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Apoptose

L'apoptose est un processus très réglé permettant à un organisme d'éliminer de façon organisée les cellules qui ne sont plus utiles. Il est initié soit par une catégorie spécifique de récepteurs de mort soit par des facteurs intrinsèques tels que des dommages à l'ADN. L'apoptose est principalement due à des protéases de caspase et régulée également par les protéines Bcl-2 et inhibitrices. La dérégulation de cette mort programmée de cellules est souvent associée au cancer.

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Autophagy

Autophagy is the regulated, self-degradative process of the cell that disassembles unnecessary or dysfunctional components. The lysosomal pathway is evolutionarily conserved and initiates engulfment, degradation and recycling of cellular contents including long-lived proteins and organelles thus promoting cell survival.

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Cycle Cellulaire

Cell division unfolds in four stages - G1, S, G2, and M phase – depending on a number of internal or external signals. Progression through the different phases is driven by cyclin dependent kinases (CDK) and their activators, the cyclins. Additionally, their activity is further modulated by CDK inhibitors. Tight control of the cell cycle is essential to maintain proper cell homeostasis.

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Dynamique des Microtubules

Les microtubules sont des routes intracellulaires structurelles et fonctionnelles hautement dynamiques. Le terme cytosquelette évoque l'image d'une structure rigide, immuable et permanente. En réalité, le cytosquelette est un réseau interconnecté fortement dynamique constitué de trois différents composants principaux : les microtubules...

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Réparation de l'ADN

Tout organisme est doté de différents mécanismes de réparation de l’ADN assurant l’intégrité de l’information génétique contenue dans le noyau de chaque cellule. L’importance cruciale que revêt le maintien de l’intégrité de l’ADN se reflète dans la multitude de voies de réparation de l’ADN et dans la diversité des protéines impliquées dans ces processus.

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Signalisation Hedgehog

La cascade de signaux Hedgehog (Hh) est l’un des éléments les plus importants de nombreux processus de développement. Ce sont les produits génétiques des gènes ciblés qui déterminent le caractère souche des cellules, leur renouvellement, leur survie et leur migration. Un dérèglement des protéines Hh et des effecteurs en aval joue un rôle important dans la progression des cancers.

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Signalisation MAPK

La phosphorylation est le processus réversible d'addition d'un groupe phosphate à un résidu spécifique d'acide aminé sur une molécule. Sur le plan fonctionnel, la phosphorylation agit comme un simple commutateur moléculaire qui peut activer, désactiver ou moduler la fonction d'une protéine.

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Signalisation NF-kappaB

Les NF-kappaB (facteurs nucléaires améliorateurs de chaîne légère kappa de cellules B activées) sont un groupe de facteurs de transcription homo- ou hétérodimétriques qui jouent un rôle capital dans un réseau de nombreuses voies de transduction de signaux...

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Signalisation Notch

La voie de signalisation Notch, bien conservée, est unique en son genre car le récepteur Notch et la plupart de ses ligands respectifs (canoniquement ceux de la famille DSL ou Delta/Serrate/LAG-2) sont des protéines transmembranaires fixées à la surface de la cellule. ...

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Signalisation p53

p53 est l'un des plus importants suppresseurs de tumeurs, appelé souvent « le Gardien de l'intégrité du génome ». On retrouve des mutations du p53 ou de certaines parties de son circuit de régulation dans presque tous les cancers, ce qui montre son importance. Il conserve la stabilité du génome en prévenant les mutations causées...

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Signalisation PI3K-Akt

La transduction de signal PI3K/Akt a un rôle charnière dans l’homéostasie cellulaire, le développement neurologique, le métabolisme et d’autres processus. Elle régule différents aspects du développement cellulaire comme l’apoptose, la progression du cycle cellulaire et la différenciation cellulaire. Le régulateur principal du signal PI3K/Akt est Akt/PKB, une famille de trois protéines kinases...

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Signalisation RTK

Les récepteurs tyrosine kinase (RTK) sont des kinases liées à la membrane qui sont activées lorsque les ligands spécifiques aux récepteurs se lient. Ils constituent la plus grande classe de récepteurs de membrane qui provoquent des cascades de signalisation via leur activité enzymatique inhérente.

