ANAPC5 Protein (AA 2-232, partial) (GST tag)

N° du produit ABIN1046520

Détail du produit

Antigène: ANAPC5 (Anaphase Promoting Complex Subunit 5 (ANAPC5))

Type de proteíne: Recombinant

Attributs du protein: AA 2-232, partial

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette ANAPC5 protéine est marqué à la GST tag.

Application: SDS-PAGE (SDS), ELISA

Séquence: ASVHESLYFN PMMTNGVVHA NVFGIKDWVT PYKIAVLVLL NEMSRTGEGA VSLMERRRLN QLLLPLLQGP DITLSKLYKL IEESCPQLAN SVQIRIKLMA EGELKDMEQF FDDLSDSFSG TEPEVHKTSV VGLFLRHMIL AYSKLSFSQV FKLYTALQQY FQNGEKKTVE DADMELTSRD EGERKMEKEE LDVSVREEEV SCSGPLSQKQ AEFFLSQQAS LLKNDETKAL T

Attributs du produit: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Ref.7

Pureté: 90 %

Information d'application

Commentaires:

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS buffer, 20mM GSH

Stock: -20 °C

Référence

Bechtel, Rosenfelder, Duda, Schmidt, Ernst, Wellenreuther, Mehrle, Schuster, Bahr, Blöcker, Heubner, Hoerlein, Michel, Wedler, Köhrer, Ottenwälder, Poustka, Wiemann, Schupp: "The full-ORF clone resource of the German cDNA Consortium." dans: BMC genomics, Vol. 8, pp. 399, (2008) (PubMed).

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." dans: Genome research, Vol. 14, Issue 10B, pp. 2121-7, (2004) (PubMed).

Beausoleil, Jedrychowski, Schwartz, Elias, Villén, Li, Cohn, Cantley, Gygi: "Large-scale characterization of HeLa cell nuclear phosphoproteins." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, (2004) (PubMed).

Kraft, Herzog, Gieffers, Mechtler, Hagting, Pines, Peters: "Mitotic regulation of the human anaphase-promoting complex by phosphorylation." dans: The EMBO journal, Vol. 22, Issue 24, pp. 6598-609, (2003) (PubMed).

Yu, Peters, King, Page, Hieter, Kirschner: "Identification of a cullin homology region in a subunit of the anaphase-promoting complex." dans: Science (New York, N.Y.), Vol. 279, Issue 5354, pp. 1219-22, (1998) (PubMed).

Détail du antigène

Antigène: ANAPC5 (Anaphase Promoting Complex Subunit 5 (ANAPC5))

Autre désignation: Anaphase-promoting complex subunit 5 (ANAPC5 Produits)

Sujet: Synonyms: APC5,Cyclosome subunit 5

Poids moléculaire: 53.6 kD

UniProt: Q9UJX4

Pathways: M Phase