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SUMO1/sentrin Specific Protease 6 (SENP6) (C-Term) Peptide

SENP6 Reactivité: Humain, Souris Hôte: Synthetic BP, WB
N° du produit ABIN983535
  • Antigène Tous les produits SENP6
    SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
    Protein Region
    C-Term
    Origine
    Humain, Souris
    Source
    • 7
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Séquence
    LAVVCFPGLE KPKYEPNPHY HENAVMQKTP SAEDSCVSSA SEMGACSQNS
    Attributs du produit
    This is a synthetic peptide designed for use in combination with anti-Senp6 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Indications d'application
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Antigène
    SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
    Synonymes
    SSP1 Peptide, SUSP1 Peptide, 2810017C20Rik Peptide, E130319N12Rik Peptide, Susp1 Peptide, mKIAA0797 Peptide, fc83h02 Peptide, im:7148342 Peptide, wu:fc83h02 Peptide, zgc:171230 Peptide, SUMO1/sentrin specific peptidase 6 Peptide, SUMO/sentrin specific peptidase 6 Peptide, SUMO1/sentrin specific peptidase 6a Peptide, SENP6 Peptide, Senp6 Peptide, senp6a Peptide
    Sujet
    Senp6 is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Senp6 rocesses preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Senp6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. Senp6 is involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Senp6 desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation and desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

    Alias Symbols: 2810017C20Rik, E130319N12Rik, MGC38009, Susp1, mKIAA0797

    Protein Size: 1132
    Poids moléculaire
    127 kDa
    ID gène
    215351
    NCBI Accession
    NM_146003, NP_666115
    UniProt
    Q6P7W0
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