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Signalisation TLR

Toll-like receptors play an essential in the innate immune response against various pathogens such as viruses, bacteria, and fungi. TLRs elicit one of two conserved inflammatory pathways: either the TRIF- or the MyD88 dependent pathway. Besides, TLR signaling also induces dendritic cell maturation and the adaptive immune response.

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Signalisation WNT

Wnts are a class of evolutionarily-conserved, lipid-modified glycoproteins that play a pivotal role in development and homeostasis through a number of different paracrine...

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Signalistation JAK/STAT

La signalisation JAK-STAT est hautement conservée chez les vertébrés et même d’autres métazoaires. L’association de kinases activées par les récepteurs et de facteurs de...

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Système du Complément

Le système du complément fait partie du système immunitaire inné, et il joue un rôle essentiel dans la défense...

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ACE Inhibitor Pathway

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Activated T Cell Proliferation

Browse our antibodies, ELISA kits and proteins related to activated T cell proliferation.

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Activation of Innate immune Response

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AMPK Signaling

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Asymmetric Protein Localization

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Brown Fat Cell Differentiation

Browse our antibodies, ELISA kits and proteins related to brown fat cell differentiation.

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C21-Steroid Hormone Metabolic Process

Browse our antibodies, ELISA kits and proteins related to C21-steroid hormone metabolic process.

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cAMP Metabolic Process

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Carbohydrate Homeostasis

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Caspase Cascade in Apoptosis

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Cell RedoxHomeostasis

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Cell-Cell Junction Organization

Browse our antibodies, ELISA kits and proteins related to cell-cell junction organization.

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Cellular Glucan Metabolic Process

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Cellular Response to Molecule of Bacterial Origin

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Chromatin Binding

Browse our antibodies, ELISA kits and proteins related to chromatin binding.

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CXCR4-mediated Signaling Events

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Dicarboxylic Acid Transport

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DNA Replication

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Dopaminergic Neurogenesis

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EGFR Downregulation

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EGFR Signaling Pathway

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Embryonic Body Morphogenesis

Browse our antibodies, ELISA kits and proteins related to embryonic body morphogenesis.

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ER-Nucleus Signaling

Browse our antibodies, ELISA kits and proteins related to the ER-nucleus signaling pathway.

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Fc-epsilon Receptor Signaling Pathway

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Feeding Behaviour

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G-protein mediated Events

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Glycosaminoglycan Metabolic Process

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Growth Factor Binding

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Hepatitis C

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Hormone Activity

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Hormone Transport

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Inositol Metabolic Process

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Integrin Complex

Browse our antibodies, ELISA kits and proteins related to the integrin complex.

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Interaction of EGFR with phospholipase C-gamma

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Interferon-gamma Pathway

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Intracellular Steroid Hormone Receptor Signaling Pathway

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M Phase

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Maintenance of Protein Location

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Metabolism of Steroid Hormones and Vitamin D

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Methionine Biosynthetic Process

Browse our antibodies, ELISA kits and proteins related to the methionine biosynthetic process.

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Mitotic G1-G1/S Phases

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Monocarboxylic Acid Catabolic Process

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Myometrial Relaxation and Contraction

Browse our antibodies, ELISA kits and proteins related to myometrial relaxation and contraction pathways.

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Negative Regulation of Hormone Secretion

Browse our antibodies, ELISA kits and proteins related to negative regulation of hormone secretion.

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Negative Regulation of intrinsic apoptotic Signaling

Browse our antibodies, ELISA kits and proteins related to negative regulation of intrinsic apoptotic signaling.

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Negative Regulation of Transporter Activity

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Neurotrophin Signaling Pathway

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Nuclear Hormone Receptor Binding

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Nuclear Receptor Transcription Pathway

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Nucleotide Phosphorylation

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Peptide Hormone Metabolism

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Photoperiodism

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Phototransduction

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Platelet-derived growth Factor Receptor Signaling

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Positive Regulation of Endopeptidase Activity

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Positive Regulation of fat Cell Differentiation

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Positive Regulation of Immune Effector Process

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Positive Regulation of Peptide Hormone Secretion

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Positive Regulation of Response to DNA Damage Stimulus

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Production of Molecular Mediator of Immune Response

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Protein targeting to Nucleus

Browse our antibodies, ELISA kits and proteins related to the protein targeting to nucleus.

