E2F Transcription Factor 7 (E2F7) (N-Term) Peptide
E2F7
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits E2F7
- E2F7 (E2F Transcription Factor 7 (E2F7))
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- MEVNCLTLKD LISPRQTRLD FAIEDAENAQ KENIFVDRSR MTPKTPMKNE
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-E2F7 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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E2F Transcription Factor 7 (E2F7) peptide
E2F7 Reactivité: Humain, Chien, Porc Hôte: Synthetic BP, Imm
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- E2F7 (E2F Transcription Factor 7 (E2F7))
- Synonymes
- E2F7 Peptide, E2F-7 Peptide, fc43h03 Peptide, si:dkey-217k21.2 Peptide, wu:fc43h03 Peptide, MGC154335 Peptide, A630014C11Rik Peptide, D10Ertd739e Peptide, E2F transcription factor 7 Peptide, E2F transcription factor 7 L homeolog Peptide, E2F7 Peptide, e2f7 Peptide, e2f7.L Peptide, E2f7 Peptide
- Sujet
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E2F7 is a atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. E2F7 mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'- TTTC[CG]CGC-3'. It directly represses transcription of classical E2F transcription factors such as E2F1. It acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. It plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). It is required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter.
Alias Symbols: E2f7,
Protein Size: 904 - Poids moléculaire
- 99 kDa
- ID gène
- 52679
- NCBI Accession
- XP_006513945
- UniProt
- Q6S7F2
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