Aperçu des produits pour anti-TAR DNA Binding Protein (TARDBP) Anticorps

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anti-TAR DNA Binding Protein Anticorps (TARDBP)
Chez www.anticorps-enligne.fr sont 241 TAR DNA Binding Protein (TARDBP) Anticorps de 26 de différents fournisseurs disponibles. De plus, nous expédions TAR DNA Binding Protein Kits (32) et TAR DNA Binding Protein Protéines (14) et beaucoup plus de produits pour cette protéine. Un total de 302 TAR DNA Binding Protein produits sont actuellement listés.
Synonymes:
1190002A23Rik, ALS10, C85084, DKFZp459I2127, tardbp, TDP-43, Tdp43, wu:fb77f02, wu:fc52g10
afficher tous les anticorps Gène GeneID UniProt
TARDBP 23435 Q13148
TARDBP 230908 Q921F2
TARDBP 298648  

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anti-TAR DNA Binding Protein Anticorps mieux référencés

  1. Chicken Polyclonal TARDBP Primary Antibody pour ICC, IF - ABIN188986 : Neumann, Sampathu, Kwong, Truax, Micsenyi, Chou, Bruce, Schuck, Grossman, Clark, McCluskey, Miller, Masliah, Mackenzie, Feldman, Feiden, Kretzschmar, Trojanowski, Lee: Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. dans Science (New York, N.Y.) 2006 (PubMed)
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  2. Human Monoclonal TARDBP Primary Antibody pour EIA, IHC (p) - ABIN317572 : Kabashi, Valdmanis, Dion, Spiegelman, McConkey, Vande Velde, Bouchard, Lacomblez, Pochigaeva, Salachas, Pradat, Camu, Meininger, Dupre, Rouleau: TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. dans Nature genetics 2008 (PubMed)
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  3. Cow (Bovine) Polyclonal TARDBP Primary Antibody pour IHC, WB - ABIN2780849 : Buratti, Brindisi, Giombi, Tisminetzky, Ayala, Baralle: TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing. dans The Journal of biological chemistry 2005 (PubMed)
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  4. Cow (Bovine) Polyclonal TARDBP Primary Antibody pour IHC, WB - ABIN2780848 : Estes, Boehringer, Zwick, Tang, Grigsby, Zarnescu: Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS. dans Human molecular genetics 2011 (PubMed)
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  5. Human Polyclonal TARDBP Primary Antibody pour ELISA, WB - ABIN334503 : Zhang, Xu, Dickey, Buratti, Baralle, Bailey, Pickering-Brown, Dickson, Petrucelli: Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 (PubMed)

  6. Human Polyclonal TARDBP Primary Antibody pour IF, WB - ABIN318898 : Ou, Wu, Harrich, García-Martínez, Gaynor: Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. dans Journal of virology 1995 (PubMed)

  7. Human Polyclonal TARDBP Primary Antibody pour IF, IHC (p) - ABIN657685 : Kim, Shanware, Bowler, Tibbetts: Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA. dans The Journal of biological chemistry 2010 (PubMed)

Plus d’anticorps contre TAR DNA Binding Protein partenaires d’interaction

Human TAR DNA Binding Protein (TARDBP) interaction partners

  1. we demonstrated cytoplasmic TDP-43 aggregate formation in neuronal and glial cells following adenoviral transduction of WT and CTF (Montrer NFIA Anticorps) TDP-43 under MG-132 treatment. These TDP-43 aggregates were phosphorylated and ubiquitinated and consisted of electron-dense granules.

  2. emphasize the importance of distinguishing cerebral age-related TDP-43 with sclerosis from late-onset frontotemporal lobar degeneration with TDP-43 pathology and from advanced Alzheimer disease with TDP-43 pathology

  3. Mutant and wild type human TDP-43 replacing the endogenous Drosophila gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects.

  4. The study establishes a functional/physical partnership between FMRP (Montrer FMR1 Anticorps) and TDP-43 that mechanistically links several neurodevelopmental disorders and neurodegenerative diseases.

  5. By silencing TDP-43, authors saw significant inhibition of cell proliferation and metastasis in A375 and WM451 cells. TDP-43 knockdown could suppress glucose transporter type-4 (GLUT4 (Montrer SLC2A4 Anticorps)) expression and reduce glucose uptake.

  6. The present study, based on 15 cases staged for pTDP-43 pathology, reports the finding that pathologically altered TDP-43 in Betz cells reacts differently than that in bulbar or spinal alpha-motoneurons. The major differences between the two types of histological profiles are discussed within the context of their possible consequences and implications for the potential further progression or spread of the pTDP-43 lesions.

  7. This study have shown that TDP-43-positive cytoplasmic inclusions were frequently found in the amygdala of pathologically and genetically confirmed cases of Frontotemporal Lobar Degeneration and Motor Neuron Disease.

