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XSENP1a and XSENP1b are sumo-specific proteases that inhibit normal head formation by inhibiting Wnt (Montrer WNT2 Kits ELISA)/beta-catenin (Montrer CTNNB1 Kits ELISA) signaling.
Molecular dynamics simulations showed that binding of the beta-grasp domain of SUMO1 (Montrer SUMO1 Kits ELISA) induces significant conformational and dynamic changes in SENP1, including widening of the exosite cleft and quenching of nanosecond dynamics in all but a distal region.
GATA1 (Montrer GATA1 Kits ELISA) is an essential downstream target of SENP1 and that the differential expression and response of GATA1 (Montrer GATA1 Kits ELISA) and Bcl-xL (Montrer BCL2L1 Kits ELISA) are a key mechanism underlying chronic mountain sickness pathology.
miRNA1236 regulates hypoxia-induced epithelial-mesenchymal transformation and metastasis by repressing HDAC3 (Montrer HDAC3 Kits ELISA) and SENP1 expression.
SENP1 deSUMOylated SMAD4 (Montrer SMAD4 Kits ELISA) to promote EMT (Montrer ITK Kits ELISA) via up-regulating E-cadherin (Montrer CDH1 Kits ELISA) in prostate cancer cells. Therefore, SENP1 is a potential target for treatment of advanced prostate cancer.
The variability of the SENP1 and SENP2 genes may play a role in breast cancer occurrence.
this study elucidated that SENP1 is essential for triple-negative breast cancer cell proliferation and migration in vitro, as well as tumor formation and metastasis in vivo
Hepatocellular carcinoma cells express a high level of Senp1 which is induced by HGF/c-Met signals. Senp1 silencing reduces the HGF (Montrer HGF Kits ELISA)-induced proliferation and migration of HCC (Montrer FAM126A Kits ELISA) cells, induces HCC (Montrer FAM126A Kits ELISA) cell apoptosis and growth arrest, and epithelial-to-mesenchymal transition, with increase of E-cadherin (Montrer CDH1 Kits ELISA) and ZO-1 (Montrer TJP1 Kits ELISA) expression, decrease of fibronectin (Montrer FN1 Kits ELISA) and N-cadherin (Montrer CDH2 Kits ELISA) expression.
a significant role of SENP1 in the regulation of cell migration and invasion in neuroblastoma (Montrer ARHGEF16 Kits ELISA)
A key role for SENP1 in astrocytoma development and apoptosis.SENP1 inhibition promotes cell apoptosis by regulating NF-kappa B (Montrer NFKB1 Kits ELISA)/Akt (Montrer AKT1 Kits ELISA) signaling pathways.
Genetic interactions of SNPs in CARD14 (Montrer CARD14 Kits ELISA), SENP1 and VEGFA (Montrer VEGFA Kits ELISA) might represent a functional mechanism in the pathogenesis of high altitude polycythemia.
knockdown of SENP1 augments the ability of Shh (Montrer SHH Kits ELISA) to sustain the proliferation of cerebellar granule cell precursors, demonstrating the physiological significance of the negative regulation of Shh (Montrer SHH Kits ELISA) signaling by SENP1.
SUMO1 (Montrer SUMO1 Kits ELISA) conjugation of RB and Lamin A/C (Montrer LMNA Kits ELISA) is modulated by the SUMO protease SENP1 and that sumoylation of both proteins is required for their interaction.
SENP1 plays a neuroprotective role in ischemia/reperfusion injury.
a novel negative feedback loop mediated by STAT3 (Montrer STAT3 Kits ELISA)-SOCS3 (Montrer SOCS3 Kits ELISA), which is tightly controlled by SENP1 via de-SUMOylation of protein tyrosine phosphatase 1B (PTP1B (Montrer PTPN1 Kits ELISA)), in IFN-gamma (Montrer IFNG Kits ELISA) signaling, is reported.
SENP1 deletion in adipocytes causes Type 1 diabetes mellitus via enhanced SUMOylation of NEMO (Montrer IKBKG Kits ELISA), leading to increased NF-kappaB (Montrer NFKB1 Kits ELISA) activity, cytokine production and pancreatic inflammation.
results of the present study are of both theoretical and therapeutic significance to explore the potential roles of SENP1 under IH condition and elucidated the mechanisms underlying microglial survival and activation
A role for islet SENP1 as a regulator of in vivo glucose homeostasis was demonstrated by the tissue-selective and inducible knockout of this enzyme.
SENP1 up-regulation in diseased heart is mediated via calcineurin-NFAT (Montrer NFATC1 Kits ELISA)/MEF2C (Montrer MEF2C Kits ELISA)-PGC-1alpha (Montrer PPARGC1A Kits ELISA) pathway.
SENP1 deficiency exacerbates ischemia-reperfusion injury in cardiomyocytes via a HIF1alpha (Montrer HIF1A Kits ELISA)-dependent pathway.
SENP1 enhances adipogenesis through de-SUMOylation of Sharp-1 (Montrer BHLHE41 Kits ELISA), which then releases Sharp-1 (Montrer BHLHE41 Kits ELISA) repression of PPARgamma (Montrer PPARG Kits ELISA) expression and adipocyte differentiation. These results reveal SENP1 as a novel regulator in adipogenesis.
This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants.
sentrin-specific protease 1
, SUMO1/sentrin specific peptidase 1
, sentrin/SUMO-specific protease 1
, similar to Sentrin-specific protease 1 (Sentrin/SUMO-specific protease SENP1)
, sentrin/SUMO-specific protease SENP1
, sentrin specific protease 1b
, SUMO1/sentrin specific protease 1
, SUMO-1 protease 2
, SUMO-specific protease U1p1
, sentrin specific protease 1a
, Sumo1/sentrin/SMT3 specific peptidase 1