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Nurr1 was induced during intestinal regeneration after I/R injury. Nurr1 promoted proliferation of intestinal epithelial cells after H/R injury. Nurr1 inhibited p21 (Montrer CDKN1A Protéines) expression in a p53 (Montrer TP53 Protéines)-independent manner. Nurr1 inhibited p21 (Montrer CDKN1A Protéines) gene transcription by binding to p21 (Montrer CDKN1A Protéines) promoter directly.
Our findings of a de novo deletion of NR4A2 in an individual with mild intellectual disability and prominent speech and language impairment provides further evidence for NR4A2 haploinsufficiency being causative for neurodevelopmental and particularly language phenotypes
Findings support that Notch1 (Montrer NOTCH1 Protéines)/NR4A2 co-regulate HCC (Montrer FAM126A Protéines) cell functions by playing oncogenic roles and regulating the associated downstream signaling pathways.
NR4A sub-family of nuclear orphan receptors (Nor-1 (Montrer NR4A3 Protéines), Nurr-1 and Nur-77 (Montrer NR4A1 Protéines)) may have a role in trophoblastic cell differentiation.
this study shows over-expression of NR4A2 mRNA in peripheral CD4 (Montrer CD4 Protéines)+ T cells of Sjogren's syndrome patients
NR4A2 and NR4A3 (Montrer NR4A3 Protéines) are components of a downstream transcriptional response to PKA activation in the neutrophil, and that they positively regulate neutrophil survival and homeostasis.
Study found a marked down-regulated gene expression of the NR4A subfamily (NR4A1 (Montrer NR4A1 Protéines), NR4A2, and NR4A3 (Montrer NR4A3 Protéines)) obtained from Parkinson's disease patients, but only a NR4A1 (Montrer NR4A1 Protéines) decrease in Alzheimer's disease patients compared to healthy controls. This study reports that the entire NR4A subfamily and not only NR4A2 could be systemically involved in Parkinson's disease.
show that unsaturated fatty acids also interact with the Nurr1 LBD, and solution NMR spectroscopy reveals the binding epitope of DHA at its putative ligand-binding pocket
NURR1 is an essential transcription factor for the differentiation, maturation, and maintenance of midbrain dopaminergic neurons.
Nurr1 overexpression exerts neuroprotective and anti-inflammatory roles via down-regulating CCL2 (Montrer CCL2 Protéines) in both in vivo and in vitro Parkinson's disease models, contributing to developing mechanism-based and neuroprotective strategies against PD
The Nurr1 expression may play a significant role in regulating inflammation in the brain.
Knockdown of DJ-1 (Montrer PARK7 Protéines) attenuates Nurr1 activity.
Overexpression of Nurr1 and Pitx3 (Montrer PITX3 Protéines) in iPSCs could efficiently program induced pluripotent stem cells into functional dopaminergic-like neurons. This finding may have an impact on future stem cell therapy of Parkinson's disease.
Overexpression and knockdown of Nr4a2 demonstrated that Nr4a2 orchestrates the expression of immunoregulatory genes, hence inducing a tolerogenic phenotype in bone marrow derived dendritic cells (DC) in mice. The findings suggest a previously unidentified role for Nr4a2 as a regulator of dendritic cell tolerogenicity and demonstrate its potential as therapeutic target in DC-associated pathophysiologies.
Nurr1 defect induces early experimental autoimmune encephalomyelitis (EAE) onset and increases inflammatory infiltrates in spinal cord suggesting a Nurr1 role in the early phase of EAE
Nr4a2 factor plays crucial role regulatory T cells, mediating the two defining characteristics of regulatory T cells: stability of cell lineage and immunosuppressive functions.
Results indicate that Nurr1 overexpression in olfactory bulb stem cells induces the formation of two populations of mature dopaminergic neurons with features of the ventral mesencephalon or of the olfactory bulb
Nurr1 +/- genotype predisposes mice to T. gondii-induced alterations in behaviors that involve dopamine neurotransmission
The authors show herein that Nurr1 and Foxa2 (Montrer FOXA2 Protéines) interact to protect midbrain dopaminergic neurons against various toxic insults, but their expression is lost during aging and degenerative processes.
Because the phosphorylation site mutants of NR4A2 cannot rescue the cell death-promoting activity, ASK1 (Montrer MAP3K5 Protéines)-p38 (Montrer CRK Protéines) pathway-dependent phosphorylation and subsequent cytoplasmic translocation of NR4A2 may be required for oxidative stress-induced (Montrer SQSTM1 Protéines) cell death.
data indicate a conserved evolutionary role of Nr4a2 proteins in specification of the neurotransmitter phenotype
Results shed new light on NR4A2 function in the dopamine differentiation pathway, and stress the effect of dopamine dysregulation on the control of locomotor activity.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
nuclear receptor subfamily 4, group A, member 2
, nuclear receptor
, nuclear receptor related 1
, nuclear receptor subfamily 4 group A member 2
, Nuclear receptor subfamily 4 group A member 2
, NGFI-B/nur77 beta-type transcription factor homolog
, T-cell nuclear receptor NOT
, immediate-early response protein NOT
, intermediate-early receptor protein
, nur related protein-1, human homolog of
, orphan nuclear receptor NR4A2
, orphan nuclear receptor NURR1
, transcriptionally inducible nuclear receptor related 1
, transcriptionally-inducible nuclear receptor
, NUR-related factor 1
, nuclear orphan receptor HZF-3
, nuclear receptor subfamily 4 group A member 2 variant TINUR
, nuclear receptor subfamily 4 group A member 2 variant NURR1a
, nuclear receptor subfamily 4 group A member 2 variant NURR1b
, nuclear receptor subfamily 4 group A member 2 variant NURR1c
, nuclear receptor subfamily 4 group A member 2 variant NURR2c
, nur related protein 1
, regenerating liver nuclear receptor 1
, nerve growth factor 1b
, neural orphan nuclear receptor