 (Montrer HSF1 Kits ELISA) complex, including BRG1 (Montrer SMARCA4 Kits ELISA) and lysine acetyltransferases p300 (Montrer NOTCH1 Kits ELISA) and CREB-binding protein (CBP (Montrer CREBBP Kits ELISA)), is formed in a manner dependent on the phosphorylation of ATF1
conclude that HO-1 (Montrer HMOX1 Kits ELISA) regulates DC maturation and function by modulating the p38 MAPK (Montrer MAPK14 Kits ELISA)-CREB (Montrer CREB1 Kits ELISA)/ATF1 signaling axis
Dehydroepiandrosterone sulfate (DHEAS (Montrer SULT2A1 Kits ELISA))-induced signaling is mediated through interaction with a membrane-bound G-protein-coupled receptor (Montrer GPR34 Kits ELISA), since silencing of Gnalpha11 leads to the abolition of the DHEAS (Montrer SULT2A1 Kits ELISA)-induced stimulation of Erk1/2 (Montrer MAPK1/3 Kits ELISA), ATF-1, and CREB (Montrer CREB1 Kits ELISA).
indicate that dysregulation of p38 MAPK (Montrer MAPK14 Kits ELISA)-CREB (Montrer CREB1 Kits ELISA)/ATF1 signaling axis underlies the altered function and phenotype in Nrf2 (Montrer NFE2L2 Kits ELISA)-deficient DCs
Forced expression of EWS/ATF1 resulted in the development of EWS/ATF1-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1-driven transformation.
miR (Montrer MLXIP Kits ELISA)-34c functions, at least partially, by targeting the ATF1 gene in germ cell apoptosis, providing a novel mechanism with involvement of miRNA in the regulation of germ cell apoptosis.
ATF1 is a novel substrate of RSK2 (Montrer RPS6KA3 Kits ELISA) and that RSK2 (Montrer RPS6KA3 Kits ELISA)-ATF1 signaling plays an important role in EGF (Montrer EGF Kits ELISA)-induced neoplastic cell transformation.
study demonstrates a role for trophic signaling and constitutive activation of activating transcription factor 1(Atf1) and cAMP response element-binding protein (CREB (Montrer CREB Kits ELISA)) at the time of zygotic genome activation
MSK1 (Montrer RPS6KA5 Kits ELISA) and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB (Montrer CREB1 Kits ELISA) and ATF1 in fibroblasts.
phosphorylation by the ERK MAPK (Montrer MAPK1 Kits ELISA) pathway is required for epidermal growth factor (Montrer EGF Kits ELISA)-induced c-jun (Montrer JUN Kits ELISA) expression
Data indicate increasing expression for CREB (Montrer CREB1 Kits ELISA), ATF1, and ATF3 (Montrer ATF3 Kits ELISA) during gastrulation.
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.
activating transcription factor 1
, cyclic AMP-dependent transcription factor ATF-1
, cAMP-dependent transcription factor ATF-1