  8. Results indicated that a range of disease specific TDP-43 variants are generated in amyotrophic lateral sclerosis patients with different variants being generated in sporadic and familial cases.

  9. heterogeneous structural reorganization and decreased stability of the truncated RRM2 (Montrer RRM2 Anticorps) domain

  10. These results suggest that Perry syndrome may be distinctive type of TDP-43 proteinopathy.

Mouse (Murine) TAR DNA Binding Protein (TARDBP) interaction partners

  1. The findings of this study support a role for nuclear depletion of TDP-43 in the pathogenesis of AD and provide strong rationale for developing novel therapeutics to alleviate the depletion of TDP-43 and functional antemortem biomarkers associated with its nuclear loss.

  2. These results suggested that nuclear localization signal -tagged TDP25 (a carboxyl-terminal fragment of TDP-43) can change its structure to use ordered oligomeric but nontoxic state. Moreover, the structure of ordered oligomers as well as nuclear sequestration may be important in mediating cytotoxicity in ALS pathology.

  3. Mutatgion M337V in TDP-43 impaired the Nrf2 (Montrer NFE2L2 Anticorps)/ARE pathway by reducing the expression of MafK and JDP2 (Montrer JDP2 Anticorps) proteins.

  4. The suppression of TDP-43 mitochondrial localization abolishes WT and mutant TDP-43-induced mitochondrial dysfunction and neuronal loss, and improves phenotypes of transgenic mutant TDP-43 mice.

  5. we found a significant overlap in genes that undergo both RBM17 (Montrer RBM17 Anticorps)- and TDP-43-dependent cryptic splicing repression, many of which are associated with survival. We propose that repression of cryptic splicing by RBPs is critical for neuronal health and survival

  6. These results establish that SMN overexpression in motor neurons slows disease onset and outcome by ameliorating pathological signs in this model of mutant TDP-43-mediated amyotrophic lateral sclerosis (ALS).

  7. These findings suggest that TDP-43 promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43, truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 mislocalization to the cytoplasm.

  8. this study suggests hemizygous TDP-43(M337V) mice as a useful animal model to study TDP-43 toxicity and further consolidates mitochondrial TDP-43 as a novel therapeutic target for TDP-43-linked neurodegenerative diseases.

  9. demonstrated that the levels of HSF1 (Montrer HSF1 Anticorps) and heat shock proteins are significantly reduced in affected neuronal tissues from a TDP-43 transgenic mouse model of amyotrophic lateral sclerosis and patients with sporadic amyotrophic lateral sclerosis.

  10. The present study identified USP7 (Montrer USP7 Anticorps) and TDP-43 as the regulators of CRY1 (Montrer CRY1 Anticorps) and CRY2 (Montrer CRY2 Anticorps), underscoring the significance of the stability control process of CRY (Montrer CRY2 Anticorps) proteins for period determination in the mammalian circadian clockwork.

Zebrafish TAR DNA Binding Protein (TARDBP) interaction partners

  1. Data indicate a method for site-directed single nucleotide editing in two disease-related genes, DNA binding protein (Montrer CNBP Anticorps) tardbp and RNA binding protein fus (Montrer FUS Anticorps).

  2. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.

  3. TARDBP and FUS (Montrer FUS Anticorps) act in a pathogenic pathway that is independent of SOD1 (Montrer SOD1 Anticorps).

TAR DNA Binding Protein (TARDBP) profil antigène

Antigen Summary

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

Alternative names and synonyms associated with TAR DNA Binding Protein (TARDBP)

  • TAR DNA binding protein (TARDBP) anticorps
  • Tardbp protein (tardbp) anticorps
  • TAR DNA binding protein (tardbp) anticorps
  • TAR DNA binding protein (Tardbp) anticorps
  • TAR DNA-binding protein 43-like (LOC100621383) anticorps
  • 1190002A23Rik anticorps
  • ALS10 anticorps
  • C85084 anticorps
  • DKFZp459I2127 anticorps
  • tardbp anticorps
  • TDP-43 anticorps
  • Tdp43 anticorps
  • wu:fb77f02 anticorps
  • wu:fc52g10 anticorps

Protein level used designations for TARDBP

TAR DNA binding protein , TAR DNA-binding protein 43 , Tardbp protein , TDP-43 , TAR DNA-binding protein-43

GENE ID SPECIES
100174676 Pongo abelii
457942 Pan troglodytes
713860 Macaca mulatta
778772 Ciona intestinalis
100051482 Equus caballus
100602228 Nomascus leucogenys
380329 Xenopus laevis
419453 Gallus gallus
23435 Homo sapiens
478234 Canis lupus familiaris
540632 Bos taurus
230908 Mus musculus
298648 Rattus norvegicus
325052 Danio rerio
100718595 Cavia porcellus
101114038 Ovis aries
100621383 Sus scrofa
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