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Results show reduced Tob2 expression in primary hepatocellular Carcinoma cells (HCC (Montrer FAM126A Kits ELISA)) and that dysregulation of miR (Montrer MLXIP Kits ELISA)-362 and Tob2 may contribute to HCC (Montrer FAM126A Kits ELISA) malignancy.
The antiproliferative and the mRNA deadenylation/decay-promoting effects of TOB1 and TOB2 proteins are linked.
study identifies miR-378-TOB2-cyclin D1 as a functional module to mediate the cross talk between Myc and Ras signaling in cellular transformation
TNFalpha (Montrer TNF Kits ELISA) is able to transactivate ErbB-2 (Montrer ERBB2 Kits ELISA) and use it as an obligatory downstream signaling molecule in the generation of mitogenic signals.
Haploinsufficiency of the MLL (Montrer MLL Kits ELISA) and TOB2 genes in lymphoid malignancy.
Antiproliferative proteins of the BTG/Tob (Montrer TDO2 Kits ELISA) family are degraded by the ubiquitin-proteasome system. the C-terminal regions are necessary and sufficient to control the stabilities of BTG1 (Montrer BTG1 Kits ELISA), BTG2 (Montrer BTG2 Kits ELISA), Tob (Montrer TDO2 Kits ELISA), and Tob2 proteins.
Tob1(-/-), Tob2(-/-), and Tob1/2 double knockout (DKO, Tob1(-/-) & Tob2(-/-)) embryonic stem cells (ESCs (Montrer NR2E3 Kits ELISA)) grew faster than wild type (WT) ESCs (Montrer NR2E3 Kits ELISA) without losing pluripotency.
miR (Montrer MLXIP Kits ELISA)-322 and its target protein Tob2 modulate Osx (Montrer SP7 Kits ELISA) mRNA stability
Tob2 protein suppresses PPARgamma2 (Montrer PPARG Kits ELISA) transcription by inhibiting BMP2 (Montrer BMP2 Kits ELISA)-induced Smad1 (Montrer SMAD1 Kits ELISA)/5 phosphorylation through its interaction with Smad6 (Montrer SMAD6 Kits ELISA) and by sequestering C/EBPalpha (Montrer CEBPA Kits ELISA) from the PPARgamma2 (Montrer PPARG Kits ELISA) promoter.
Tob2 negatively regulates formation of osteoclasts by suppressing RANKL (Montrer TNFSF11 Kits ELISA) expression through its interaction with vitamin D receptor (Montrer VDR Kits ELISA)
TOB2 belongs to the TOB (see TOB1\; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.
, transducer of ERBB2, 2
, protein Tob4
, transducer of erbB-2 2