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Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis
Loss of NCOR1 is associated with Thyroid Cancer.
These studies support a model in which NCOR1/2 mediates direct Retinoic acid-dependent repression of Fgf8 (Montrer FGF8 Kits ELISA) in caudal (Montrer CAD Kits ELISA) progenitors in order to control somitogenesis.
demonstrate that the binding of HDAC3 (Montrer HDAC3 Kits ELISA) to IR nGREs in vivo is mediated through interaction with SMRT/NCoR1
GR SUMOylation site is mandatory for the formation of a GR-small ubiquitin-related modifiers (SUMOs)-SMRT/NCoR1-HDAC3 (Montrer HDAC3 Kits ELISA) repressing complex, which is indispensable for NF-kappaB (Montrer NFKB1 Kits ELISA)/AP1 (Montrer JUN Kits ELISA)-mediated GC-induced tethered indirect transrepression in vitro
dexamethasone, a powerful regulator of metabolism and of adipocyte differentiation, confers this change in NCoR mRNA splicing in cultured adipocytes.
Phosphorylation-mediated recruitment switch of NCoR1 between nuclear receptor subsets provides a mechanism by which corepressors can selectively modulate liver energy metabolism during the fasting-feeding transition
NCOR1 protein levels were significantly reduced.
corepressor specificity exists in vivo and that nuclear receptor corepressor1 is the principal regulator of thyroid hormone (Montrer PTH Kits ELISA) action
NCOR1 interacts with Rev-Erbalpha (Montrer NR1D1 Kits ELISA) to regulate circadian expression of Tshb (Montrer TSHB Kits ELISA) mRNA independent of thyroid hormone (Montrer PTH Kits ELISA).
these data indicate that interactions between NCoR1 and TR control a specific pathway involved in regulation of cholesterol metabolism and clearance.
USP44 (Montrer USP44 Kits ELISA) contributes to N-CoR functions in regulating gene expression and is required for efficient invasiveness of triple-negative breast cancer cells.
PDCD2 (Montrer PDCD2 Kits ELISA) and NCoR1 may act as tumor suppressors in Gastrointestinal stromal tumors cells through the Smad (Montrer SMAD1 Kits ELISA) signaling pathway.
Data suggest that complexes of HDAC3-H1.3 with NCOR1 and NCOR2/SMRT accumulate on chromatin in synchronized HeLa cells in late G2 phase and mitosis; deacetylation activity of HDAC3 is activated via phosphorylation of Ser-424 by CK2 only in mitosis.
NCoR depletion enhances cancer cell invasion and increases tumor growth and metastatic potential.
loss of nuclear NCoR results in upregulation of a specific cancer-related genetic signature, and is significantly associated with malignant melanoma progression.
The co-localization of AML1 (Montrer RUNX1 Kits ELISA)-ETO (Montrer RUNX1T1 Kits ELISA) with the N-CoR co-repressor to be primarily on genomic regions distal to transcriptional start sites. (NcoR1)
Data suggest that direct interactions of HLCS (Montrer HLCS Kits ELISA) (holocarboxylase synthetase) with NCOR1 (nuclear receptor corepressor 1) and HDAC1 (histone deacetylase 1 (Montrer HDAC1 Kits ELISA)) contribute toward transcriptional repression of repeats, presumably increasing genome stability.
Low NCoR expression is associated with glioblastoma.
Site directed mutagenic analysis of N-CoR identified serine 1450 as the crucial residue whose phosphorylation by Akt (Montrer AKT1 Kits ELISA) was essential for the misfolding and loss of N-CoR protein.
Study shows that NCoR1 is a key target of proteolysis and physically interacts with the transcription factor CREB (Montrer CREB1 Kits ELISA), the genome-wide map described here ties proteolysis in mammalian cells to active enhancers and to promoters of specific gene families.
Data provide in vivo evidence for targeted recruitment of N-CoR/SMRT-TBLR1 (Montrer TBL1XR1 Kits ELISA) complexes by unliganded thyroid hormone (Montrer PTH Kits ELISA) receptors in transcriptional repression during vertebrate development
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
nuclear receptor corepressor 1
, nuclear receptor co-repressor 1
, retinoid X receptor interacting protein 13
, retinoid X receptor-interacting protein 13
, N-Cor/SMRT corepressor Rip13
, N-Cor/SMRT corepressor, Rip13
, thyroid hormone- and retinoic acid receptor-associated corepressor 1