This is a synthetic peptide designed for use in combination with anti-EPOR antibody (Catalog #: ARP44216_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
The erythropoietin receptor is a member of the cytokine receptor family. Upon erythropoietin binding, the erythropoietin receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis.The erythropoietin receptor is a member of the cytokine receptor family. Upon erythropoietin binding, the erythropoietin receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC138358, EPO-R
Protein Interaction Partner: EPO,EPO,EPOR,GNB2L1,ATXN2L,CBL,CISH,CRKL,CSF2RB,EPO,EPOR,GAB1,GAB2,GNAI1,GNB2L1,GRAP,GRB2,INPP5D,IRS2,JAK2,KIT,KITLG,KLK3,LYN,MAPK1,MAPK3,MST1R,PIK3R1,PLCG1,PLCG2,PTPN11,PTPN6,SH2B2,SHC1,SOCS2,SOCS3,STAT5A,STAT5B,SYK,VAV1,ATXN2L,BTRC,CISH,CRKL,EPO,GNAI1,GNB2L1,GRAP,GRB2,IRS2,JAK2,LYN,PIK3R1,PTPN11,PTPN6,SHC1,SOCS2,SOCS3,STAT5A,SYK,SYP,VAV1