Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher tous les synonymes
Studies indicate that the high-risk allele of the 10q26 locus encompasses three genes, PLEKHA1, ARMS2 (Montrer ARMS2 Kits ELISA), and HTRA1 (Montrer HTRA1 Kits ELISA) with high linkage disequilibrium.
CX3CR1 (Montrer CX3CR1 Kits ELISA) (T280M and V249I) and PLEKHA1 (A320T) polymorphisms were not found to be associated with age-related macular degeneration in an Indian population.
This study provides evidence of the joint contribution of genetic variants in PLEKHA1/ARMS2 (Montrer ARMS2 Kits ELISA)/HTRA1 (Montrer HTRA1 Kits ELISA) to age-related macular degeneration risk.
TAPP1 binds to protein tyrosine phosphatase PTPL1 (Montrer PTPN13 Kits ELISA).
syntrophins regulate the localization of TAPP1, which may be important for remodeling the actin cytoskeleton in response to growth factor stimulation
PLEKHA1 is strongly implicated as primarily responsible for the evidence of linkage of age-related maculopathy (ARM) to the 10q26 locus and as a major contributor to ARM.susceptibility.
Although a role for PLEKHA1 could not be totally excluded, there was a four times higher age-related macular degeneration risk was associated with haplotype "A-T-A" involving "PLEKHA1-LOC387715-HTRA1 (Montrer HTRA1 Kits ELISA)" risk alleles.
Independent of CFH (Montrer CFH Kits ELISA) genotype or smoking history, an individual's risk of AMD (Montrer AMD1 Kits ELISA) (age-related macular degeneration) could be increased or decreased, depending on their genotype or haplotype in the 10q26 region.
this study shows that TAPP1/2 double knock-out mice develop chronic germinal centers with age and show abnormal expression of B-cell activation (Montrer BLNK Kits ELISA) anddevelop lupus-like characteristics including anti-DNA antibodies and deposition of immune complexes in kidneys
Results identify TAPP1 as an important negative regulator of oligodendrocyte precursor cells differentiation through the Mek (Montrer MDK Kits ELISA)/Erk (Montrer EPHB2 Kits ELISA) signaling pathway.
interacts with phosphatidylinositol (3,4)-bisphosphate thus regulating B-cell activation (Montrer BLNK Kits ELISA) and autoantibody production
This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.
pleckstrin homology domain-containing family A member 1
, pleckstrin homology domain-containing protein family A member 1
, tandem PH domain containing protein-1
, pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
, tandem PH domain-containing protein 1
, PH domain-containing family A member 1