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Proton Transport

Browse our antibodies, ELISA kits and proteins related to proton transportation.

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Regulation of Actin Filament Polymerization

Browse our antibodies, ELISA kits and proteins related to the regulation of actin filament polymerization.

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Regulation of Carbohydrate Metabolic Process

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Regulation of Cell Size

Browse our antibodies, ELISA kits and proteins related to the regulation of cell size.

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Regulation of G-Protein Coupled Receptor Protein Signaling

Browse our antibodies, ELISA kits and proteins related to the regulation of G-protein coupled receptor protein signaling.

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Regulation of Hormone Biosynthetic Process

Browse our antibodies, ELISA kits and proteins related to the regulation of hormone biosynthetic processes.

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Regulation of Hormone Metabolic Process

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Regulation of Intracellular Steroid Hormone Receptor Signaling

Browse our antibodies, ELISA kits and proteins related to regulation of intracellular steroid hormone receptor signaling.

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Regulation of Leukocyte Mediated Immunity

Browse our antibodies, ELISA kits and proteins related to regulation of leukocyte mediated immunity.

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Regulation of Lipid Metabolism by PPARalpha

Browse our antibodies, ELISA kits and proteins related to the Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

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Regulation of long-term Neuronal Synaptic Plasticity

Browse our antibodies, ELISA kits and proteins related to regulation of long-term neuronal synaptic plasticity.

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Regulation of Muscle Cell Differentiation

Browse our antibodies, ELISA kits and proteins related to regulation of muscle cell differentiation.

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Regulation of Systemic Arterial Blood Pressure by Hormones

Browse our antibodies, ELISA kits and proteins related to the regulation of systemic arterial blood pressure by hormones.

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Regulatory RNA Pathways

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Response to Growth Hormone Stimulus

Browse our antibodies, ELISA kits and proteins related to response to growth hormone stimulus.

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Response to Water Deprivation

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Retinoic Acid Receptor Signaling Pathway

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Ribonucleoprotein Complex Subunit Organization

Browse our antibodies, ELISA kits and proteins related to the ribonucleoprotein complex subunit organization.

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Ribonucleoside Biosynthetic Process

Browse our antibodies, ELISA kits and proteins related to ribonucleoside biosynthetic process.

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Ribosome Assembly

Browse our antibodies, ELISA kits and proteins related to ribosome assembly.

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Sensory Perception of Sound

Browse our antibodies, ELISA kits and proteins related to the sensory perception of sound.

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Signaling Events mediated by VEGFR1 and VEGFR2

Browse our antibodies, ELISA kits and proteins related to signaling events mediated by VEGFR1 and VEGFR2.

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Signaling of Hepatocyte Growth Factor Receptor

Browse our antibodies, ELISA kits and proteins related to signaling of Hepatocyte Growth Factor receptor.

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Skeletal Muscle Fiber Development

Browse our antibodies, ELISA kits and proteins related to skeletal muscle fiber development.

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Smooth Muscle Cell Migration

Browse our antibodies, ELISA kits and proteins related to smooth muscle cell migration.

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Stem Cell Maintenance

Browse our antibodies, ELISA kits and proteins related to stem cell maintenance.

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Steroid Hormone Biosynthesis

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Steroid Hormone Mediated Signaling Pathway

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Synaptic Membrane

Browse our antibodies, ELISA kits and proteins related to synaptic membranes.

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Synaptic Vesicle Exocytosis

Browse our antibodies, ELISA kits and proteins related to synaptic vesicle exocytosis.

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Synthesis of DNA

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TCR Signaling

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Telomere Maintenance

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Thromboxane A2 Receptor Signaling

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Thyroid Hormone Synthesis

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Toll-Like Receptors Cascades

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Transition Metal Ion Homeostasis

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Tube Formation

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VEGFR1 Specific Signals

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