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These observations provide consistent evidence that genetic variants at the NCOA7 locus may confer a reduced risk of breast cancer.
ERAP140 may represent a distinct class of nuclear receptor coactivators. ERAP140 is recruited by estrogen-bound ER alpha (Montrer ESR1 Protéines) to the promoter region of endogenous ER alpha (Montrer ESR1 Protéines) target genes in a cyclic pattern similar to that of other coactivators.
NCOA7 encodes the nuclear counterpart of the mitochondrial OXR1 (Montrer OXR1 Protéines) protein and in mammalian cells it may reduce the oxidative by-products of estrogen metabolite-mediated DNA damage.
present findings indicate that ERAP140/Nbla10993 plays an important role in the regulation of ATRA-mediated neuronal differentiation, and is a novel member of prognostic indicators for neuroblastoma (Montrer ARHGEF16 Protéines).
ERAP 140 interacts with ER beta (Montrer ESR2 Protéines) and its interaction decreases but its expression increases with age in mouse cerebral cortex.
Enhances the transcriptional activities of several nuclear receptors (By similarity).
nuclear receptor coactivator 7
, NCOA7 short isoform
, 140 kDa estrogen receptor-associated protein
, TBC/LysM-associated domain containing 4
, estrogen nuclear receptor coactivator 1
, estrogen receptor associated protein 140 kDa
, putative protein product of Nbla00052
, putative protein product of Nbla10993