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anti-Mouse (Murine) Retinoid X Receptor alpha Anticorps:
anti-Rat (Rattus) Retinoid X Receptor alpha Anticorps:
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Human Polyclonal Retinoid X Receptor alpha Primary Antibody pour ELISA, WB - ABIN2476395
Stewart, Tuffnell: Cloning the cDNA for horse growth hormone and expression in Escherichia coli. dans Journal of molecular endocrinology 1991
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Human Monoclonal Retinoid X Receptor alpha Primary Antibody pour EMSA, IP - ABIN2668713
Subbarayan, Mark, Messadeq, Rustin, Chambon, Kastner: RXRalpha overexpression in cardiomyocytes causes dilated cardiomyopathy but fails to rescue myocardial hypoplasia in RXRalpha-null fetuses. dans The Journal of clinical investigation 2000
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Human Polyclonal Retinoid X Receptor alpha Primary Antibody pour ELISA, WB - ABIN250299
Claudel, Leibowitz, Fiévet, Tailleux, Wagner, Repa, Torpier, Lobaccaro, Paterniti, Mangelsdorf, Heyman, Auwerx: Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor. dans Proceedings of the National Academy of Sciences of the United States of America 2001
The study shows that FXR (Montrer NR1H4 Anticorps)/RXR regulates Chop (Montrer DDIT3 Anticorps) expression in a mouse model of steatohepatitis, providing novel insights into pathogenesis of this disorder.
These results suggest a mechanism to establish RXR therapeutic targets with significance in neurodegeneration.
The optimal PPARalpha (Montrer PPARA Anticorps)/RXRalpha heterodimer binding sequence was WAWVTRGGBBAHRGKTYA. The single nucleotide substitution, which reduces binding of RXRalpha to DNA, attenuated PPARalpha (Montrer PPARA Anticorps)-induced transcriptional activation, but this is not always true for PPARalpha (Montrer PPARA Anticorps).
A change in the heterodimeric partner of Peroxisome Proliferator Activated Receptor-alpha (Montrer PPARA Anticorps) from retinoid X receptor (Montrer RXRB Anticorps) to Silent information regulator 1 is responsible for the impaired fatty acid metabolism and cardiac dysfunction in the failing heart.
interaction of Wnt and RXR-alpha pathways in hepatocyte development and hepatocellular carcinoma
a crucial role of RXRa in suppression of UVB-induced melanomas in the context of driver mutations such as activated CDK4 (Montrer CDK4 Anticorps)(R24C/R24C) or oncogenic NRAS (Montrer NRAS Anticorps)(Q61K) and altered expression of p53 (Montrer TP53 Anticorps) and PTEN (Montrer PTEN Anticorps)
This uncovered a novel RXR-dependent innate immune regulatory pathway, suggesting that downregulation of RXR expression or RXR antagonist treatment benefits host antiviral response, whereas RXR agonist treatment may increase risk of viral infections.
Data suggest that retinoic acid and GM-CSF (Montrer CSF2 Anticorps)-induced retinal dehydrogenase 2 (RALDH2 (Montrer ALDH1A2 Anticorps)) expression in dendritic cells requires cooperative binding of transcription factor Sp1 (Montrer SP1 Anticorps) via the RA receptor/retinoid X receptor (Montrer RXRB Anticorps) complex to the Aldh1a2 (Montrer ALDH1A1 Anticorps) promoter.
The expression and binding of RXRalpha to CYP3A genes in liver was sex-dependent and regulated by growth hormone secretion.
The depletion of retinoic acid and the inhibition of RXRalpha function in hepatic tumors involve more complex mechanisms besides the activation of RAS/ERK (Montrer EPHB2 Anticorps) pathway.
Immune cell-infiltration is controlled by activated peroxisome proliferator activated receptor gamma (PPARgamma (Montrer PPARG Anticorps))/retinoid X receptor alpha (RXRalpha) that inhibits expression/secretion of inflammatory cytokines.
Data suggest that the binding of Z-10 to RXRalpha inhibited the interaction of RXRalpha with PML (Montrer PML Anticorps)-RARalpha (Montrer RARA Anticorps), leading to Z-10's selective induction of PML (Montrer PML Anticorps)-RARalpha (Montrer RARA Anticorps) degradation.
This suggests that hRXRalpha phosphorylation significantly disrupts its nuclear localization, interaction with VDR, intra-nuclear trafficking, and binding to chromatin of the hVDR-hRXR complex.
the expression of CAMP, vitamin D receptor (VDR), and the retinoid X receptor (RXR) isoforms in human skin and gingival tissue biopsies and investigated the signaling pathways involved in 1alpha,25-dihydroxyvitamin D3-induced upregulation of CAMP.
data show that RXRalpha expression is increased in miscarriage in endometrial glands and correlation analysis showed that negative correlation between RXRalpha and PPARgamma (Montrer PPARG Anticorps) disappears in miscarriage. This shift is supposable responsible for the loss of regular function in trophoblast and embryonic tissue.
IL-1beta (Montrer IL1B Anticorps) upregulated RXRalpha through activation of NF-kappaB (Montrer NFKB1 Anticorps) signaling.
RXRA rs10776909 allele T is specifically involved in the pathogenesis of ChGN (Montrer CSGALNACT1 Anticorps). This risk allele may be also associated with worse clinical course of ChGN (Montrer CSGALNACT1 Anticorps).
Results suggest that retinoid X receptor (Montrer RXRB Anticorps) (RXR) activation protects retinal pigment epithelium (RPE (Montrer RPE Anticorps)) cells from oxidative stress-induced (Montrer SQSTM1 Anticorps) apoptosis.
Data show that pregnane X receptor/retinoid X receptor PXR/RXR-[alpha], RXR-[beta], or RXR-[gamma] expression was noted in 9 (16.4%), 9 (16.4%), and 10 (18.2%) pancreatic adenocarcinoma cases, respectively.
Retinoid X receptor alpha plays an important role in proliferation of cholangiocarcinoma
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators.
retinoid X receptor, alpha
, retinoid X receptor alpha
, RXR alpha 1
, nuclear receptor subfamily 2 group B member 1
, retinoic acid receptor RXR-alpha
, retinoid X nuclear receptor alpha
, retinoic acid receptor
, retinoid x receptor alpha
, retinoid X receptor alpha protein
, nuclear receptor subfamily 2 group B member 2-A
, retinoic acid receptor RXR-beta-A
, retinoid X receptor beta-A
, retinoid receptor-epsilon
, retinoid x receptor, epsilon